A Branched-Chain Amino Acid-Related Metabolic Signature Characterizes Obese Adolescents with Non-Alcoholic Fatty Liver Disease
Goffredo M, Santoro N, Tricò D, Giannini C, D’Adamo E, Zhao H, Peng G, Yu X, Lam TT, Pierpont B, Caprio S, Herzog RI. A Branched-Chain Amino Acid-Related Metabolic Signature Characterizes Obese Adolescents with Non-Alcoholic Fatty Liver Disease. Nutrients 2017, 9: 642. PMID: 28640216, PMCID: PMC5537762, DOI: 10.3390/nu9070642.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmino Acids, Branched-ChainBiomarkersChildFemaleGlucose Clamp TechniqueHumansMaleNon-alcoholic Fatty Liver DiseaseObesityConceptsNon-alcoholic fatty liver diseaseMagnetic resonance imagingBranched-chain amino acidsFatty liver diseaseHepatic fat contentObese adolescentsInsulin resistanceLiver diseaseTwo-step hyperinsulinemic-euglycemic clampOral glucose tolerance testSecond magnetic resonance imagingSubset of patientsGlucose tolerance testHyperinsulinemic-euglycemic clampHigher plasma levelsHepatic insulin sensitivityChain amino acidsPlasma levelsTolerance testInsulin sensitivityMetabolomic signaturePlasma metabolitesResonance imagingValine levelsLipid metabolismElevated α-Hydroxybutyrate and Branched-Chain Amino Acid Levels Predict Deterioration of Glycemic Control in Adolescents
Tricò D, Prinsen H, Giannini C, de Graaf R, Juchem C, Li F, Caprio S, Santoro N, Herzog RI. Elevated α-Hydroxybutyrate and Branched-Chain Amino Acid Levels Predict Deterioration of Glycemic Control in Adolescents. The Journal Of Clinical Endocrinology & Metabolism 2017, 102: 2473-2481. PMID: 28482070, PMCID: PMC5505187, DOI: 10.1210/jc.2017-00475.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmino Acids, Branched-ChainBiomarkersBlood GlucoseChildCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleGlucose Tolerance TestGlycemic IndexHumansHydroxybutyratesInsulin ResistanceLinear ModelsLongitudinal StudiesMaleMultivariate AnalysisObesityPredictive Value of TestsReference ValuesRisk AssessmentConceptsOral glucose tolerance testBranched-chain amino acidsGlycemic controlInsulin resistanceΑ-hydroxybutyrateGlucose toleranceInsulin sensitivityParameters of IRBody mass index z-scoreType 2 diabetes mellitusEarly metabolic featuresChain amino acid levelsTraditional risk factorsPediatric obesity clinicGlucose tolerance testElevated baseline concentrationsIndex z-scoreType 2 diabetesReduced insulin sensitivityDiabetes mellitusObesity clinicNondiabetic adolescentsProgressive worseningDisposition indexGlucose control