2025
Hospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury
Mathis M, Mentz G, Cao J, Balczewski E, Janda A, Likosky D, Schonberger R, Hawkins R, Heung M, Ailawadi G, Ladhania R, Sjoding M, Kheterpal S, Singh K, Sundt T, Fitzsimons M, Shann K, Kumar V, Yarboro L, Naik B, Tibayan F, Aziz M, Mulligan M, Jelacic S, Kaneko T, Graetz T, Assi R, Mallidi H, Querejeta-Roca G, Shook D, Tsai C, Jewell E, Wanderer J, Freundlich R, Rock P, Douville N, Fisher C, Pace N, Domino K, Wagener G, King C, O'Reilly-Shah V, Bardia A, Clark D. Hospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury. JAMA Network Open 2025, 8: e258342. PMID: 40314957, PMCID: PMC12048843, DOI: 10.1001/jamanetworkopen.2025.8342.Peer-Reviewed Original ResearchImplementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Presurgical Evaluation Clinic: Feasibility Cohort Study
Carr Z, Agarkov D, Li J, Charchaflieh J, Brenes-Bastos A, Freund J, Zafar J, Schonberger R, Heerdt P. Implementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Presurgical Evaluation Clinic: Feasibility Cohort Study. JMIR Perioperative Medicine 2025, 8: e65805. PMID: 39773953, PMCID: PMC11888076, DOI: 10.2196/65805.Peer-Reviewed Original ResearchConceptsDuke Activity Status IndexPeak oxygen uptakePeak METsEvaluation clinicParticipant satisfactionOxygen uptakeSubmaximal cardiopulmonary exercise testingFunctional capacity assessmentLow functional capacityCardiopulmonary exercise testingPerceived exertionMET assessmentStructured surveyCapacity surveyMedian patient satisfactionProvider-drivenExercise testMean session timePearson correlation coefficientSurvey scoresCardiopulmonary testFunctional capacityPatient satisfactionCohort studyInclusion criteria
2024
Multicenter Analysis of the Relationship Between Operative Team Familiarity and Safety and Efficiency Outcomes in Cardiac Surgery
Bauer T, Janda A, Wu X, Ling C, Shook D, Querejeta-Roca G, Shann K, Smith T, Mathis M, Kaneko T, Sundt T, Schonberger R, Harrington S, Dias R, Pagani F, Likosky D, Yule S, Caldwell M, Corso J, Louis N, Krein S, Manojlovich M, Stakich-Alpirez K, Sturmer D, Yalamuri S, Lawton J, Abernathy J, Cleveland J, Clendenen N, Justison G, Fried M, Nemeh H, Fitzsimons M, Dickinson T, Stulak J, de la Cruz K. Multicenter Analysis of the Relationship Between Operative Team Familiarity and Safety and Efficiency Outcomes in Cardiac Surgery. Circulation Cardiovascular Quality And Outcomes 2024, 17: e011065. PMID: 39689169, PMCID: PMC11654451, DOI: 10.1161/circoutcomes.124.011065.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnesthesiologistsCardiac Surgical ProceduresCardiopulmonary BypassClinical CompetenceCooperative BehaviorFemaleHealth Knowledge, Attitudes, PracticeHumansInterdisciplinary CommunicationMaleMiddle AgedOperative TimeOutcome and Process Assessment, Health CarePatient Care TeamPatient SafetyPostoperative ComplicationsQuality Indicators, Health CareRegistriesRetrospective StudiesRisk AssessmentRisk FactorsSurgeonsTime FactorsTreatment OutcomeUnited StatesConceptsSociety of Thoracic SurgeonsCardiopulmonary bypass durationTeam familiarityBypass durationElectronic health record dataHealth record dataEffective team dynamicsSociety of Thoracic Surgeons morbidityCardiac Surgery RegistryComposite major morbidityCardiac surgical proceduresMortality measuresLinear regression modelsCrude analysisQuaternary hospitalRecord dataRisk adjustmentPrimary outcomePatient outcomesProcedural efficiencyMajor morbidityCardiac surgeryCardiac operationsMulticenter analysisPatient ageInternational multi-institutional external validation of preoperative risk scores for 30-day in-hospital mortality in paediatric patients
Tangel V, Hoeks S, Stolker R, Brown S, Pryor K, de Graaff J, Committee M, Pace N, Domino K, Muehlschlegel J, Kheterpal S, Vaughan M, Mathis M, Jiang S, Obembe S, Freundlich R, Schonberger R, Kim D. International multi-institutional external validation of preoperative risk scores for 30-day in-hospital mortality in paediatric patients. British Journal Of Anaesthesia 2024, 133: 1222-1233. PMID: 39477712, DOI: 10.1016/j.bja.2024.09.003.Peer-Reviewed Original ResearchConceptsSurgical risk scoresPediatric risk assessmentArea under the receiver operating characteristic curveIn-hospital mortalityRisk scoreMulticenter Perioperative Outcomes GroupPreoperative risk scoreDecision curve analysisReceiver operating characteristic curvePhysical status scoreExternal validationAssess model discriminationRisk prediction scoreASA physical status scoreClinical decision-makingPaediatric patientsLow probability of mortalityDutch hospitalsOutcome groupPatient-specific risk scoresPrimary outcomeClustering of casesCurve analysisStatus scoreCharacteristic curvePreoperative Blood Pressures and the Physician Anesthesiologist
Schonberger R. Preoperative Blood Pressures and the Physician Anesthesiologist. Anesthesiology 2024, 141: 208-210. PMID: 38980164, PMCID: PMC11239125, DOI: 10.1097/aln.0000000000005101.Peer-Reviewed Original Research
2023
Perioperative Mortality of the COVID-19 Recovered Patient Compared to a Matched Control: A Multicenter Retrospective Cohort Study
Aziz M, Schenning K, Koike S, O’Glasser A, O’Reilly-Shah V, Sera V, Mathis M, Naik B, Taicher B, Colquhoun D, Freundlich R, Schonberger R, Domino K, Chen L, Pace N. Perioperative Mortality of the COVID-19 Recovered Patient Compared to a Matched Control: A Multicenter Retrospective Cohort Study. Anesthesiology 2023, 140: 195-206. PMID: 37844271, DOI: 10.1097/aln.0000000000004809.Peer-Reviewed Original ResearchConceptsAcute kidney injuryPulmonary complicationsKidney injuryIncreased riskPerioperative mortalityExposed patientsCOVID-19 infectionIncreased 30-day mortality riskElective surgeryIncreased risk of acute kidney injuryIncreased risk of pulmonary complicationsRisk of acute kidney injuryMortality riskPositive testRisk of pulmonary complicationsRisk of perioperative mortalityRetrospective observational cohort studyThirty-day mortalityCOVID-19-recovered patientsCohort of patientsExposure to COVID-19 infectionIncreased risk of mortalityAssociated with increased mortality riskObservational cohort studyElective inpatient surgeryHypoxemia in School-age Children Undergoing One-lung Ventilation: A Retrospective Cohort Study from the Multicenter Perioperative Outcomes Group
Templeton T, Krol B, Miller S, Lee L, Mathis M, Vishneski S, Chatterjee D, Gupta R, Shroeder R, Saha A, Schonberger R. Hypoxemia in School-age Children Undergoing One-lung Ventilation: A Retrospective Cohort Study from the Multicenter Perioperative Outcomes Group. Anesthesiology 2023, 140: 25-37. PMID: 37738432, DOI: 10.1097/aln.0000000000004781.Peer-Reviewed Original ResearchConceptsIncreased risk of hypoxemiaOne-lung ventilationRisk of hypoxemiaRight-sided casesIncreased riskSevere hypoxemiaDuration of one-lung ventilationVideo-assisted thoracoscopic surgeryRoom air oxygen saturationLow tidal volume ventilationRisk factorsOxygen saturationMulticenter Perioperative Outcomes Group databasePrevalence of hypoxemiaAssociated with hypoxemiaAssociated with increased riskTidal volume ventilationRetrospective cohort studySelection operator regression analysisChildren 4Nonmodifiable risk factorsMultivariate least absolute shrinkageSchool-aged childrenThoracoscopic surgeryThoracic surgeryPatient-, Clinician-, and Institution-level Variation in Inotrope Use for Cardiac Surgery: A Multicenter Observational Analysis
Mathis M, Janda A, Kheterpal S, Schonberger R, Pagani F, Engoren M, Mentz G, Shook D, Muehlschlegel J, Group M. Patient-, Clinician-, and Institution-level Variation in Inotrope Use for Cardiac Surgery: A Multicenter Observational Analysis. Anesthesiology 2023, 139: 122-141. PMID: 37094103, PMCID: PMC10524016, DOI: 10.1097/aln.0000000000004593.Peer-Reviewed Original ResearchConceptsInotrope useCardiac surgeryHome medicationsAdjusted median odds ratioPulmonary circulation disordersAdult cardiac surgeryMechanical circulatory supportMedian odds ratioMedical school affiliationHome inotropesInotrope infusionInotrope therapyInotropic therapyCardiopulmonary bypassHeart failureMulticenter cohortPrimary outcomeCirculatory supportBlack raceCirculation disordersOdds ratioCommunity hospitalObservational studySame patientPatients
2022
Geospatial analysis of patients’ social determinants of health for health systems science and disparity research
Pearson J, Jacobson C, Ugochukwu N, Asare E, Kan K, Pace N, Han J, Wan N, Schonberger R, Andreae M. Geospatial analysis of patients’ social determinants of health for health systems science and disparity research. International Anesthesiology Clinics 2022, 61: 49-62. PMID: 36480649, PMCID: PMC10107426, DOI: 10.1097/aia.0000000000000389.Peer-Reviewed Original ResearchOxygen administration during surgery and postoperative organ injury: observational cohort study
McIlroy D, Shotwell M, Lopez M, Vaughn M, Olsen J, Hennessy C, Wanderer J, Semler M, Rice T, Kheterpal S, Billings F, Group M, Cuff G, Freundlich R, Kurz A, Naik B, Mathis M, Schonberger R. Oxygen administration during surgery and postoperative organ injury: observational cohort study. The BMJ 2022, 379: e070941. PMID: 36450405, PMCID: PMC9710248, DOI: 10.1136/bmj-2022-070941.Peer-Reviewed Original ResearchConceptsAcute kidney injuryObservational cohort studyLung injuryKidney injuryMyocardial injuryOxygen administrationGreater oddsCohort studyMedian age 59 yearsHospital discharge diagnosis codesGlobal Outcomes criteriaAge 59 yearsHours of surgeryDischarge diagnosis codesPotential confounding variablesHemoglobin oxygen saturationPostoperative kidneyPrimary endpointAdult patientsMedian durationOrgan injurySerum troponinEndotracheal intubationGeneral anesthesiaKidney diseaseAssociation between choice of reversal agent for neuromuscular block and postoperative pulmonary complications in patients at increased risk undergoing non-emergency surgery: STIL-STRONGER, a multicentre matched cohort study
Colquhoun D, Vaughn M, Bash L, Janda A, Shah N, Ghaferi A, Sjoding M, Mentz G, Kheterpal S, Committee M, Craft R, Domino K, Freundlich R, Mathis M, McCormick P, Naik B, Ruiz J, Schonberger R, Schroeder R, Stewart A, Taicher B, Tingle S, Togioka B, Urman R, Vachhani S. Association between choice of reversal agent for neuromuscular block and postoperative pulmonary complications in patients at increased risk undergoing non-emergency surgery: STIL-STRONGER, a multicentre matched cohort study. British Journal Of Anaesthesia 2022, 130: e148-e159. PMID: 35691703, PMCID: PMC9875908, DOI: 10.1016/j.bja.2022.04.023.Peer-Reviewed Original ResearchConceptsPostoperative pulmonary complicationsPulmonary complicationsNon-emergency surgeryRespiratory failureCohort studyNeuromuscular blockReversal agentsAnesthesiologists physical status 3Primary composite outcomeCohort of patientsUse of sugammadexIntra-abdominal surgeryOccurrence of pneumoniaBody mass indexSource of morbidityNeuromuscular blocking agentsStatus 3Complication outcomesComposite outcomeMajor surgeryPrimary outcomeMass indexTracheal intubationGeneral anesthesiaMulticenter Perioperative Outcomes Group
2021
Trends in personal protective equipment use by clinicians performing airway procedures for patients with coronavirus disease 2019 in the USA from the intubateCOVID registry
Gaulton T, Neuman M, Investigators I, Gaulton T, Neuman M, Lane-Fall M, Gaskins L, Dattilo J, El-Boghdadly K, Wong D, Ahmad I, Johnstone C, Gutstein H, Muehlschlegel J, Hua M, Fonseca L, Mitrev L, Low Y, Gupta D, Ayad S, Volio A, Salih A, Kim D, Nutcharoen A, Skolaris A, Sherman M, Giska M, Nowak K, Chhina A, Guruswamy J, Penning D, Majewski M, Nagrebetsky A, Houle T, Aziz M, Freed J, Lien C, Mihm F, Desai P, Fahy B, Davies L, Adair K, Gunnett A, Mhyre J, Sharawi N, Applegate R, Brzenski A, Lin M, Olmos A, Chen C, Gropper M, Shochat G, Hoefnagel A, Ranganath Y, Sibenellar Z, Colquhoun D, Cloyd B, Healy D, Mathis M, Schechtman S, Steadman J, Stuart A, Bott S, Gerety L, Fisher J, Friend A, Breidenstein M, Domino K, Cervantes V, Joffe A, Dutton R, Shanahan J, Leissner K, Jaffe J, Strathman A, Khanna A, Segal B, Harris L, Fowler J, Johnson K, Hill S, Murrell M, Panzica P, Mittnacht A, Abramowicz E, Wecksell M, Schonberger R, Li J, Michel S, Treggiari M, Berstein S, Dashevksy M. Trends in personal protective equipment use by clinicians performing airway procedures for patients with coronavirus disease 2019 in the USA from the intubateCOVID registry. British Journal Of Anaesthesia 2021, 126: e184-e186. PMID: 33612248, PMCID: PMC8052559, DOI: 10.1016/j.bja.2021.01.019.Peer-Reviewed Original Research
2019
Preoperative chlorhexidine mouthwash to reduce pneumonia after cardiac surgery: A systematic review and meta-analysis
Bardia A, Blitz D, Dai F, Hersey D, Jinadasa S, Tickoo M, Schonberger RB. Preoperative chlorhexidine mouthwash to reduce pneumonia after cardiac surgery: A systematic review and meta-analysis. Journal Of Thoracic And Cardiovascular Surgery 2019, 158: 1094-1100. PMID: 30826096, DOI: 10.1016/j.jtcvs.2019.01.014.Peer-Reviewed Original ResearchConceptsPreoperative chlorhexidine mouthwashChlorhexidine gluconate mouthwashPostoperative pneumoniaCardiac surgeryChlorhexidine mouthwashHealth care burdenQuality of evidenceComprehensive systematic searchRandom-effects modelPreoperative chlorhexidineRecommendations AssessmentCommon complicationPrimary outcomePreoperative protocolPatient morbidityRisk ratioPatient outcomesCare burdenReduced riskIndependent reviewersCumulative IndexPneumoniaNLM PubMedChlorhexidine gluconatePatientsSuccinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review.
Larach M, Klumpner T, Brandom B, Vaughn M, Belani K, Herlich A, Kim T, Limoncelli J, Riazi S, Sivak E, Capacchione J, Mashman D, Kheterpal S, Kooij F, Wilczak J, Soto R, Berris J, Price Z, Lins S, Coles P, Harris J, Cummings K, Berman M, Nanamori M, Adelman B, Wedeven C, LaGorio J, McCormick P, Tom S, Aziz M, Coffman T, Ellis T, Molina S, Peterson W, Mackey S, van Klei W, Ginde A, Biggs D, Neuman M, Craft R, Pace N, Paganelli W, Durieux M, Nair B, Wanderer J, Miller S, Helsten D, Turnbull Z, Schonberger R. Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review. Anesthesiology 2019, 130: 41-54. PMID: 30550426, DOI: 10.1097/aln.0000000000002490.Peer-Reviewed Original ResearchConceptsMalignant hyperthermiaAirway rescueDantrolene treatmentMask ventilationMH casesVolatile anestheticsNorth American MH RegistryDifficult mask ventilationClinical grading scaleMalignant Hyperthermia AssociationAnesthesia Closed Claims ProjectStocking dantroleneMH eventsDantrolene administrationDantroleneOverall mortalityMulticenter Perioperative Outcomes GroupOutcome groupSuccinylcholine useGrading scaleU.S. patientsTreat MHClosed Claims ProjectSuccinylcholineAirway
2018
Quantification of Postmembrane Gaseous Microembolization During Venoarterial Extracorporeal Membrane Oxygenation
Jiao Y, Gipson KE, Bonde P, Mangi A, Hagberg R, Rosinski DJ, Gross JB, Schonberger RB. Quantification of Postmembrane Gaseous Microembolization During Venoarterial Extracorporeal Membrane Oxygenation. ASAIO Journal 2018, 64: 31-37. PMID: 28557862, DOI: 10.1097/mat.0000000000000598.Peer-Reviewed Original ResearchConceptsVenoarterial extracorporeal membrane oxygenationVA-ECMO patientsExtracorporeal membrane oxygenationGaseous microemboliVA-ECMOECMO patientsMembrane oxygenationCardiopulmonary bypassAdult VA-ECMO patientsExtracorporeal membrane oxygenation circuitEnd-organ dysfunctionInstitutional review board approvalRoutine patient careMembrane oxygenation circuitPatient care eventsPatient care activitiesReview board approvalOrgan dysfunctionEmbolic rateClinical eventsObservational studyIntravenous injectionEnd organsGME volumeBoard approval
2017
Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) in Adult Patients – Many Questions, Few Answers, and Hard Choices
Bardia A, Schonberger RB. Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) in Adult Patients – Many Questions, Few Answers, and Hard Choices. Journal Of Cardiothoracic And Vascular Anesthesia 2017, 32: 1183-1184. PMID: 29276089, DOI: 10.1053/j.jvca.2017.10.037.Peer-Reviewed Original ResearchThe effect of race on postsurgical ambulatory medical follow-up among United States Veterans
