2023
Fishing for “complements” with vascular organoid models of microvascular disease
Gu S, Yarovinsky T, Hwa J. Fishing for “complements” with vascular organoid models of microvascular disease. Cell Stem Cell 2023, 30: 1285-1286. PMID: 37802032, DOI: 10.1016/j.stem.2023.09.004.Commentaries, Editorials and LettersHelicobacter pylori–negative mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach: A clinicopathologic analysis
Gu S, Siddon A, Huntington S, Jain D. Helicobacter pylori–negative mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach: A clinicopathologic analysis. American Journal Of Clinical Pathology 2023, 160: 612-619. PMID: 37556379, PMCID: PMC10691190, DOI: 10.1093/ajcp/aqad088.Peer-Reviewed Original ResearchConceptsHP-positive patientsLymphoid tissue lymphomaChronic gastritisMALT lymphomaHP-negative casesTissue lymphomaHelicobacter pylori-negative mucosaPrimary gastric MALT lymphomaB-cell gene rearrangementsAvailable pathology reportsHP-negative patientsGastric MALT lymphomaHP-negative groupHelicobacter pylori infectionReview of slidesMALT lymphoma casesAdditional laboratory testingHP eradicationDisease recurrenceOptimal management strategyClinicopathologic analysisClinicopathologic featuresHistologic gastritisHP-positive casesInitial diagnosisSOD2 in platelets: with age comes responsibility
Jain K, Gu S, Hwa J. SOD2 in platelets: with age comes responsibility. Journal Of Thrombosis And Haemostasis 2023, 21: 1077-1081. PMID: 36716965, DOI: 10.1016/j.jtha.2023.01.016.Commentaries, Editorials and Letters
2020
Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation
Gu SX, Tyagi T, Jain K, Gu VW, Lee SH, Hwa JM, Kwan JM, Krause DS, Lee AI, Halene S, Martin KA, Chun HJ, Hwa J. Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation. Nature Reviews Cardiology 2020, 18: 194-209. PMID: 33214651, PMCID: PMC7675396, DOI: 10.1038/s41569-020-00469-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdministration, InhalationAnticoagulantsBlood Coagulation DisordersBlood Platelet DisordersCOVID-19COVID-19 Drug TreatmentEndothelium-Dependent Relaxing FactorsEndothelium, VascularEpoprostenolHeart Disease Risk FactorsHumansIloprostInflammationNitric OxidePlatelet Aggregation InhibitorsSARS-CoV-2Systemic Inflammatory Response SyndromeThrombosisThrombotic MicroangiopathiesVascular DiseasesVasodilator AgentsVenous ThromboembolismConceptsCardiovascular risk factorsRisk factorsCOVID-19Severe acute respiratory syndrome coronavirus 2Pre-existing cardiovascular diseaseAcute respiratory syndrome coronavirus 2Traditional cardiovascular risk factorsAcute respiratory distress syndromeRespiratory syndrome coronavirus 2Respiratory distress syndromeManagement of patientsSyndrome coronavirus 2COVID-19 pathologyCoronavirus disease 2019Potential therapeutic strategyCytokine stormEndothelial dysfunctionThrombotic complicationsDistress syndromeExcessive inflammationCoronavirus 2Severe outcomesAdvanced ageCardiovascular diseaseDisease 2019
2018
Targeting platelet EPCR for better therapeutic factor VIIa activity
Gu S, Lentz S. Targeting platelet EPCR for better therapeutic factor VIIa activity. Journal Of Thrombosis And Haemostasis 2018, 16: 1814-1816. PMID: 29982998, PMCID: PMC6156984, DOI: 10.1111/jth.14231.Peer-Reviewed Original ResearchFibrin films: overlooked hemostatic barriers against microbial infiltration
Gu S, Lentz S. Fibrin films: overlooked hemostatic barriers against microbial infiltration. Journal Of Clinical Investigation 2018, 128: 3243-3245. PMID: 29939163, PMCID: PMC6063499, DOI: 10.1172/jci121858.Peer-Reviewed Original ResearchConceptsFiber network
2015
Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling
