2024
Mechanosensing regulates tissue repair program in macrophages
Meizlish M, Kimura Y, Pope S, Matta R, Kim C, Philip N, Meyaard L, Gonzalez A, Medzhitov R. Mechanosensing regulates tissue repair program in macrophages. Science Advances 2024, 10: eadk6906. PMID: 38478620, PMCID: PMC10936955, DOI: 10.1126/sciadv.adk6906.Peer-Reviewed Original ResearchConceptsExtracellular matrixRegulate chromatin accessibilityTissue repair programGene expression programsCytoskeletal dynamicsChromatin accessibilityAmoeboid migrationCytoskeletal remodelingBiochemical signalsTissue homeostasisExpression programsColony-stimulating factor-1Tissue-resident macrophagesFactor 1MechanosensingRegulating tissue repairTissue integrityMacrophagesTissueThree-dimensional environmentRepair programHomeostasis
2021
Microenvironment controls inflammatory response in macrophages
Zhou X, Pope S, Medzhitov R. Microenvironment controls inflammatory response in macrophages. The Journal Of Immunology 2021, 206: 111.03-111.03. DOI: 10.4049/jimmunol.206.supp.111.03.Peer-Reviewed Original ResearchInflammatory gene expressionInflammatory responseInflammatory response to lipopolysaccharideGene expressionModulate immune functionResponse to lipopolysaccharideControlling inflammatory gene expressionControlling inflammatory responsesTissue environmentPH-sensing receptorImmune cellsInflammatory conditionsInflammatory programGene-specific mannerTissue dysfunctionImmune functionNF-kBTissue microenvironmentPathway activationNarrow homeostatic rangeChromatin landscapeGene classesTissue homeostasisTranscriptional circuitsChromatin remodeling
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