2024
Mitogen-Activated Protein Kinase Phosphatase-5 is Required for TGF-β Signaling Through a JNK-Dependent Pathway
Dorry S, Perla S, Bennett A. Mitogen-Activated Protein Kinase Phosphatase-5 is Required for TGF-β Signaling Through a JNK-Dependent Pathway. Molecular And Cellular Biology 2024, ahead-of-print: 1-15. PMID: 39607740, DOI: 10.1080/10985549.2024.2426665.Peer-Reviewed Original ResearchMitogen-activated protein kinaseTGF-b signalingMKP-5JNK-dependent pathwayFamily of protein phosphatasesNon-canonical sitesJNK-dependent mannerP38 mitogen-activated protein kinaseMitogen-activated protein kinase phosphatase-5JNK-dependentTranscriptional activityProtein phosphatasesTranscriptome analysisRNA sequencingProtein kinaseJNK inactivationNuclear translocationSignaling activityTGF-bSmad2 phosphorylationPharmacological inhibitionDrivers of fibrosisTissue fibrosisFactor BPathway
2018
Age-Related Expression of Human AT1R Variants and Associated Renal Dysfunction in Transgenic Mice
Jain S, Rana A, Jain K, Perla SK, Puri N, Kumar A. Age-Related Expression of Human AT1R Variants and Associated Renal Dysfunction in Transgenic Mice. American Journal Of Hypertension 2018, 31: 1234-1242. PMID: 30084918, PMCID: PMC6454504, DOI: 10.1093/ajh/hpy121.Peer-Reviewed Original ResearchConceptsTranscriptional regulationHap-IISingle nucleotide polymorphismsBlood pressureVivo ChIP assaysNucleotide polymorphismsTranscription factor USF2Strong transcriptional activityTg miceRenal disordersType I geneAged animalsHaplotype-dependent mannerTransgenic miceTranscriptional environmentI geneChIP assaysTranscriptional activityAssociated renal dysfunctionHigh blood pressurePro-inflammatory markersGenesPhysiological relevanceAge-related expressionAntioxidant defense