2024
Finding Your CAR The Road Ahead for Engineered T Cells
Chen P, Raghunandan R, Morrow J, Katz S. Finding Your CAR The Road Ahead for Engineered T Cells. American Journal Of Pathology 2024, 194: 1409-1423. PMID: 38697513, PMCID: PMC11284763, DOI: 10.1016/j.ajpath.2024.04.002.Peer-Reviewed Original ResearchConceptsChimeric antigen receptorCAR-T cellsAdoptive cellular therapyEngineered T cellsT cellsCellular therapyTumor cellsInfusion of CAR T cellsChimeric antigen receptor T cellsCAR-T cell cytotoxicityCAR-T cell persistenceCAR-T cell therapyT cell persistenceT-cell therapyT cell cytotoxicityTarget tumor antigensCytokine release syndromePathology laboratoryEvaluate side effectsTarget specific antigensTarget antigen identificationTransformative immunotherapyTumor antigensAntigen lossTumor microenvironment
2019
A versatile flow-based assay for immunocyte-mediated cytotoxicity
Rabinovich PM, Zhang J, Kerr SR, Cheng BH, Komarovskaya M, Bersenev A, Hurwitz ME, Krause DS, Weissman SM, Katz SG. A versatile flow-based assay for immunocyte-mediated cytotoxicity. Journal Of Immunological Methods 2019, 474: 112668. PMID: 31525367, PMCID: PMC6891822, DOI: 10.1016/j.jim.2019.112668.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorCell NucleusCytotoxicity Tests, ImmunologicCytotoxicity, ImmunologicFlow CytometryHigh-Throughput Screening AssaysHumansImmunotherapy, AdoptiveKiller Cells, NaturalLymphocytes, Tumor-InfiltratingMaleMelanomaMice, Inbred C57BLPredictive Value of TestsReceptors, Chimeric AntigenReproducibility of ResultsSkin NeoplasmsT-LymphocytesTime FactorsWorkflowConceptsCell-mediated cytotoxicityTumor-Infiltrating LymphocytesEffector cellsTarget cellsNK-92 cellsChimeric antigen receptorNuclear staining patternInfiltrating lymphocytesT cellsEffector nucleiFlow-based assayImmune systemFlow cytometryStaining patternAntigen receptorDead cellsKilling reactionCytotoxicityCell permeable dyeCellsAssaysCell mixturesNuclear proteinsNovel strategyCell proteins
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