2023
Profiling of Differentiation Pattern of Neuro 2A (N2a) Cells upon Exposure to Dopamine, Corticosterone and Monosodium Glutamate
Mathew S, Keerikkattil J. Profiling of Differentiation Pattern of Neuro 2A (N2a) Cells upon Exposure to Dopamine, Corticosterone and Monosodium Glutamate. Physiology 2023, 38: 5727603. DOI: 10.1152/physiol.2023.38.s1.5727603.Peer-Reviewed Original ResearchExposure to dopamineGlial fibrillary acidic proteinTyrosine hydroxylaseNeural crest-derived cell lineMonosodium glutamateDopamine B-hydroxylaseDifferentiation of N2a cellsFibrillary acidic proteinCatecholaminergic pathwaysPathway of differentiationGroup ILineage trackingDopamineN2a cellsImmunocytochemical analysisCorticosteroneControl groupCell linesNeuro-2aDifferential effectsAcidic proteinType differentiation
2022
Lineage Tracking and Differentiation of Neuro 2A cells (N2a) upon exposure to Dopamine, Monosodium Glutamate and Corticosterone
Mathew S, Keerikkattil J. Lineage Tracking and Differentiation of Neuro 2A cells (N2a) upon exposure to Dopamine, Monosodium Glutamate and Corticosterone. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r3706.Peer-Reviewed Original ResearchD1 receptor expressionMonosodium glutamate groupReceptor expressionDA groupCell deathExposure to dopamineMonosodium glutamate treatmentDopamine receptorsControl groupReward systemCorticosterone groupN2a cellsDopamineNeural crest-derived cell lineLate stages of apoptosisMonosodium glutamateCatecholaminergic pathwaysCorticosteroneStages of apoptosisStress hormonesCell to cell communicationDifferentiation of Neuro-2a cellsTreated with DASignal transduction pathwaysPattern of differentiation
2020
Impact of Monosodium Glutamate and Corticosterone in the Hippocampus: Glucocorticoid Regulation and Caspase‐3 mediated Microvascular and Neuronal Apoptosis
Mathew S, Joy K. Impact of Monosodium Glutamate and Corticosterone in the Hippocampus: Glucocorticoid Regulation and Caspase‐3 mediated Microvascular and Neuronal Apoptosis. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.02786.Peer-Reviewed Original ResearchBlood-brain barrierExposure to monosodium glutamateGlucocorticoid receptorApoptotic signaling cascadeEnhanced glucocorticoid receptorDay 8Immediate response to stressEffects of corticosteroneResponse to stressCaspase-3Corticosterone exposureCorticosterone modelBody weightGlutamate modelGroup I control ratsMonosodium glutamate modelDentate gyrusBax-dependent apoptotic pathwayMonosodium glutamateHippocampusNeuronal apoptosisSignaling cascadesGene expressionGroup II ratsMale Wistar rats
2019
Monosodium Glutamate Triggers Neuroendocrine Stress Axis Leading to Apoptosis and Neural Progenitor Cell Activation
Mathew S, Joy K. Monosodium Glutamate Triggers Neuroendocrine Stress Axis Leading to Apoptosis and Neural Progenitor Cell Activation. The FASEB Journal 2019, 33: 554.1-554.1. DOI: 10.1096/fasebj.2019.33.1_supplement.554.1.Peer-Reviewed Original ResearchCRH gene expressionCRH neuronsHypothalamic-pituitary-adrenal (HPA) axisHPA axis sensitivityImmediate response to stressIncreased intrinsic excitabilityPlasma CORT concentrationsDay 8POMC mRNA expressionResponse to stressGlutamate inputsPlasma corticosteroneMonosodium glutamate exposureGlutamate modelMonosodium glutamateNeural stem/progenitor cell markersMale Wistar ratsBody weightMonosodium glutamate modelGroup I control ratsCORT concentrationsNegative feedback mechanismAxis sensitivityGroup II ratsIntrinsic excitability
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply