2023
Injury prevents Ras mutant cell expansion in mosaic skin
Gallini S, Annusver K, Rahman N, Gonzalez D, Yun S, Matte-Martone C, Xin T, Lathrop E, Suozzi K, Kasper M, Greco V. Injury prevents Ras mutant cell expansion in mosaic skin. Nature 2023, 619: 167-175. PMID: 37344586, PMCID: PMC10322723, DOI: 10.1038/s41586-023-06198-y.Peer-Reviewed Original ResearchConceptsWild-type cellsRas family proteinsCell cycle inhibitor p21Family proteinsOncogenic RasGenetic approachesMosaic tissuesInhibition of EGFRInhibitor p21EGFR ligandsEGFR pathwayCell expansionAberrant growthConstitutive lossDifferential activationParacrine secretionAbsence of injuryCellsCompetitive balanceInjury repairHealthy skinInjurySkinProteinPathway
2022
Double knockin mice show NF-ÎşB trajectories in immune signaling and aging
Rahman S, Aqdas M, Martin E, Ardori F, Songkiatisak P, Oh K, Uderhardt S, Yun S, Claybourne Q, McDevitt R, Greco V, Germain R, Tessarollo L, Sung M. Double knockin mice show NF-ÎşB trajectories in immune signaling and aging. Cell Reports 2022, 41: 111682. PMID: 36417863, PMCID: PMC9764224, DOI: 10.1016/j.celrep.2022.111682.Peer-Reviewed Original Research
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