2025
Hospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury
Mathis M, Mentz G, Cao J, Balczewski E, Janda A, Likosky D, Schonberger R, Hawkins R, Heung M, Ailawadi G, Ladhania R, Sjoding M, Kheterpal S, Singh K, Sundt T, Fitzsimons M, Shann K, Kumar V, Yarboro L, Naik B, Tibayan F, Aziz M, Mulligan M, Jelacic S, Kaneko T, Graetz T, Assi R, Mallidi H, Querejeta-Roca G, Shook D, Tsai C, Jewell E, Wanderer J, Freundlich R, Rock P, Douville N, Fisher C, Pace N, Domino K, Wagener G, King C, O'Reilly-Shah V, Bardia A, Clark D. Hospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury. JAMA Network Open 2025, 8: e258342. PMID: 40314957, PMCID: PMC12048843, DOI: 10.1001/jamanetworkopen.2025.8342.Peer-Reviewed Original ResearchConceptsAcute kidney injuryClinician-level variationAssociated with acute kidney injuryAcute kidney injury ratesCardiac surgeryIntraclass correlation coefficientAdult patientsKidney injuryCohort studyCohort study of adult patientsResuscitation practicesPostoperative acute kidney injuryOperating room practiceStudy of adult patientsAssociated with increased morbidityCardiac surgical proceduresCardiac surgical databasePractice variationRBC transfusion ratesFluid volume administrationHospital-level variationMultilevel mixed-effects modelsPatient-level characteristicsRisk-adjustment modelsHealth care costs
2023
Perioperative Mortality of the COVID-19 Recovered Patient Compared to a Matched Control: A Multicenter Retrospective Cohort Study
Aziz M, Schenning K, Koike S, O’Glasser A, O’Reilly-Shah V, Sera V, Mathis M, Naik B, Taicher B, Colquhoun D, Freundlich R, Schonberger R, Domino K, Chen L, Pace N. Perioperative Mortality of the COVID-19 Recovered Patient Compared to a Matched Control: A Multicenter Retrospective Cohort Study. Anesthesiology 2023, 140: 195-206. PMID: 37844271, DOI: 10.1097/aln.0000000000004809.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryCOVID-19Elective Surgical ProceduresHumansPostoperative ComplicationsRetrospective StudiesConceptsAcute kidney injuryPulmonary complicationsKidney injuryIncreased riskPerioperative mortalityExposed patientsCOVID-19 infectionIncreased 30-day mortality riskElective surgeryIncreased risk of acute kidney injuryIncreased risk of pulmonary complicationsRisk of acute kidney injuryMortality riskPositive testRisk of pulmonary complicationsRisk of perioperative mortalityRetrospective observational cohort studyThirty-day mortalityCOVID-19-recovered patientsCohort of patientsExposure to COVID-19 infectionIncreased risk of mortalityAssociated with increased mortality riskObservational cohort studyElective inpatient surgery
2022
Oxygen administration during surgery and postoperative organ injury: observational cohort study
McIlroy D, Shotwell M, Lopez M, Vaughn M, Olsen J, Hennessy C, Wanderer J, Semler M, Rice T, Kheterpal S, Billings F, Group M, Cuff G, Freundlich R, Kurz A, Naik B, Mathis M, Schonberger R. Oxygen administration during surgery and postoperative organ injury: observational cohort study. The BMJ 2022, 379: e070941. PMID: 36450405, PMCID: PMC9710248, DOI: 10.1136/bmj-2022-070941.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgedCohort StudiesFemaleHeart InjuriesHumansLung InjuryMiddle AgedOxygenPostoperative PeriodConceptsAcute kidney injuryObservational cohort studyLung injuryKidney injuryMyocardial injuryOxygen administrationGreater oddsCohort studyMedian age 59 yearsHospital discharge diagnosis codesGlobal Outcomes criteriaAge 59 yearsHours of surgeryDischarge diagnosis codesPotential confounding variablesHemoglobin oxygen saturationPostoperative kidneyPrimary endpointAdult patientsMedian durationOrgan injurySerum troponinEndotracheal intubationGeneral anesthesiaKidney disease
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