2020
Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation
Gu SX, Tyagi T, Jain K, Gu VW, Lee SH, Hwa JM, Kwan JM, Krause DS, Lee AI, Halene S, Martin KA, Chun HJ, Hwa J. Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation. Nature Reviews Cardiology 2020, 18: 194-209. PMID: 33214651, PMCID: PMC7675396, DOI: 10.1038/s41569-020-00469-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdministration, InhalationAnticoagulantsBlood Coagulation DisordersBlood Platelet DisordersCOVID-19COVID-19 Drug TreatmentEndothelium-Dependent Relaxing FactorsEndothelium, VascularEpoprostenolHeart Disease Risk FactorsHumansIloprostInflammationNitric OxidePlatelet Aggregation InhibitorsSARS-CoV-2Systemic Inflammatory Response SyndromeThrombosisThrombotic MicroangiopathiesVascular DiseasesVasodilator AgentsVenous ThromboembolismConceptsCardiovascular risk factorsRisk factorsCOVID-19Severe acute respiratory syndrome coronavirus 2Pre-existing cardiovascular diseaseAcute respiratory syndrome coronavirus 2Traditional cardiovascular risk factorsAcute respiratory distress syndromeRespiratory syndrome coronavirus 2Respiratory distress syndromeManagement of patientsSyndrome coronavirus 2COVID-19 pathologyCoronavirus disease 2019Potential therapeutic strategyCytokine stormEndothelial dysfunctionThrombotic complicationsDistress syndromeExcessive inflammationCoronavirus 2Severe outcomesAdvanced ageCardiovascular diseaseDisease 2019
2015
Regulation of thrombosis and vascular function by protein methionine oxidation
Gu S, Stevens J, Lentz S. Regulation of thrombosis and vascular function by protein methionine oxidation. Blood 2015, 125: 3851-3859. PMID: 25900980, PMCID: PMC4473114, DOI: 10.1182/blood-2015-01-544676.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHumansMethionineOxidation-ReductionOxidative StressProteinsReactive Oxygen SpeciesThrombosisVascular DiseasesConceptsProtein methionine oxidationMethionine residuesRedox regulation of protein functionRegulation of protein functionOxidation-sensitive methionine residuesMethionine oxidationMethionine sulfoxide reductaseIntracellular redox stateRegulatory domainProtein functionSulfoxide reductaseCellular homeostasisRedox regulationStereospecific enzymesReactive oxygen speciesRegulation of thrombosisSignaling moleculesGene expressionRedox biologyRedox sensorCell adhesionRedox balanceMethionine sulfoxideProteinInflammatory gene expression
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