2024
MULTIMODALITY IMAGING GUIDED INTRAMYOCARDIAL DELIVERY OF IMAGEABLE HYDROGEL POST MYOCARDIAL INFARCTION IMPROVES STRAIN ASSOCIATED WITH INTEGRIN ACTIVATION
Melvinsdottir I, Midgett D, Lee S, Chen K, Avendano R, Ahn S, Thorn S, Uman S, Sinusas A. MULTIMODALITY IMAGING GUIDED INTRAMYOCARDIAL DELIVERY OF IMAGEABLE HYDROGEL POST MYOCARDIAL INFARCTION IMPROVES STRAIN ASSOCIATED WITH INTEGRIN ACTIVATION. Journal Of The American College Of Cardiology 2024, 83: 1399. DOI: 10.1016/s0735-1097(24)03389-8.Peer-Reviewed Original Research
2023
Improvement in cardiac function and regional LV strain following intramyocardial injection of a theranostic hydrogel early postmyocardial infarction in a porcine model
Avendaño R, Midgett D, Melvinsdottir I, Thorn S, Uman S, Pickell Z, Lee S, Liu Z, Mamarian M, Duncan J, Spinale F, Burdick J, Sinusas A. Improvement in cardiac function and regional LV strain following intramyocardial injection of a theranostic hydrogel early postmyocardial infarction in a porcine model. Journal Of Applied Physiology 2023, 135: 405-420. PMID: 37318987, PMCID: PMC10538987, DOI: 10.1152/japplphysiol.00342.2022.Peer-Reviewed Original ResearchConceptsMyocardial infarctionIntramyocardial deliveryLV hemodynamicsControl groupFunctional indexEarly post-myocardial infarctionSystolic functional indicesMyocardial performance indexAnterolateral myocardial infarctionLeft anterior descendingPressure-volume loop areaLeft ventricular remodelingGlobal LV functionLV functional changesPost-myocardial infarctionSupply/demand ratioRegional LV strainHydrogel groupTei indexEjection fractionHeart failureAnterior descendingCircumflex arteryLV functionAortic pressure
2022
Quantification of intramyocardial blood volume using 99mTc-RBC SPECT/CT: a pilot human study
Yousefi H, Shi L, Soufer A, Tsatkin V, Bruni W, Avendano R, Greco K, McMahon D, Thorn S, Miller E, Sinusas A, Liu C. Quantification of intramyocardial blood volume using 99mTc-RBC SPECT/CT: a pilot human study. Journal Of Nuclear Cardiology 2022, 30: 292-297. PMID: 36319815, DOI: 10.1007/s12350-022-03123-0.Peer-Reviewed Original ResearchCineCT platform for in vivo and ex vivo measurement of 3D high resolution Lagrangian strains in the left ventricle following myocardial infarction and intramyocardial delivery of theranostic hydrogel
Midgett D, Thorn S, Ahn S, Uman S, Avendano R, Melvinsdottir I, Lysyy T, Kim J, Duncan J, Humphrey J, Papademetris X, Burdick J, Sinusas A. CineCT platform for in vivo and ex vivo measurement of 3D high resolution Lagrangian strains in the left ventricle following myocardial infarction and intramyocardial delivery of theranostic hydrogel. Journal Of Molecular And Cellular Cardiology 2022, 166: 74-90. PMID: 35227737, PMCID: PMC9035115, DOI: 10.1016/j.yjmcc.2022.02.004.Peer-Reviewed Original Research
2021
Novel SPECT and PET Tracers and Myocardial Imaging
Melvinsdottir I, Avendaño R, Sinusas A. Novel SPECT and PET Tracers and Myocardial Imaging. 2021, 189-228. DOI: 10.1007/978-3-030-83167-7_11.Peer-Reviewed Original ResearchPositron emission tomographyPET imagingMultimodality cardiovascular imagingSingle photon emissionRisk stratificationPathophysiological changesCardiac functionMyocardial remodelingMyocardial diseaseAutonomic regulationMyocardial imagingEmission tomographyHigh-resolution anatomicalMyocardial flowCardiovascular imagingPET tracersNovel SPECTMolecular changesSPECTPhoton emissionHybrid imaging technologyCell deathVivo detectionMolecular imagingImaging
2020
Application Of Cine CT Imaging For Evaluation Of Biomechanics Of The Left Ventricle Post Myocardial Infarction And Following Intramyocardial Delivery Of Imageable Hydrogel
Midgett D, Sinusas A, Melvinsdottir I, Avendano R, Lee S. Application Of Cine CT Imaging For Evaluation Of Biomechanics Of The Left Ventricle Post Myocardial Infarction And Following Intramyocardial Delivery Of Imageable Hydrogel. Journal Of Cardiovascular Computed Tomography 2020, 14: s28-s29. DOI: 10.1016/j.jcct.2020.06.035.Peer-Reviewed Original Research
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