2025
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Belabed M, Park M, Blouin C, Balan S, Moon C, Freed G, Quijada-Álamo M, Peros A, Mattiuz R, Reid A, Yatim N, Boumelha J, Azimi C, LaMarche N, Troncoso L, Amabile A, Le Berichel J, Chen S, Wilk C, Brown B, Radford K, Ghosh S, Rothlin C, Yvan-Charvet L, Marron T, Puleston D, Wagenblast E, Bhardwaj N, Lamaze C, Merad M. Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer. Nature Immunology 2025, 26: 188-199. PMID: 39838105, DOI: 10.1038/s41590-024-02065-8.Peer-Reviewed Original ResearchConventional dendritic cellsNiemann-Pick disease type C1Maturation of conventional dendritic cellsExpression of maturation markersCholesterol mobilizationAnti-tumor immunityReceptor tyrosine kinase AXLDendritic cell maturationResponse to cancerTyrosine kinase AXLDendritic cellsImmune receptor signalingMaturation markersAuto-immunityCell maturationReceptor signalingImmunogenic responseTherapeutic targetCholesterol transportLipid nanodomainsSubcellular mechanismsCholesterolType C1CancerCell surface
2024
868 AXL restricts cholesterol mobilization, modulating dendritic cell maturation and the immune response to cancer
Belabed M, Park M, Blouin C, Balan S, Moon C, Boumelha J, Peros A, Mattiuz R, Reid A, Azimi C, LaMarche N, Troncoso L, Berichel J, Wilk M, Brown B, Radford K, Ghosh S, Rothlin C, Yvan-Charvet L, Marron T, Puleston D, Bhardwaj N, Lamaze C, Merad M. 868 AXL restricts cholesterol mobilization, modulating dendritic cell maturation and the immune response to cancer. 2024, a982-a982. DOI: 10.1136/jitc-2024-sitc2024.0868.Peer-Reviewed Original Research
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