2024
Macrophages restrain pathological interferon responses during viral respiratory infection
Rodriguez-Morales P, Hoagland D, Mann A, Yu S, Lai A, Baez Vazquez A, Medzhitov R, Franklin R. Macrophages restrain pathological interferon responses during viral respiratory infection. The Journal Of Immunology 2024, 212: 0536_5144-0536_5144. DOI: 10.4049/jimmunol.212.supp.0536.5144.Peer-Reviewed Original ResearchIFN-I productionOncostatin MBlockade of IFN-I signalingViral stimuliEpithelial cellsIFN-IOSM-deficient miceViral respiratory infectionsTriggered by infectionInflammation-induced pathologyLung epithelial cellsIFN-I responseIFN-I signalingRegulation of inflammationType I interferonPoly(I:CAcute blockadeCytokine oncostatin MRespiratory infectionsUncontrolled inflammationInflammatory responseI interferonInterferon responseRespiratory tractMice
2021
Microenvironment controls inflammatory response in macrophages
Zhou X, Pope S, Medzhitov R. Microenvironment controls inflammatory response in macrophages. The Journal Of Immunology 2021, 206: 111.03-111.03. DOI: 10.4049/jimmunol.206.supp.111.03.Peer-Reviewed Original ResearchInflammatory gene expressionInflammatory responseInflammatory response to lipopolysaccharideGene expressionModulate immune functionResponse to lipopolysaccharideControlling inflammatory gene expressionControlling inflammatory responsesTissue environmentPH-sensing receptorImmune cellsInflammatory conditionsInflammatory programGene-specific mannerTissue dysfunctionImmune functionNF-kBTissue microenvironmentPathway activationNarrow homeostatic rangeChromatin landscapeGene classesTissue homeostasisTranscriptional circuitsChromatin remodeling
2000
The Toll receptor family and microbial recognition
Medzhitov R, Janeway C. The Toll receptor family and microbial recognition. Trends In Microbiology 2000, 8: 452-456. PMID: 11044679, DOI: 10.1016/s0966-842x(00)01845-x.Peer-Reviewed Original Research
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