2020
Minimal detection of cerebrospinal fluid escape after initiation of antiretroviral therapy in acute HIV-1 infection.
Handoko R, Chan P, Jagodzinski L, Pinyakorn S, Ubolyam S, Phanuphak N, Sacdalan C, Kroon E, Dumrongpisutikul N, Paul R, Valcour V, Ananworanich J, Vasan S, Spudich S. Minimal detection of cerebrospinal fluid escape after initiation of antiretroviral therapy in acute HIV-1 infection. AIDS 2020, 35: 777-782. PMID: 33306551, PMCID: PMC7969409, DOI: 10.1097/qad.0000000000002786.Peer-Reviewed Original ResearchConceptsAcute HIV-1 infectionHIV-1 RNACentral nervous systemCSF escapeAntiretroviral therapyHIV-1 infectionWeek 96Week 24HIV-1CSF HIV-1 RNAInitiation of ARTLong-term neurological outcomePlasma HIV-1 RNAWeeks of ARTProspective cohort studyPersistence of HIVHIV-1 persistenceLevels of CSFYears of treatmentHIV-1 replicationNeurological outcomeCohort studyVoluntary counselingChronic infectionEarly treatment
2017
Neurological Complications of HIV Infection
Farhadian S, Patel P, Spudich S. Neurological Complications of HIV Infection. Current Infectious Disease Reports 2017, 19: 50. PMID: 29164407, PMCID: PMC7456329, DOI: 10.1007/s11908-017-0606-5.BooksCombination antiretroviral therapyHIV infectionSuppressive combination antiretroviral therapyChronic HIV infectionPathogenesis of HANDPurpose of ReviewHIVHIV-associated dementiaNeurofilament light chainAntiretroviral therapyCNS infectionNeurological complicationsNeurological outcomeHIV diseaseAsymptomatic individualsMonocyte activityBody of evidenceNeurocognitive disordersPreventive strategiesMultifactorial causesCellular injuryMild formInfectionHIVLight chainRecent studies