2022
Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden
Nichter B, Koller D, De Angelis F, Wang J, Girgenti M, Na P, Hill M, Norman S, Krystal J, Gelernter J, Polimanti R, Pietrzak R. Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden. Psychological Medicine 2022, 53: 6325-6333. PMID: 36444557, DOI: 10.1017/s0033291722003646.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresUS military veteransLifetime suicide attemptsSuicide attemptsTrauma exposureTrauma burdenGenetic liabilityMilitary veteransDrug repurposing analysisPopulation-based sampleCumulative trauma exposureLifetime trauma exposureLow trauma exposureSuicide prediction modelsChronic inflammationInflammatory processNervous system developmentRisk scorePsychiatric characteristicsSuicidal behaviorExposure interactionsLarge genome-wide association studiesHigh levelsVeteransSuicidality
2011
Medical Comorbidity of Full and Partial Posttraumatic Stress Disorder in US Adults
Pietrzak RH, Goldstein RB, Southwick SM, Grant BF. Medical Comorbidity of Full and Partial Posttraumatic Stress Disorder in US Adults. Psychosomatic Medicine 2011, 73: 697-707. PMID: 21949429, PMCID: PMC3188699, DOI: 10.1097/psy.0b013e3182303775.Peer-Reviewed Original ResearchConceptsLifetime trauma exposureMedical conditionsUS adultsPartial PTSDTrauma exposureAngina pectorisStomach ulcersHuman immunodeficiency virus seropositivityNoncirrhotic liver diseaseDiagnosis of hypertensionPartial posttraumatic stress disorderWave 2 National Epidemiologic SurveyLogistic regression analysisPast-year diagnosesNational Epidemiologic SurveyNumerous medical conditionsPosttraumatic stress disorderIntermediate oddsMedical comorbiditiesDiabetes mellitusLiver diseaseVirus seropositivityHeart diseaseAxis IEpidemiologic Survey