2025
Enhancing nucleic acid delivery by the integration of artificial intelligence into lipid nanoparticle formulation
Amoako K, Mokhammad A, Malik A, Yesudasan S, Wheba A, Olagunju O, Gu S, Yarovinsky T, Faustino E, Nguyen J, Hwa J. Enhancing nucleic acid delivery by the integration of artificial intelligence into lipid nanoparticle formulation. Frontiers In Medical Technology 2025, 7: 1591119. PMID: 40589473, PMCID: PMC12206802, DOI: 10.3389/fmedt.2025.1591119.Peer-Reviewed Original ResearchNucleic acid deliveryLipid nanoparticlesAcid deliveryDesign of lipid nanoparticlesMessenger RNADeliver messenger RNAEnhancing nucleic acid deliveryLipid nanoparticle formulationImmune response modulationHematologic therapyPlatelet-related disordersNucleic acid cargoHematological treatmentNanoparticle formulationGold standardEndosomal trappingTherapeutic potentialPersonalized medicineDelivery efficiencyNanoparticle designPlateletCellular targetsResponse modulationDeliveryTransfection barriers
2024
Demographic diversity in platelet function and response to antiplatelet therapy
Jain K, Tyagi T, Gu S, Faustino E, Hwa J. Demographic diversity in platelet function and response to antiplatelet therapy. Trends In Pharmacological Sciences 2024, 46: 78-93. PMID: 39672782, PMCID: PMC11710996, DOI: 10.1016/j.tips.2024.11.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsResponse to antiplatelet therapyCardiovascular diseaseAntiplatelet therapyPlatelet biologyPathological platelet activationCardiovascular disease riskNon-genetic factorsPopulation-based differencesAntiplatelet strategiesPlatelet functionCardiovascular outcomesDiverse rolesPlatelet activationTherapeutic approachesTherapyPlateletBiology
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