Rare genetic variation in fibronectin 1 (FN1) protects against APOE ɛ4 in Alzheimer’s Disease
Bhattarai P, Gunasekaran T, Uzrek B, Reyes‐Dumeyer D, Jülich D, Lee A, Yilmaz E, Tayran H, Lantigua R, Medrano M, Mejia D, Recio P, Flaherty D, Dalgard C, Nuriel T, Ertekin‐Taner N, Dickson D, Teich A, Holley S, Mayeux R, Kizil C, Vardarajan B. Rare genetic variation in fibronectin 1 (FN1) protects against APOE ɛ4 in Alzheimer’s Disease. Alzheimer's & Dementia 2024, 20: e089111. PMCID: PMC11710415, DOI: 10.1002/alz.089111.Peer-Reviewed Original ResearchWhole-genome sequencingLoss-of-functionIn vivo functional studiesFibronectin 1Genetic variationAlzheimer's diseaseFunctional studiesWhole-genome sequence analysisTarget genesRare genetic variationLoss-of-function mutationsPotential gene variantsZebrafish modelGenome sequenceProtective variantsAPOE variantsGenetic variantsECM proteinsZebrafish AD modelBioinformatics analysisAD pathologyPotential therapeutic interventional targetsPathway analysisPostmortem human brain tissueRare variants
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply