2025
A generalized reward processing deficit pathway to negative symptoms across diagnostic boundaries
Spilka M, Millman Z, Waltz J, Walker E, Levin J, Powers A, Corlett P, Schiffman J, Gold J, Silverstein S, Ellman L, Mittal V, Woods S, Zinbarg R, Strauss G. A generalized reward processing deficit pathway to negative symptoms across diagnostic boundaries. Psychological Medicine 2025, 55: e6. PMID: 39901872, DOI: 10.1017/s003329172400326x.Peer-Reviewed Original ResearchConceptsNegative symptomsDiagnostic boundariesPsychiatric diagnosisTransdiagnostic sample of youthProcessing profilesEffort-cost computationsPositive valence systemsElevated negative symptomsHelp-seeking participantsClinical high riskClinical group membershipSample of youthHedonic reactivityTransdiagnostic sampleCHR criteriaNeurobiological mechanismsPsychosis riskSubgroup of participantsBehavioral tasksClinical interviewPsychiatric disordersClinical participantsValence systemsGroup membershipDiagnostic classificationRevisiting the Defeatist Performance Belief Scale in Adults With Schizophrenia and Youth at Clinical High-Risk for Psychosis: A Comprehensive Psychometric Analysis
Luther L, Ahmed A, Grant P, Granholm E, Gold J, Williams T, Pratt D, Holden J, Walker E, Arnold L, Ellman L, Mittal V, Zinbarg R, Silverstein S, Corlett P, Powers A, Woods S, Waltz J, Schiffman J, Strauss G. Revisiting the Defeatist Performance Belief Scale in Adults With Schizophrenia and Youth at Clinical High-Risk for Psychosis: A Comprehensive Psychometric Analysis. Schizophrenia Bulletin 2025, sbae220. PMID: 39749462, DOI: 10.1093/schbul/sbae220.Peer-Reviewed Original ResearchDefeatist performance beliefsSchizophrenia spectrum groupClinical high riskNegative symptomsFactor structureCognitive model of negative symptomsMechanisms of negative symptomsModel of negative symptomsNegative symptom improvementNegative symptoms treatmentPhase of psychosisFactor analysisComprehensive psychometric analysisConfirmatory factor analysisExploratory factor analysisPositive symptomsCHR samplesPerformance beliefsMeasurement invarianceDiscriminant validityConvergent validityPsychometric propertiesCognitive modelUnidimensional modelBeliefs Scale
2024
11. Role of Prediction Errors in the Relationship Between Ethnoracial Discrimination and Delusions
Huque Z, O'Brien K, Rossi-Goldthorpe R, Kenney J, Mittal V, Strauss G, Walker E, Schiffman J, Woods S, Powers A, Silverstein S, Waltz J, Gold J, Corlett P, Ellman L. 11. Role of Prediction Errors in the Relationship Between Ethnoracial Discrimination and Delusions. Biological Psychiatry 2024, 95: s78-s79. DOI: 10.1016/j.biopsych.2024.02.189.Peer-Reviewed Original ResearchDifferent learning aberrations relate to delusion-like beliefs with different contents
Rossi-Goldthorpe R, Silverstein S, Gold J, Schiffman J, Waltz J, Williams T, Powers A, Woods S, Zinbarg R, Mittal V, Ellman L, Strauss G, Walker E, Levin J, Castiello S, Kenney J, Corlett P. Different learning aberrations relate to delusion-like beliefs with different contents. Brain 2024, 147: 2854-2866. PMID: 38637303, PMCID: PMC11292907, DOI: 10.1093/brain/awae122.Peer-Reviewed Original ResearchProbabilistic reversal learningDelusion-like beliefsProbabilistic reversal learning taskBlocked cueControl cuesBelief convictionBlock taskClinical high-risk statusKamin blocking taskSymptom-specific effectsPrediction error accountLevels of paranoiaIntact learningAberrant learningKamin blockingParanoid individualsPersecutory delusionsCue presentationReversal learningPredicting psychosisCognitive tasksBehavioral resultsDecreased learningDelusionsParanoia
2023
Self-reported Gesture Interpretation and Performance Deficits in Individuals at Clinical High Risk for Psychosis
