2024
Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia
Suthaharan P, Thompson S, Rossi-Goldthorpe R, Rudebeck P, Walton M, Chakraborty S, Noonan M, Costa V, Murray E, Mathys C, Groman S, Mitchell A, Taylor J, Corlett P, Chang S. Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Reports 2024, 43: 114355. PMID: 38870010, PMCID: PMC11231991, DOI: 10.1016/j.celrep.2024.114355.Peer-Reviewed Original ResearchOrbitofrontal cortexMediodorsal thalamusReward learning rateAssociated with paranoiaExcitotoxic lesionsBrain regionsUnoperated monkeysAction selectionAdaptive behaviorParanoiaBelief updatingMDmcMeaningful changeCortexThalamusBeliefsLearning rateRobust to variabilityCompare performanceRewardBehaviorBrainMonkeysAction policiesPerception
2023
Using dimensionality-reduction techniques to understand the organization of psychotic symptoms in persistent psychotic illness and first episode psychosis
Fleming L, Lemonde A, Benrimoh D, Gold J, Taylor J, Malla A, Joober R, Iyer S, Lepage M, Shah J, Corlett P. Using dimensionality-reduction techniques to understand the organization of psychotic symptoms in persistent psychotic illness and first episode psychosis. Scientific Reports 2023, 13: 4841. PMID: 36964175, PMCID: PMC10039017, DOI: 10.1038/s41598-023-31909-w.Peer-Reviewed Original ResearchConceptsHallucinations/delusionsFirst-episode psychosisFirst-episode psychosis participantsEarly intervention programsPathophysiological mechanismsUnderlying pathophysiologyEpisode psychosisPsychotic illnessPsychotic symptomsPsychotic disordersSchizoaffective disorderAuditory hallucinationsPositive symptomsHallucination severityNegative symptomsSymptomsDisorganization symptomsIntervention programsHallucinationsIllnessPsychosis participantsPsychosisDelusionsDisordersParticipants
2020
Drugs That Induce Psychotic Symptoms Acutely Impair Mediated Learning in Rats
Fleming L, Doheny D, Robinette M, Corlett P, Taylor J. Drugs That Induce Psychotic Symptoms Acutely Impair Mediated Learning in Rats. Biological Psychiatry 2020, 87: s164. DOI: 10.1016/j.biopsych.2020.02.435.Peer-Reviewed Original Research
2013
Chapter 13 The Translational Potential of Memory Reconsolidation
Corlett P, Taylor J. Chapter 13 The Translational Potential of Memory Reconsolidation. 2013, 273-292. DOI: 10.1016/b978-0-12-386892-3.00013-5.Peer-Reviewed Original ResearchPost-traumatic stress disorderMemory labileMemory reconsolidationMemory processingLabile stateStress disorderMemory erasureDrug addictionPast experienceReconsolidationSerious mental illnessCurrent processingMemoryMental illnessProcessingAddictionEthical implicationsChapter 13PsychosisDisordersImplicationsIllnessExperience
2009
Why Do Delusions Persist?
Corlett PR, Krystal JH, Taylor JR, Fletcher PC. Why Do Delusions Persist? Frontiers In Human Neuroscience 2009, 3: 12. PMID: 19636384, PMCID: PMC2713737, DOI: 10.3389/neuro.09.012.2009.Peer-Reviewed Original Research
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