2025
Determinants of increased muscle insulin sensitivity of exercise-trained versus sedentary normal weight and overweight individuals
Pesta D, Anadol-Schmitz E, Sarabhai T, Kamp Y, Gancheva S, Trinks N, Zaharia O, Mastrototaro L, Lyu K, Habets I, Kamp-Bruls Y, Dewidar B, Weiss J, Schrauwen-Hinderling V, Zhang D, Gaspar R, Strassburger K, Kupriyanova Y, Al-Hasani H, Szendroedi J, Schrauwen P, Phielix E, Shulman G, Roden M. Determinants of increased muscle insulin sensitivity of exercise-trained versus sedentary normal weight and overweight individuals. Science Advances 2025, 11: eadr8849. PMID: 39742483, PMCID: PMC11691647, DOI: 10.1126/sciadv.adr8849.Peer-Reviewed Original ResearchConceptsOverweight-to-obeseNormal weightEndurance-trained humansMuscle mitochondrial contentAthlete's paradoxTrained athletesExercise-trainedOverweight individualsAthletesObesity subtypesObservational studyIntramyocellular triglyceride accumulationInsulin sensitivityHigher insulin sensitivityMitochondrial contentIncreased insulin sensitivityMuscleFemale individualsIndividualsInsulin resistanceObesityMitochondrial partitioningIncreased calpainNPKC activityProtein kinase C
2022
Aging reduces ABHD5 protein content in the adipose tissue of mice: The reversal effect of exercise
BrĂcola R, Cordeiro A, Crisol B, Braga R, de Melo D, Rocha M, Gaspar R, Nakandakari S, Silva V, Anaruma C, Katashima C, Canciglieri R, Munõz V, Pavan I, Pinto A, Simabuco F, da Silva A, Moura L, Pauli J, Cintra D, Ropelle E. Aging reduces ABHD5 protein content in the adipose tissue of mice: The reversal effect of exercise. Cell Biochemistry And Function 2022, 41: 128-137. PMID: 36515301, DOI: 10.1002/cbf.3770.Peer-Reviewed Original ResearchConceptsAged miceAdipose tissueControl of lipolysisHigh-intensity interval trainingSubcutaneous white adipose tissueExperimental mouse modelAdipose tissue metabolismWhite adipose tissueMessenger RNA levelsInterval trainingMouse modelTissue metabolismLipolytic pathwayMiceRNA levelsProtein levelsScWATTranscriptomic analyzesReversal effectTissueExerciseSignificant hallmarkLipolysisABHD5Lipolytic activity
2019
Lifelong exercise practice and immunosenescence: Master athletes cytokine response to acute exercise
Minuzzi L, Chupel M, Rama L, Rosado F, Muñoz V, Gaspar R, Kuga G, Furtado G, Pauli J, Teixeira A. Lifelong exercise practice and immunosenescence: Master athletes cytokine response to acute exercise. Cytokine 2019, 115: 1-7. PMID: 30616033, DOI: 10.1016/j.cyto.2018.12.006.Peer-Reviewed Original ResearchConceptsMiddle-aged groupAnti-inflammatory cytokinesMaster athletesAcute exerciseIL-1βIL-4IL-10 levelsAcute exercise effectsMiddle age groupIL-17IL-10IL-1raMaximal incremental testIL-6IL-8Mean VOExercise effectsBlood samplesCycle ergometerExercise practiceAthlete groupCytokinesYounger groupYoung adultsIncremental test
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