2021
LOCAL ACTIVATION OF GLUCOCORTICOID SIGNALING IN UTERINE FIBROID CELLS DRIVES GROWTH
Glenn T, Silva E, Suarez P, Flannery C, Whirledge S. LOCAL ACTIVATION OF GLUCOCORTICOID SIGNALING IN UTERINE FIBROID CELLS DRIVES GROWTH. Fertility And Sterility 2021, 116: e419-e420. DOI: 10.1016/j.fertnstert.2021.07.1121.Peer-Reviewed Original ResearchObesity Induces Elevated Oxidative Stress in Uteri of Reproductive Age Mice
Huang J, Xiao E, Tal A, Kelly K, Kim J, Whirledge S, Flannery C. Obesity Induces Elevated Oxidative Stress in Uteri of Reproductive Age Mice. Journal Of The Endocrine Society 2021, 5: a752-a752. DOI: 10.1210/jendso/bvab048.1529.Peer-Reviewed Original ResearchWeeks of dietNC miceHF miceHigher body fatProtein carbonylsOxidative stressAge miceBody fatChronic diet-induced obesityDiet-induced obese miceObesity-related disruptionIndependent risk factorInsulin tolerance testingHigh-fat chowLong-term obesitySeverity of obesityC57BL/6 female miceDiet-induced obesityHigh fat consumptionUterine oxidative stressCYP enzymatic activitiesAge-dependent increaseElevated oxidative stressDNA damageCytochrome P450 expression
2019
SUN-019 The Selective Progesterone Receptor Modulator Ulipristal Acetate Blocks Glucocorticoid Receptor Transactivation
Smalls B, Millard C, Kisanga E, Flannery C, Al-Hendy A, Whirledge S. SUN-019 The Selective Progesterone Receptor Modulator Ulipristal Acetate Blocks Glucocorticoid Receptor Transactivation. Journal Of The Endocrine Society 2019, 3: sun-019. PMCID: PMC6553416, DOI: 10.1210/js.2019-sun-019.Peer-Reviewed Original ResearchSelective progesterone receptor modulatorsAnti-glucocorticoid activityUlipristal acetateGlucocorticoid receptorEffect of UPAHuman uterine fibroid tissueLong-term therapeutic agentGR antagonist RU-486Progesterone receptor modulatorsAntagonist RU 486Post-marketing analysisGlucocorticoid-induced expressionLower glucocorticoid receptorUterine fibroid tissueEndogenous glucocorticoid receptorSynthetic glucocorticoid dexamethasoneCell linesUterine fibroid cellsHuman uterine fibroid cellsFemale reproductive systemUtLM cellsHepatic failureLiver injuryPR expressionTherapeutic options