2022
A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences
Tyagi T, Jain K, Gu S, Qiu M, Gu V, Melchinger H, Rinder H, Martin K, Gardiner E, Lee A, Tang W, Hwa J. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nature Cardiovascular Research 2022, 1: 223-237. PMID: 37502132, PMCID: PMC10373053, DOI: 10.1038/s44161-022-00021-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsVascular smooth muscle cellsPlatelet functional assaysCoronavirus disease 2019Smooth muscle cellsImmune cellsImmune regulationVascular remodelingDisease 2019Pathophysiological processesTranslational relevancePatient diagnosisFlow cytometryMuscle cellsPlatelet biologyFunctional assaysPlatelet investigationsHomeostatic processesPlateletsPhenotypic heterogeneityFunctional stateClinical scienceCellsAdditional roleThrombosisSuch diverse functions
2015
Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling
Klutho P, Pennington S, Scott J, Wilson K, Gu S, Doddapattar P, Xie L, Venema A, Zhu L, Chauhan A, Lentz S, Grumbach I. Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling. Arteriosclerosis Thrombosis And Vascular Biology 2015, 35: 2594-2604. PMID: 26449752, PMCID: PMC4662651, DOI: 10.1161/atvbaha.115.305857.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAortic DiseasesApolipoproteins EAtherosclerosisCarotid ArteriesCarotid Artery InjuriesCell CycleCell Cycle ProteinsCell MovementCell ProliferationCells, CulturedDisease Models, AnimalFemaleGene DeletionHumansHyperplasiaMaleMethionine Sulfoxide ReductasesMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Myocytes, Smooth MuscleNeointimaraf Kinasesras ProteinsSignal TransductionThrombosisTime FactorsConceptsVascular smooth muscle cellsSmooth muscle cellsMuscle cellsVascular injuryAortic vascular smooth muscle cellsExtracellular signal-regulated kinase 1/2 signalingVascular smooth muscle cell proliferationNeointimal hyperplasiaSignaling pathwayApolipoprotein E-deficient miceRegulation of vascular smooth muscle cell proliferationSmooth muscle cell proliferationActivation of extracellular signal-regulated kinase 1/2Methionine sulfoxide reductase ACell proliferationExtracellular signal-regulated kinase 1/2Signal-regulated kinase 1/2Muscle cell proliferationAtherosclerotic lesion areaRetinoblastoma protein phosphorylationCyclin D1 proteinModels of vascular diseaseControl micePhotochemical injuryNeointimal area
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