Klutho P, Pennington S, Scott J, Wilson K, Gu S, Doddapattar P, Xie L, Venema A, Zhu L, Chauhan A, Lentz S, Grumbach I. Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling. Arteriosclerosis Thrombosis And Vascular Biology 2015, 35: 2594-2604. PMID: 26449752, PMCID: PMC4662651, DOI: 10.1161/atvbaha.115.305857.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAortic DiseasesApolipoproteins EAtherosclerosisCarotid ArteriesCarotid Artery InjuriesCell CycleCell Cycle ProteinsCell MovementCell ProliferationCells, CulturedDisease Models, AnimalFemaleGene DeletionHumansHyperplasiaMaleMethionine Sulfoxide ReductasesMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Myocytes, Smooth MuscleNeointimaraf Kinasesras ProteinsSignal TransductionThrombosisTime FactorsConceptsVascular smooth muscle cellsSmooth muscle cellsMuscle cellsVascular injuryAortic vascular smooth muscle cellsExtracellular signal-regulated kinase 1/2 signalingVascular smooth muscle cell proliferationNeointimal hyperplasiaSignaling pathwayApolipoprotein E-deficient miceRegulation of vascular smooth muscle cell proliferationSmooth muscle cell proliferationActivation of extracellular signal-regulated kinase 1/2Methionine sulfoxide reductase ACell proliferationExtracellular signal-regulated kinase 1/2Signal-regulated kinase 1/2Muscle cell proliferationAtherosclerotic lesion areaRetinoblastoma protein phosphorylationCyclin D1 proteinModels of vascular diseaseControl micePhotochemical injuryNeointimal areaDeficiency of Superoxide Dismutase Impairs Protein C Activation and Enhances Susceptibility to Experimental Thrombosis
Dayal S, Gu S, Hutchins R, Wilson K, Wang Y, Fu X, Lentz S. Deficiency of Superoxide Dismutase Impairs Protein C Activation and Enhances Susceptibility to Experimental Thrombosis. Arteriosclerosis Thrombosis And Vascular Biology 2015, 35: 1798-1804. PMID: 26069236, PMCID: PMC4514539, DOI: 10.1161/atvbaha.115.305963.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarotid Artery InjuriesCarotid Artery, CommonCatalaseDisease Models, AnimalEnzyme ActivationHumansMice, 129 StrainMice, TransgenicOxidation-ReductionOxidative StressProtein CSuperoxide DismutaseSuperoxide Dismutase-1SuperoxidesThrombomodulinThrombosisVena Cava, InferiorVenous ThrombosisConceptsSod1(-/-) miceSuperoxide dismutase-1Activation of protein CProtein C activationProtein CInferior vena cava ligationLevels of protein CEndothelial protein C receptorVena cava ligationC activityImpaired protein C activationReactive oxygen speciesGeneration of activated protein CProtein C receptorExpression of thrombomodulinCarotid artery thrombosisThrombosis in vivoIn vitro studiesSod1(-/-Thrombin in vivoLevels of reactive oxygen speciesElevated levels of reactive oxygen speciesVenous thrombosisProthrombotic effectsMurine modelRegulation of thrombosis and vascular function by protein methionine oxidation
Gu S, Stevens J, Lentz S. Regulation of thrombosis and vascular function by protein methionine oxidation. Blood 2015, 125: 3851-3859. PMID: 25900980, PMCID: PMC4473114, DOI: 10.1182/blood-2015-01-544676.Peer-Reviewed Original ResearchConceptsProtein methionine oxidationMethionine residuesRedox regulation of protein functionRegulation of protein functionOxidation-sensitive methionine residuesMethionine oxidationMethionine sulfoxide reductaseIntracellular redox stateRegulatory domainProtein functionSulfoxide reductaseCellular homeostasisRedox regulationStereospecific enzymesReactive oxygen speciesRegulation of thrombosisSignaling moleculesGene expressionRedox biologyRedox sensorCell adhesionRedox balanceMethionine sulfoxideProteinInflammatory gene expression
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