2006
DNA damage and mismatch repair pathway in lung ischemia and reperfusion injury
Bonde P, Gao D, Chen L, Moreno-Vinasco L, Jacobson J, Garcia J, Wei C. DNA damage and mismatch repair pathway in lung ischemia and reperfusion injury. Journal Of Cardiothoracic-Renal Research 2006, 1: 147-152. DOI: 10.1016/j.jccr.2006.05.007.Peer-Reviewed Original ResearchLung ischemiaLung transplantationReperfusion groupReperfusion injuryWestern blotDNA mismatch repair pathwayAdult Sprague-Dawley ratsMismatch repair pathwaySprague-Dawley ratsModel of ischemiaAttractive therapeutic interventionCaspase-3 immunohistochemistryDNA damageCaspase-3 levelsDawley ratsLung tissueOxidative DNA damageReperfusionDNA repair enzymeIschemiaTherapeutic interventionsImmunohistochemistryRepair pathwaysProtein levelsTransplantation
2005
56 ATTENUATION OF RODENT LUNG ISCHEMIA/REPERFUSION INJURY BY SPHINGOSINE 1-PHOSPHATE
Moreno-Vinasco L, Bonde P, Jacobson J, Garcia J. 56 ATTENUATION OF RODENT LUNG ISCHEMIA/REPERFUSION INJURY BY SPHINGOSINE 1-PHOSPHATE. Journal Of Investigative Medicine 2005, 53: s366. DOI: 10.2310/6650.2005.00206.55.Peer-Reviewed Original ResearchIschemia/reperfusion injuryR injuryMyeloperoxidase activityLung transplantationReperfusion injuryVascular permeabilityAlbumin concentrationLung ischemia/reperfusion injuryLung tissue myeloperoxidase activityBronchoalveolar lavage cell countsLavage cell countsLung preservation techniquesPulmonary artery ligationR lung injuryTissue myeloperoxidase activityTime of reperfusionPeriod of reperfusionLung vascular permeabilityPotential therapeutic roleSprague-Dawley ratsImproved patient outcomesNovel therapeutic interventionsProfound clinical implicationsAlveolar damageDonor lungs
2004
Inhibition of the EGFR and hedgehog signaling pathways demonstrate potent growth inhibition in an animal model of esophageal carcinogenesis
Sui G, Bonde P, Dhara S, Marti G, Freguson M, Wang J, Jaffee E, Duncan M, Montgomery E, Maitra A, Harmon J. Inhibition of the EGFR and hedgehog signaling pathways demonstrate potent growth inhibition in an animal model of esophageal carcinogenesis. Journal Of Surgical Research 2004, 121: 278-279. DOI: 10.1016/j.jss.2004.07.040.Peer-Reviewed Original ResearchEpidermal growth factor receptorSignificant growth inhibitionEsophageal carcinogenesisCell linesVivo growthGrowth inhibitionSquamous cell carcinomaSprague-Dawley ratsReliable preclinical modelsHh pathway antagonistsImportant oncogenic pathwaysBilious refluxMock-treated cellsGrowth factor receptorAdenosquamous cancerCell carcinomaEsophageal cancerSD ratsPreclinical modelsSubcutaneous xenograftsAthymic miceSmall molecule inhibitorsAnimal modelsPotent growth inhibitionExperimental therapeutics