2024
Durlobactam in combination with β-lactams to combat Mycobacterium abscessus
Shin E, Dousa K, Taracila M, Bethel C, Nantongo M, Nguyen D, Akusobi C, Kurz S, Plummer M, Daley C, Holland S, Rubin E, Bulitta J, Boom W, Kreiswirth B, Bonomo R. Durlobactam in combination with β-lactams to combat Mycobacterium abscessus. Antimicrobial Agents And Chemotherapy 2024, 69: e01174-24. PMID: 39714147, PMCID: PMC11823594, DOI: 10.1128/aac.01174-24.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsAzabicyclo CompoundsBacterial Proteinsbeta-Lactamase Inhibitorsbeta-Lactamasesbeta-LactamsDrug SynergismImipenemMicrobial Sensitivity TestsMycobacterium abscessusMycobacterium Infections, NontuberculousSynergistic effects of sulopenem in combination with cefuroxime or durlobactam against Mycobacterium abscessus
Dousa K, Shin E, Kurz S, Plummer M, Nantongo M, Bethel C, Taracila M, Nguyen D, Kreiswith B, Daley C, Remy K, Holland S, Bonomo R. Synergistic effects of sulopenem in combination with cefuroxime or durlobactam against Mycobacterium abscessus. MBio 2024, 15: e00609-24. PMID: 38742824, PMCID: PMC11237399, DOI: 10.1128/mbio.00609-24.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial Agentsbeta-Lactamase InhibitorsCefuroximeDrug SynergismHumansMicrobial Sensitivity TestsMolecular Docking SimulationMycobacterium abscessusMycobacterium Infections, NontuberculousProhibitinsConceptsD,D-carboxypeptidaseMinimum inhibitory concentrationB-lactamPenicillin-binding-proteinCell wall synthesisL,D-transpeptidasesResistance to common antibioticsLowest minimum inhibitory concentrationWall synthesisCystic fibrosisD-carboxypeptidaseMass spectrometry analysisB-lactamaseThioester bondRate of treatment failureCell-based assaysMultiple antibioticsB-lactam ringsCommon antibioticsD-transpeptidasesB-lactamase inhibitorsCysteine residuesTime-kill studiesStructural lung diseaseMultidrug-resistant tuberculosis
2021
“One-Two Punch”: Synergistic ß-Lactam Combinations for Mycobacterium abscessus and Target Redundancy in the Inhibition of Peptidoglycan Synthesis Enzymes
Nguyen D, Dousa K, Kurz S, Brown S, Drusano G, Holland S, Kreiswirth B, Boom W, Daley C, Bonomo R. “One-Two Punch”: Synergistic ß-Lactam Combinations for Mycobacterium abscessus and Target Redundancy in the Inhibition of Peptidoglycan Synthesis Enzymes. Clinical Infectious Diseases 2021, 73: 1532-1536. PMID: 34113990, PMCID: PMC8677594, DOI: 10.1093/cid/ciab535.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsDrug SynergismHumansLactamsMicrobial Sensitivity TestsMycobacterium abscessusMycobacterium Infections, NontuberculousPeptidoglycanConceptsPeptidoglycan synthesis enzymesMinimum inhibitory concentration of clinical isolatesB-lactamCombination of imipenemSynthesis enzymesSynergistic in vitroClinical isolatesMinimum inhibitory concentrationMycobacterium abscessusClinical trialsMycobacterial infectionAbscessusEnzymeCeftarolineImipenem
2020
Summary for Clinicians: 2020 Clinical Practice Guideline Summary for the Treatment of Nontuberculous Mycobacterial Pulmonary Disease.
Kurz S, Zha B, Herman D, Holt M, Daley C, Ruminjo J, Thomson C. Summary for Clinicians: 2020 Clinical Practice Guideline Summary for the Treatment of Nontuberculous Mycobacterial Pulmonary Disease. Annals Of The American Thoracic Society 2020, 17: 1033-1039. PMID: 32870060, DOI: 10.1513/annalsats.202003-222cme.Peer-Reviewed Original ResearchMeSH KeywordsHumansLung DiseasesMycobacterium Infections, NontuberculousSocieties, MedicalUnited StatesTime to Expand the Picture of Mycobacterial Lipids: Spotlight on Nontuberculous Mycobacteria
Kurz S, Rivas-Santiago B. Time to Expand the Picture of Mycobacterial Lipids: Spotlight on Nontuberculous Mycobacteria. American Journal Of Respiratory Cell And Molecular Biology 2020, 62: 275-276. PMID: 31580721, PMCID: PMC7055696, DOI: 10.1165/rcmb.2019-0324ed.Peer-Reviewed Original Research
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