Schonberger RB, Dai F, Brandt C, Burg MM. The effect of race on postsurgical ambulatory medical follow-up among United States Veterans. Journal Of Clinical Anesthesia 2017, 40: 55-61. PMID: 28625448, PMCID: PMC5490668, DOI: 10.1016/j.jclinane.2016.11.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAmbulatory CareBlack or African AmericanComorbidityContinuity of Patient CareFemaleFollow-Up StudiesHealthcare DisparitiesHumansLong-Term CareMaleMiddle AgedPatient Acceptance of Health CareRetrospective StudiesSurgical Procedures, OperativeUnited StatesVeteransVeterans HealthYoung AdultConceptsAfrican American raceAfrican American patientsInternal medicineAmerican patientsAmbulatory internal medicineAmerican raceUS Veterans Affairs hospitalsYear of surgeryDay of surgeryVeterans Affairs hospitalUnited States veteransQuality improvement initiativesRetrospective observationalUS veteransHispanic ethnicityInpatient daysStates veteransSurgeryDecreased likelihoodEffect of raceImprovement initiativesVeteransFurther studiesPatientsAfrican AmericansA Pilot Analysis of the Association Between Types of Monitored Anesthesia Care Drugs and Outcomes in Transfemoral Aortic Valve Replacement Performed Without General Anesthesia
Chen EY, Sukumar N, Dai F, Akhtar S, Schonberger RB. A Pilot Analysis of the Association Between Types of Monitored Anesthesia Care Drugs and Outcomes in Transfemoral Aortic Valve Replacement Performed Without General Anesthesia. Journal Of Cardiothoracic And Vascular Anesthesia 2017, 32: 666-671. PMID: 29277298, PMCID: PMC5766429, DOI: 10.1053/j.jvca.2017.07.009.Peer-Reviewed Original ResearchConceptsTransfemoral aortic valve replacementMonitored Anesthesia CareAortic valve replacementGeneral anesthesiaValve replacementAge incrementsMedication dose adjustmentUse of dexmedetomidineRetrospective observational studyType of sedationTertiary teaching hospitalHospital lengthPostoperative deliriumTAVR patientsDose adjustmentConscious sedationAnesthesia careCare drugsPossible differential effectsTeaching hospitalObservational studyAnesthetic agentsDose reductionDrug dosingPilot analysisOrthogonal Views of Coronary Vessels
Maracaja Neto L, Modak R, Schonberger R. Orthogonal Views of Coronary Vessels. Anesthesia & Analgesia 2017, 124: 1087-1090. PMID: 28099289, DOI: 10.1213/ane.0000000000001872.Peer-Reviewed Original ResearchConceptsCoronary arteryLeft atrial appendage ligationMitral valve surgeryTranscatheter aortic valve implantationAortic valve implantationRight coronary arteryLeft anterior descendingDelivery of cardioplegiaAortic proceduresCoronary blood flowValve surgeryCoronary buttonsTransesophageal echocardiographyLeft main coronary artery bifurcationBlood cardioplegiaCircumflex coronary arteryCoronary sinusRetrograde cardioplegiaCardiac interventionsValve implantationAnterior descendingCoronary imagingBlood flowCardioplegiaCoronary artery bifurcations
2016
A Retrospective Observational Study of Anesthetic Induction Dosing Practices in Female Elderly Surgical Patients: Are We Overdosing Older Patients?
Akhtar S, Heng J, Dai F, Schonberger RB, Burg MM. A Retrospective Observational Study of Anesthetic Induction Dosing Practices in Female Elderly Surgical Patients: Are We Overdosing Older Patients? Drugs & Aging 2016, 33: 737-746. PMID: 27581549, DOI: 10.1007/s40266-016-0394-x.Peer-Reviewed Original ResearchConceptsDoses of fentanylOlder patientsFemale patientsInduction dosesGeneral anesthesiaObservational studyTertiary care academic hospitalElderly surgical patientsIncidence of hypotensionDose of propofolRetrospective observational studyOld female patientIntravenous anesthetic agentPost-induction hypotensionAge-associated differencesQuality improvement effortsResultsOlder patientsVasopressor therapyElderly patientsSurgical patientsYounger patientsBlood pressureHemodynamic outcomesASA-PSStudy designWe
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply