2024
Demographic diversity in platelet function and response to antiplatelet therapy
Jain K, Tyagi T, Gu S, Faustino E, Hwa J. Demographic diversity in platelet function and response to antiplatelet therapy. Trends In Pharmacological Sciences 2024, 46: 78-93. PMID: 39672782, PMCID: PMC11710996, DOI: 10.1016/j.tips.2024.11.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsResponse to antiplatelet therapyCardiovascular diseaseAntiplatelet therapyPlatelet biologyPathological platelet activationCardiovascular disease riskNon-genetic factorsPopulation-based differencesAntiplatelet strategiesPlatelet functionCardiovascular outcomesDiverse rolesPlatelet activationTherapeutic approachesTherapyPlateletBiologyHigh-Dimensional Single-Cell Mass Cytometry Demonstrates Differential Platelet Functional Phenotypes in Infants With Congenital Heart Disease
Gu S, Marcus B, Gu V, Varghese A, Hwa J, Faustino E. High-Dimensional Single-Cell Mass Cytometry Demonstrates Differential Platelet Functional Phenotypes in Infants With Congenital Heart Disease. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: 2530-2539. PMID: 39171400, PMCID: PMC11602369, DOI: 10.1161/atvbaha.124.321131.Peer-Reviewed Original ResearchCongenital heart diseaseNon-CHD controlsSubpopulation of plateletsCytokine analysisAssociated with congenital heart diseaseSurface markersPlatelet activationHeart diseaseAssociated with hematological abnormalitiesChildren's Heart CenterPlasma cytokine analysisComplex heart defectsBlood of infantsThrombotic vascular complicationsIL (interleukin)-6Cell surface markersDecreased platelet activationMass cytometry approachPlatelet surface markersHypogranular plateletsHeart defectsBleeding eventsPlasma cytokinesPlatelet function phenotypesInflammatory markers
2022
Redox Mechanisms of Platelet Activation in Aging
Gu S, Dayal S. Redox Mechanisms of Platelet Activation in Aging. Antioxidants 2022, 11: 995. PMID: 35624860, PMCID: PMC9137594, DOI: 10.3390/antiox11050995.Peer-Reviewed Original ResearchVascular diseasePrevalence of cardiovascular diseaseTargeted therapeutic strategiesMechanisms of platelet activationOxidative stressThrombotic vascular diseaseImpact of comorbid conditionsRedox dysregulationVascular systemDisease progressionTherapeutic strategiesPlatelet activationVascular disease pathogenesisRisk factorsComorbid conditionsHigher incidenceCardiovascular diseaseDisease pathogenesisAge-related vascular diseasesVascular cellsReactive oxygen speciesVascular physiologyDiseasePhysiological declineAge
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply