2025
Neuropsychiatric and laboratory outcomes of hepatitis C treatment in an early-treated HIV cohort in Thailand
Ocampo F, Sacdalan C, Pinyakorn S, Paudel M, Wansom T, Poltubtim N, Sriplienchan S, Phanuphak N, Paul R, Hsu D, Colby D, Trautmann L, Spudich S, Chan P. Neuropsychiatric and laboratory outcomes of hepatitis C treatment in an early-treated HIV cohort in Thailand. AIDS Research And Therapy 2025, 22: 20. PMID: 39972347, PMCID: PMC11841302, DOI: 10.1186/s12981-025-00707-x.Peer-Reviewed Original ResearchConceptsWeeks of antiretroviral therapyAcute HIV infectionT-cell countsT cell ratioAntiretroviral therapyPatient Health Questionnaire-9HCV seroconversionDAA treatmentCD4 + and CD8 + T cell countsCD4+ /CD8+ T-cell ratioCD8+ T cell countsDirect-acting antiviral (DAA) therapyAlanine transaminaseCD4+ /CD8+ ratioAspartate transferaseIntravenous drug useEarly HCV infectionSexually transmitted infectionsFollow-up visitPatient Health Questionnaire-9 scoresBackgroundHepatitis C virusHepatitis C treatmentHIV RNAVirological responseDAA therapy
2022
Individual Differences in CD4/CD8 T-Cell Ratio Trajectories and Associated Risk Profiles Modeled From Acute HIV Infection
Paul R, Cho K, Bolzenius J, Sacdalan C, Ndhlovu LC, Trautmann L, Krebs S, Tipsuk S, Crowell TA, Suttichom D, Colby DJ, Premeaux TA, Phanuphak N, Chan P, Kroon E, Vasan S, Hsu D, Carrico A, Valcour V, Ananworanich J, Robb ML, Ake JA, Sriplienchan S, Spudich S, Team F. Individual Differences in CD4/CD8 T-Cell Ratio Trajectories and Associated Risk Profiles Modeled From Acute HIV Infection. Psychosomatic Medicine 2022, 84: 976-983. PMID: 36162059, PMCID: PMC9553252, DOI: 10.1097/psy.0000000000001129.Peer-Reviewed Original ResearchConceptsAcute HIV infectionCD4/CD8 T-cell ratioCD8 T-cell ratioAntiretroviral therapyT-cell countsT-cell recoveryT cell ratioHigh viral loadViral loadHigh CD8Slower CD4HIV infectionLower white blood cell countWeeks of ARTRisk profileWhite blood cell countT-cell trajectoriesMedian viral loadStandard antiretroviral therapyBlood cell countLower eosinophil countsWorse mental healthAHI participantsART onsetFiebig I
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