2025
Engineering Mice to Study Human Immunity.
Sefik E, Xiao T, Chiorazzi M, Odell I, Zhang F, Agrawal K, Micevic G, Flavell R. Engineering Mice to Study Human Immunity. Annual Review Of Immunology 2025 PMID: 40020225, DOI: 10.1146/annurev-immunol-082523-124415.Peer-Reviewed Original ResearchHumanized miceHuman hematopoiesisImmune responseImmune systemHumanized mouse modelHuman hematopoietic stemImmunocompromised murine hostsResident immune cellsHuman immune responseStudy human immunityHuman immune systemIntegration of multi-omicsHematopoietic stemImmune cell growthImmune cellsEngineered miceProgenitor cellsMouse modelImmunological diseasesMurine hostCancer treatmentPreclinical drugsHuman immunityMiceModel disease
2023
ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m6A modification-mediated RNA stability control
Gao Y, Zimmer J, Vasic R, Liu C, Gbyli R, Zheng S, Patel A, Liu W, Qi Z, Li Y, Nelakanti R, Song Y, Biancon G, Xiao A, Slavoff S, Kibbey R, Flavell R, Simon M, Tebaldi T, Li H, Halene S. ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m6A modification-mediated RNA stability control. Cell Reports 2023, 42: 113163. PMID: 37742191, PMCID: PMC10636609, DOI: 10.1016/j.celrep.2023.113163.Peer-Reviewed Original ResearchConceptsAlkB homolog 5Post-transcriptional regulatory mechanismsHematopoietic stemNumerous cellular processesProgenitor cell fitnessEnergy metabolismMitochondrial ATP productionMethyladenosine (m<sup>6</sup>A) RNA modificationTricarboxylic acid cycleCell energy metabolismHuman hematopoietic cellsMitochondrial energy productionCell fitnessCellular processesRNA modificationsRNA methylationRegulatory mechanismsEnzyme transcriptsATP productionHomolog 5Acid cycleΑ-ketoglutarateHematopoietic cellsMessenger RNAΑ-KG
2010
Human Thrombopoietin Knockin Mice Efficiently Support Human Hematopoiesis In Vivo
Rongvaux A, Willinger T, Takizawa H, Rathinam C, Eynon E, Stevens S, Manz M, Flavell R. Human Thrombopoietin Knockin Mice Efficiently Support Human Hematopoiesis In Vivo. Blood 2010, 116: 403. DOI: 10.1182/blood.v116.21.403.403.Peer-Reviewed Original ResearchHematopoietic stem cellsHuman hematopoietic stemHematopoietic stemSelf-renewal capacityHuman hematopoiesisHuman cellsMultilineage differentiationHematopoietic cellsField of hematopoiesisLong-term hematopoietic stem cellsHuman CD34Progenitor cell biologyStem cellsProgenitor cellsHuman hematopoietic cellsHuman hematopoietic stem cellsHuman thrombopoietinHuman homologuePopulation of cellsCell biologyEnhanced self-renewal capacityFunctional analysisSecondary recipientsLymphoid lineageXenogeneic environment
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