2025
Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder
Gao H, Sinha R, Wemm S, Milivojevic V. Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder. Alcohol Clinical And Experimental Research 2025, 49: 619-628. PMID: 39779217, PMCID: PMC11928267, DOI: 10.1111/acer.15529.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment-seeking individualsAlcohol cuesAlcohol cravingResponse to stressPregnenolone groupUse disorderResponse to alcohol cuesGroup x condition interactionHigher alcohol cravingLinear mixed-effects modelsHeart rate variabilityHeart rate variability indicesAutonomic nervous system dysregulationChronic alcohol consumptionRandomized to placeboAutonomic nervous system responsesNervous system dysregulationCravingAlcohol's impactCondition interactionAssociated with autonomic nervous system dysregulationNervous system responsesAutonomic responsesEnhanced autonomic function
2024
Neural responses to stress and alcohol cues in individuals with pain with and without alcohol use disorder
Radoman M, McGowan C, Heilner E, Lacadie C, Sinha R. Neural responses to stress and alcohol cues in individuals with pain with and without alcohol use disorder. Addiction Biology 2024, 29: e70010. PMID: 39660770, PMCID: PMC11632857, DOI: 10.1111/adb.70010.Peer-Reviewed Original ResearchConceptsAnterior insular cortexAlcohol use disorderRight anterior insular cortexOrbitofrontal cortexUse disorderAlcohol cue-induced cravingStages of alcohol use disorderDorsal anterior cingulate cortexLeft anterior insular cortexNeural responses to stressAlcohol cue-reactivityCue-elicited cravingOFC responsesRight dorsal caudateCue-induced cravingAnterior cingulate cortexVoxel-based analysisResponse to stressPreoccupation/anticipation stageAlcohol cuesCraving assessmentCue-reactivityAmygdala hyperactivationAlcohol cravingCue exposure
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