2023
Leptin-Mediated Induction of IL-6 Expression in Hofbauer Cells Contributes to Preeclampsia Pathogenesis
Ozmen A, Nwabuobi C, Tang Z, Guo X, Larsen K, Guller S, Blas J, Moore M, Kayisli U, Lockwood C, Guzeloglu-Kayisli O. Leptin-Mediated Induction of IL-6 Expression in Hofbauer Cells Contributes to Preeclampsia Pathogenesis. International Journal Of Molecular Sciences 2023, 25: 135. PMID: 38203306, PMCID: PMC10778808, DOI: 10.3390/ijms25010135.Peer-Reviewed Original ResearchConceptsIL-6 expressionHofbauer cellsP65 NF-κBIL-6NF-κBLeptin levelsPreeclampsia pathogenesisElevated serum interleukin-6 levelsSerum interleukin-6 levelsERK1/2 MAPKInterleukin-6 levelsPro-inflammatory phenotypeAnti-inflammatory phenotypeLeptin receptor expressionIL-6 productionPathogenesis of PEPlacental leptin productionPhosphorylation levelsERK1/2 MAPK inhibitorIL-6 regulationConcentration-dependent mannerPE patientsHuman pregnancySecond trimesterLeptin concentrations
2008
Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia
Guller S, Buhimschi CS, Y Y, Huang T, Yang L, Kuczynski E, Zambrano E, Lockwood CJ, Buhimschi IA. Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia. Laboratory Investigation 2008, 88: 1057-1067. PMID: 18679377, PMCID: PMC2682720, DOI: 10.1038/labinvest.2008.74.Peer-Reviewed Original ResearchConceptsPlasminogen activator inhibitor-1Severe preeclampsiaReperfusion injurySFlt-1Soluble fms-like tyrosine kinase-1Fms-like tyrosine kinase-1Ischemia/reperfusion injuryLife-threatening syndromeSubsequent reperfusion injuryTerm control groupPathophysiology of preeclampsiaTyrosine kinase-1Activator inhibitor-1Release of factorsSignificant increasePresence of mRNAUpregulation of mRNACeruloplasmin mRNAPlacental damagePlacental factorsMicroarray gene profilingEndothelium dysfunctionPE placentasQuantitative real-time PCRIntervillous space
1998
Apoptosis and Fas Expression in Human Fetal Membranes1
Runić R, Lockwood C, LaChapelle L, Dipasquale B, Demopoulos R, Kumar A, Guller S. Apoptosis and Fas Expression in Human Fetal Membranes1. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 660-666. PMID: 9467589, DOI: 10.1210/jcem.83.2.4600.Peer-Reviewed Original ResearchConceptsChorionic trophoblastsHuman fetal membranesFetal membranesApoptotic indexWeeks groupCell layerHuman fetal membrane cellsCytoplasmic domain of FasFetal membrane cellsFas messenger ribonucleic acidTrophoblast cell layerDecidual cell typesCondensation of chromatinConsistent with apoptosisSamples of amnionEpithelial cell layerMessenger ribonucleic acidCell surface receptorsWeeks gestationDecidual cellsProstate glandAmnion epitheliumFas signalingAmniotic tissueImmunohistochemical staining
1994
Developmental regulation of glucocorticoid-mediated effects on extracellular matrix protein expression in the human placenta
Guller S, Markiewicz L, Wozniak R, Burnham J, Wang E, Kaplan P, Lockwood C. Developmental regulation of glucocorticoid-mediated effects on extracellular matrix protein expression in the human placenta. Endocrinology 1994, 134: 2064-2071. DOI: 10.1210/en.134.5.2064.Peer-Reviewed Original ResearchEffects of glucocorticoidsTerm cellsLevels of glucocorticoidsTrimester cellsDexamethasone treatmentTrimester of human pregnancyControl levelsGlucocorticoid responseSeparation of placentaTreatment of cytotrophoblastsLevels of hCGControl valuesIncreased glucocorticoid responseHuman first trimesterLow levels of glucocorticoidsGlucocorticoid-mediated effectsLevels of FN mRNARates of FNElevated levels of glucocorticoidsExtracellular matrix protein expressionLevels of FNCytotrophoblast culturesReduced glucocorticoid responsivenessHuman pregnancyFirst-trimester
1993
Glucocorticoid suppression of human placental fibronectin expression: implications in uterine-placental adherence
Guller S, Wozniak R, Krikun G, Burnham J, Kaplan P, Lockwood C. Glucocorticoid suppression of human placental fibronectin expression: implications in uterine-placental adherence. Endocrinology 1993, 133: 1139-1146. DOI: 10.1210/en.133.3.1139.Peer-Reviewed Original ResearchTreatment of cytotrophoblastsIncreased levels of glucocorticoidsEffects of glucocorticoidsHuman term placentaLevels of glucocorticoidsPlacental functionExtracellular matrix protein synthesisHuman parturitionAssociated with parturitionTerm placentaMultiple extracellular matrix proteinsPlacental fibronectinDexamethasone treatmentCytotrophoblastMatrix protein synthesisDexamethasoneGlucocorticoidExtracellular matrix proteinsCell-associated materialImmunoprecipitation studiesOnfFNLevels of total proteinMessenger RNANorthern blottingOncofetal epitope
1992
Growth hormone and fibronectin expression in 3T3 preadipose cells.
Guller S, Allen D, Corin R, Lockwood C, Sonenberg M. Growth hormone and fibronectin expression in 3T3 preadipose cells. Endocrinology 1992, 130: 2609-2616. DOI: 10.1210/en.130.5.2609.Peer-Reviewed Original ResearchInsulin-like growth factor-1Growth factor-1Fibronectin expressionGH actionPreadipose cellsFactor 1Function of GHFibronectin protein expressionLevels of fibronectin mRNASerum-free mediumFibronectin messenger RNAGH treatmentExtracellular matrixFibronectin levelsWestern blot analysisDose-dependentlyDay 1GH effectsGrowth hormoneFibronectin mRNAMRNA expressionProtein expressionGlycerol-3-phosphate dehydrogenase activityImmunoprecipitation studiesControl cells
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