2016
A Sawtooth Pattern of Cadherin 2 Stability Mechanically Regulates Somite Morphogenesis
McMillen P, Chatti V, Jülich D, Holley SA. A Sawtooth Pattern of Cadherin 2 Stability Mechanically Regulates Somite Morphogenesis. Current Biology 2016, 26: 542-549. PMID: 26853361, PMCID: PMC4822709, DOI: 10.1016/j.cub.2015.12.055.Peer-Reviewed Original ResearchConceptsECM assemblyGenetic mosaicsPosterior somitesDifferential cadherin expressionExtracellular matrixCell-ECM adhesionFN matrix assemblyBoundary formationVertebrate gastrulationSomite boundariesSomite morphogenesisCytoskeletal contractilityParaxial mesodermEmbryonic precursorsCDH activityMatrix assemblyCadherin expressionCDH2SomitesTissue boundariesIntegrin α5SomitogenesisCell sortingCell aggregatesAssembly
2015
Cross-Scale Integrin Regulation Organizes ECM and Tissue Topology
Jülich D, Cobb G, Melo AM, McMillen P, Lawton AK, Mochrie SG, Rhoades E, Holley SA. Cross-Scale Integrin Regulation Organizes ECM and Tissue Topology. Developmental Cell 2015, 34: 33-44. PMID: 26096733, PMCID: PMC4496283, DOI: 10.1016/j.devcel.2015.05.005.Peer-Reviewed Original ResearchConceptsExtracellular matrixCadherin-2Integrin α5Cell-cell adhesionFluorescence cross-correlation spectroscopyECM protein fibronectinSomite boundariesCross-correlation spectroscopyAdjacent cell membranesBody elongationECM assemblyIntegrin associationIntegrin activationPhysical associationActive conformationFibronectin fibrillogenesisProtein fibronectinTissue assemblyIntegrin conformationTissue topologyInactive integrinsCell membraneCross-scale mechanismsStereotypic patternAnimal tissues
1998
Zebrafish segmentation and pair‐rule patterning
van Eeden F, Holley S, Haffter P, Nüsslein‐Volhard C. Zebrafish segmentation and pair‐rule patterning. Genesis 1998, 23: 65-76. PMID: 9706695, DOI: 10.1002/(sici)1520-6408(1998)23:1<65::aid-dvg7>3.0.co;2-4.Peer-Reviewed Original ResearchConceptsDrosophila segment polarity geneSegment polarity genesPair-rule patterningParaxial mesodermZebrafish homologueSomite boundariesPolarity genesPair-rule gene hairyPair-rule genesPair-rule phenotypeWild-type embryosGroup of genesGroup of mutantsGenetic screenVertebrate embryosDouble mutantSomite formationZebrafish segmentationHairy phenotypeMutantsMesodermSonic hedgehogGenesHomologuesHER1 expression
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