2022
Loco-regional radiosensitizing nanoparticles-in-gel augments head and neck cancer chemoradiotherapy
Bhardwaj P, Gota V, Vishwakarma K, Pai V, Chaudhari P, Mohanty B, Thorat R, Yadav S, Gurjar M, Goda JS, Banerjee R. Loco-regional radiosensitizing nanoparticles-in-gel augments head and neck cancer chemoradiotherapy. Journal Of Controlled Release 2022, 343: 288-302. PMID: 35101477, DOI: 10.1016/j.jconrel.2022.01.040.Peer-Reviewed Original Research
2021
Ultrasound augments on-demand breast tumor radiosensitization and apoptosis through a tri-responsive combinatorial delivery theranostic platform
Bhardwaj P, Goda JS, Pai V, Chaudhari P, Mohanty B, Pai T, Vishwakarma K, Thorat R, Wadasadawala T, Banerjee R. Ultrasound augments on-demand breast tumor radiosensitization and apoptosis through a tri-responsive combinatorial delivery theranostic platform. Nanoscale 2021, 13: 17077-17092. PMID: 34622906, DOI: 10.1039/d1nr04211d.Peer-Reviewed Original ResearchConceptsTriple-negative breast cancerBreast cancerAdvanced triple-negative breast cancerPathological response rateCombination of paclitaxelTumor microvessel densityNOD-SCID micePET-CT imagingDose-dependent systemic toxicityCell proliferation markersChemoradiotherapeutic efficacyClinical radiosensitizerNeoadjuvant chemotherapyNeoadjuvant chemoradiotherapyTNBC xenograftsAggressive tumorsCombinatorial regimenConcomitant useMouse survivalMicrovessel densityPathological responseClinical utilitySpatio-temporal deliveryResponse rateSolid tumorsImmunomodulatory nanosystems for treating inflammatory diseases
Ahamad N, Kar A, Mehta S, Dewani M, Ravichandran V, Bhardwaj P, Sharma S, Banerjee R. Immunomodulatory nanosystems for treating inflammatory diseases. Biomaterials 2021, 274: 120875. PMID: 34010755, DOI: 10.1016/j.biomaterials.2021.120875.Peer-Reviewed Original ResearchConceptsHyperactive immune cellsInflammatory diseasesImmune cellsInflammatory bowel diseaseShort-term reliefMechanism of actionCytokine neutralizationStandard therapyT-regsBowel diseaseImmunosuppressive agentsChronic inflammationCytokine productionImmunomodulatory actionsMyocardial infarctionPulmonary disordersMacrophage polarizationInflamed sitesTherapeutic advantageCellular infiltrationLymphatic drainageImmune systemCentral manifestationsSevere burdenDisease
2020
Advancements in prophylactic and therapeutic nanovaccines
Bhardwaj P, Bhatia E, Sharma S, Ahamad N, Banerjee R. Advancements in prophylactic and therapeutic nanovaccines. Acta Biomaterialia 2020, 108: 1-21. PMID: 32268235, PMCID: PMC7163188, DOI: 10.1016/j.actbio.2020.03.020.Peer-Reviewed Original ResearchConceptsImmune responseConventional vaccinesSuitable immune responsePathological conditionsAntibody-mediated immunityImmune system activationStrong immune responseNon-infectious diseasesHigh antigen loadingBooster dosesLymph nodesImmunodeficiency syndromeImmune activationTreatment of cancerMultiple dosesEnhanced immunogenicityAntigen presentationForeign antigensAntigen loadingPatient complianceNovel nanovaccinesSystem activationImmune systemVaccine developmentTherapeutic potential
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