2025
P-1503. Dual β-Lactam Approach for Treatment of Mycobacterium abscessus Infections in Adults – Results in 19 Patients
Kalyatanda G, Dousa K, Lyons H, Mardourian M, Rhodes J, Iakovidis A, El-Helou G, Wilson B, Daley C, Holland S, Kreiswirth B, Nguyen D, Shin E, Kurz S, Johnson J, Bonomo R. P-1503. Dual β-Lactam Approach for Treatment of Mycobacterium abscessus Infections in Adults – Results in 19 Patients. Open Forum Infectious Diseases 2025, 12: ofae631.1672. PMCID: PMC11778049, DOI: 10.1093/ofid/ofae631.1672.Peer-Reviewed Original ResearchSubspecies abscessusB-lactamAssociated with high cure ratesIn vitro susceptibility resultsMulti-drug regimensCurrent treatment regimensSolid organ transplantationHigh cure ratesTime to initiationOptimize treatment outcomesMab infectionSynergy testClinical cureImmunocompromised patientsPulmonary infectionDiscontinued treatmentTreatment regimensCase reportClinical outcomesCure rateImmunocompromised individualsAutoimmune diseasesTreatment successEarly treatmentCulture conversion
2013
Can Inhibitor-Resistant Substitutions in the Mycobacterium tuberculosis β-Lactamase BlaC Lead to Clavulanate Resistance?: a Biochemical Rationale for the Use of β-Lactam–β-Lactamase Inhibitor Combinations
Kurz S, Wolff K, Hazra S, Bethel C, Hujer A, Smith K, Xu Y, Tremblay L, Blanchard J, Nguyen L, Bonomo R. Can Inhibitor-Resistant Substitutions in the Mycobacterium tuberculosis β-Lactamase BlaC Lead to Clavulanate Resistance?: a Biochemical Rationale for the Use of β-Lactam–β-Lactamase Inhibitor Combinations. Antimicrobial Agents And Chemotherapy 2013, 57: 6085-6096. PMID: 24060876, PMCID: PMC3837893, DOI: 10.1128/aac.01253-13.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAntitubercular Agentsbeta-Lactamase Inhibitorsbeta-LactamasesClavulanic AcidDrug Therapy, CombinationEscherichia coliExtensively Drug-Resistant TuberculosisGene ExpressionHumansMeropenemMicrobial Sensitivity TestsMutagenesis, Site-DirectedMycobacterium tuberculosisProtein EngineeringRecombinant ProteinsThienamycinsConceptsInhibitor combinationsResistance to clavulanic acidMultidrug resistanceDrug resistanceClavulanic acidExtensively drug-resistant M. tuberculosis strainsEmergence of multidrug resistanceCombination of meropenemDrug-resistant M. tuberculosis strainsPresence of ampicillinAmino acid residuesExtensively drug-resistantM. tuberculosis strainsNovel treatment strategiesInhibition of growthPotential therapeutic targetTreatment regimensTherapeutic modalitiesTreatment strategiesInhibitor resistanceM. tuberculosisEnzymatic assayImpaired inhibitionTherapeutic targetAcid resistance
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