Karp E, Williams T, Ellman L, Strauss G, Walker E, Corlett P, Woods S, Powers A, Gold J, Schiffman J, Waltz J, Silverstein S, Mittal V. Self-reported Gesture Interpretation and Performance Deficits in Individuals at Clinical High Risk for Psychosis. Schizophrenia Bulletin 2023, 49: 746-755. PMID: 36939086, PMCID: PMC10154698, DOI: 10.1093/schbul/sbac197.Peer-Reviewed Original ResearchConceptsClinical high riskGesture deficitsInternalizing disordersCHR groupGesture interpretationLower verbal learningViable assessment toolVerbal learningNeurocognitive tasksGeneral intelligencePerformance deficitsNonverbal behaviorProcessing speedCHR participantsSimilar deficitsGreater deficitsHigh riskClinical InterviewFull psychotic disorderDeficitsSpecific subdomainsSRGPPsychotic disordersPsychosisGesturesThe reliability and validity of the revised Green et al. paranoid thoughts scale in individuals at clinical high‐risk for psychosis
Williams T, Walker E, Strauss G, Woods S, Powers A, Corlett P, Schiffman J, Waltz J, Gold J, Silverstein S, Ellman L, Zinbarg R, Mittal V. The reliability and validity of the revised Green et al. paranoid thoughts scale in individuals at clinical high‐risk for psychosis. Acta Psychiatrica Scandinavica 2023, 147: 623-633. PMID: 36905387, PMCID: PMC10463775, DOI: 10.1111/acps.13545.Peer-Reviewed Original ResearchConceptsCHR individualsClinical controlFull psychosisHealthy controlsGeneral populationPsychosis symptomsCHR participantsPoor social functioningGreen Paranoid Thoughts ScalePsychosisGroup differencesSocial functioningConfirmatory factor analysisParanoid Thoughts ScaleInterview measuresSeverity continuumTwo-factor structureCritical populationSelf-report measuresPresent studyDiscriminant validityPsychometric indicesParanoid thoughtsIndividualsParticipantsLearning to Discern the Voices of Gods, Spirits, Tulpas, and the Dead
Luhrmann T, Alderson-Day B, Chen A, Corlett P, Deeley Q, Dupuis D, Lifshitz M, Moseley P, Peters E, Powell A, Powers A. Learning to Discern the Voices of Gods, Spirits, Tulpas, and the Dead. Schizophrenia Bulletin 2023, 49: s3-s12. PMID: 36840538, PMCID: PMC9959996, DOI: 10.1093/schbul/sbac005.Peer-Reviewed Original ResearchComparing a Computerized Digit Symbol Test to a Pen-and-Paper Classic
Pratt D, Luther L, Kinney K, Osborne K, Corlett P, Powers A, Woods S, Gold J, Schiffman J, Ellman L, Strauss G, Walker E, Zinbarg R, Waltz J, Silverstein S, Mittal V. Comparing a Computerized Digit Symbol Test to a Pen-and-Paper Classic. Schizophrenia Bulletin Open 2023, 4: sgad027. PMID: 37868160, PMCID: PMC10590153, DOI: 10.1093/schizbullopen/sgad027.Peer-Reviewed Original ResearchClinical high riskCHR individualsFinger-tapping taskMotor ability measuresDigit symbol testCHR stateHealthy controlsHigh riskClinical InterviewPersistent subgroupSymbol testPersistent groupImpairmentPaper versionMotor abilitiesTask performance differencesComputerized versionSimilar degreeEffect sizeMeasures impairmentPsychosisCoding TestRemote assessmentSubgroupsDigit-symbol task
2021
Magnetic Resonance Spectroscopy Investigation of Conditioned Auditory Percepts
Michaels T, Chen C, Hancock R, Corlett P, Powers A. Magnetic Resonance Spectroscopy Investigation of Conditioned Auditory Percepts. Biological Psychiatry 2021, 89: s154. DOI: 10.1016/j.biopsych.2021.02.395.Peer-Reviewed Original Research
2019
29.1 COMPUTATIONAL MODELING OF PERCEPTION AND BEHAVIOR REVEALS HIDDEN INSIGHTS INTO MECHANISMS OF PSYCHOTIC SYMPTOMS
Powers A, Mathys C, Corlett P. 29.1 COMPUTATIONAL MODELING OF PERCEPTION AND BEHAVIOR REVEALS HIDDEN INSIGHTS INTO MECHANISMS OF PSYCHOTIC SYMPTOMS. Schizophrenia Bulletin 2019, 45: s136-s136. PMCID: PMC6455883, DOI: 10.1093/schbul/sbz022.117.Peer-Reviewed Original Research
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