2025
W139 Guanfacine Reduces Drug Craving, Stress and Increases the Number of Abstinence Days in Women With Polysubstance Use Disorder (PSUD): A Pilot 2-Site Clinical Study
Wemm S, Fogelman N, Sullivan L, Vacey E, Bera S, Hermes G, Swain J, Fox H, Sinha R. W139 Guanfacine Reduces Drug Craving, Stress and Increases the Number of Abstinence Days in Women With Polysubstance Use Disorder (PSUD): A Pilot 2-Site Clinical Study. Drug And Alcohol Dependence 2025, 267: 112081. DOI: 10.1016/j.drugalcdep.2024.112081.Peer-Reviewed Original ResearchM125 Guanfacine Improves Stroop Performance That in Turn Moderates Drug Treatment Effect on Cumulative Abstinence in Women With Polysubstance Use Disorder
Fogelman N, McGowan C, Wemm S, Tate M, Hermes G, Sinha R, Wemm S. M125 Guanfacine Improves Stroop Performance That in Turn Moderates Drug Treatment Effect on Cumulative Abstinence in Women With Polysubstance Use Disorder. Drug And Alcohol Dependence 2025, 267: 111719. DOI: 10.1016/j.drugalcdep.2024.111719.Peer-Reviewed Original ResearchRole of Altered Neural Circuits of Stress and Reward Regulation in Alcohol Use Disorder and Treatment-Related Recovery
Seo D, Choi J, Sinha R, De Aquiar R. Role of Altered Neural Circuits of Stress and Reward Regulation in Alcohol Use Disorder and Treatment-Related Recovery. Drug And Alcohol Dependence 2025, 267: 112197. DOI: 10.1016/j.drugalcdep.2024.112197.Peer-Reviewed Original ResearchPregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder
Gao H, Sinha R, Wemm S, Milivojevic V. Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder. Alcohol Clinical And Experimental Research 2025, 49: 619-628. PMID: 39779217, PMCID: PMC11928267, DOI: 10.1111/acer.15529.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment-seeking individualsAlcohol cuesAlcohol cravingResponse to stressPregnenolone groupUse disorderResponse to alcohol cuesGroup x condition interactionHigher alcohol cravingLinear mixed-effects modelsHeart rate variabilityHeart rate variability indicesAutonomic nervous system dysregulationChronic alcohol consumptionRandomized to placeboAutonomic nervous system responsesNervous system dysregulationCravingAlcohol's impactCondition interactionAssociated with autonomic nervous system dysregulationNervous system responsesAutonomic responsesEnhanced autonomic function
2024
Neural responses to stress and alcohol cues in individuals with pain with and without alcohol use disorder
Radoman M, McGowan C, Heilner E, Lacadie C, Sinha R. Neural responses to stress and alcohol cues in individuals with pain with and without alcohol use disorder. Addiction Biology 2024, 29: e70010. PMID: 39660770, PMCID: PMC11632857, DOI: 10.1111/adb.70010.Peer-Reviewed Original ResearchConceptsAnterior insular cortexAlcohol use disorderRight anterior insular cortexOrbitofrontal cortexUse disorderAlcohol cue-induced cravingStages of alcohol use disorderDorsal anterior cingulate cortexLeft anterior insular cortexNeural responses to stressAlcohol cue-reactivityCue-elicited cravingOFC responsesRight dorsal caudateCue-induced cravingAnterior cingulate cortexVoxel-based analysisResponse to stressPreoccupation/anticipation stageAlcohol cuesCraving assessmentCue-reactivityAmygdala hyperactivationAlcohol cravingCue exposureStability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings
Gao H, Magin Z, Fogelman N, Sinha R, Angarita G, Milivojevic V. Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings. Life 2024, 14: 1483. PMID: 39598281, PMCID: PMC11595496, DOI: 10.3390/life14111483.Peer-Reviewed Original ResearchCocaine use disorderSubstance use disordersUse disorderPregnenolone levelsTreatment of cocaine use disorderReduce alcohol cravingTreatment-seeking individualsAssociated across timeAdministration of pregnenoloneEight-week trialSignificant main effectAlcohol cravingPregnenolone administrationNegative health risksDouble-blind clinical trialMain effectPilot findingsLevels of pregnenoloneChronic dosingStudy medication doseMedication dosesDisordersCocainePilot studyStress biologyS143 Traumatic Events, Chronic Pain, and Multiple Substance Use in Women With Poly-Substance Use Disorder
Fogelman N, Tate M, Wemm S, Vacey E, Bera S, Hermes G, Swain J, Fox H, Sinha R. S143 Traumatic Events, Chronic Pain, and Multiple Substance Use in Women With Poly-Substance Use Disorder. Drug And Alcohol Dependence 2024, 260: 110254. DOI: 10.1016/j.drugalcdep.2023.110254.Peer-Reviewed Original ResearchEvidence that personalized racial stress procedures elicit a stress response and increases alcohol craving among Black adults with alcohol use disorder: A laboratory pilot study
Haeny A, Schick M, McKenley C, Chowdhary A, Bellamy C, O'Malley S, Sinha R. Evidence that personalized racial stress procedures elicit a stress response and increases alcohol craving among Black adults with alcohol use disorder: A laboratory pilot study. Drug And Alcohol Dependence 2024, 260: 111312. PMID: 38749311, DOI: 10.1016/j.drugalcdep.2024.111312.Peer-Reviewed Original ResearchAlcohol use disorderAlcohol cravingIncreased alcohol cravingUse disorderRacial stressEmotional responsesImpact of racial stressBlack adultsExposure to stressStress scriptsImagery procedureExposure sessionsCravingPersonal eventsStress procedureNegative emotionsNeutral conditionsPositive emotionsIdentity explorationStress responseExploratory analysisPhysiological responsesSessionsEmotionsAlcohol
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