2024
Rare genetic variation in fibronectin 1 (FN1) protects against APOE ɛ4 in Alzheimer’s Disease
Bhattarai P, Gunasekaran T, Uzrek B, Reyes‐Dumeyer D, Jülich D, Lee A, Yilmaz E, Tayran H, Lantigua R, Medrano M, Mejia D, Recio P, Flaherty D, Dalgard C, Nuriel T, Ertekin‐Taner N, Dickson D, Teich A, Holley S, Mayeux R, Kizil C, Vardarajan B. Rare genetic variation in fibronectin 1 (FN1) protects against APOE ɛ4 in Alzheimer’s Disease. Alzheimer's & Dementia 2024, 20: e089111. PMCID: PMC11710415, DOI: 10.1002/alz.089111.Peer-Reviewed Original ResearchWhole-genome sequencingLoss-of-functionIn vivo functional studiesFibronectin 1Genetic variationAlzheimer's diseaseFunctional studiesWhole-genome sequence analysisTarget genesRare genetic variationLoss-of-function mutationsPotential gene variantsZebrafish modelGenome sequenceProtective variantsAPOE variantsGenetic variantsECM proteinsZebrafish AD modelBioinformatics analysisAD pathologyPotential therapeutic interventional targetsPathway analysisPostmortem human brain tissueRare variants
2012
Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud
Stulberg MJ, Lin A, Zhao H, Holley SA. Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud. Developmental Biology 2012, 369: 298-307. PMID: 22796649, PMCID: PMC3423502, DOI: 10.1016/j.ydbio.2012.07.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceDNA PrimersFibroblast Growth FactorsGene Expression Regulation, DevelopmentalGene Regulatory NetworksGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaMAP Kinase Signaling SystemModels, BiologicalPhosphatidylinositol 3-KinasesPhosphorylationProto-Oncogene Proteins c-aktSignal TransductionTailWnt Signaling PathwayZebrafishZebrafish ProteinsConceptsZebrafish tailbudCell fate specificationCell fate changesCo-regulated genesWnt antagonist Dkk1Reciprocal positive regulationFate specificationFate changesNascent transcriptionAxis elongationProtein phosphorylationPhosphorylation of GSK3βPI3-kinaseFGF pathwayMesodermal developmentTail elongationPositive regulationTarget genesAntagonist DKK1TailbudFibroblast growth factorWntPhosphorylation levelsTranscriptionGSK3β phosphorylation
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