2001
Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers
Sant'Angelo D, Cresswell P, Janeway C, Denzin L. Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 6824-6829. PMID: 11381132, PMCID: PMC34437, DOI: 10.1073/pnas.121179998.Peer-Reviewed Original ResearchConceptsAllelic exclusionTCR heterodimerTCR proteinsCell surface expressionTCR lociT cellsCell surfaceFurther recombinationProteinAlpha chainBeta chainHeterodimersSurface expressionTransgenic miceTCR transgenic miceCellsAdditional mechanismExpressionTCR clonalityAssembly processGenesSecond TCRLociRNATCR
1998
Intracellular formation and cell surface expression of a complex of an intact lysosomal protein and MHC class II molecules.
Arunachalam B, Pan M, Cresswell P. Intracellular formation and cell surface expression of a complex of an intact lysosomal protein and MHC class II molecules. The Journal Of Immunology 1998, 160: 5797-806. PMID: 9637490, DOI: 10.4049/jimmunol.160.12.5797.Peer-Reviewed Original ResearchAllelesAnimalsCell Transformation, ViralElectrophoresis, Polyacrylamide GelFlow CytometryFluorescent Antibody Technique, IndirectHerpesvirus 4, HumanHistocompatibility Antigens Class IIHLA-D AntigensHLA-DR AntigensLysosomesMiceOxidoreductasesOxidoreductases Acting on Sulfur Group DonorsProteinsRabbitsSodium Dodecyl SulfateSurface PropertiesHLA-B27–Restricted Antigen Presentation in the Absence of Tapasin Reveals Polymorphism in Mechanisms of HLA Class I Peptide Loading
Peh C, Burrows S, Barnden M, Khanna R, Cresswell P, Moss D, McCluskey J. HLA-B27–Restricted Antigen Presentation in the Absence of Tapasin Reveals Polymorphism in Mechanisms of HLA Class I Peptide Loading. Immunity 1998, 8: 531-542. PMID: 9620674, DOI: 10.1016/s1074-7613(00)80558-0.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAnimalsAntigen PresentationAntiportersATP Binding Cassette Transporter, Subfamily B, Member 2ATP Binding Cassette Transporter, Subfamily B, Member 3ATP-Binding Cassette TransportersBeta 2-MicroglobulinCells, CulturedDisease SusceptibilityHLA-B AntigensHLA-B27 AntigenHLA-B44 AntigenHumansImmunoglobulinsMembrane Transport ProteinsMicePolymorphism, GeneticProtein BindingSurface PropertiesTransfection
1995
Different MHC class I alleles compete for presentation of overlapping viral epitopes
Tussey L, Rowland-Jones S, Zheng T, Androlewicz M, Cresswell P, Frelinger J, McMichael A. Different MHC class I alleles compete for presentation of overlapping viral epitopes. Immunity 1995, 3: 65-77. PMID: 7542549, DOI: 10.1016/1074-7613(95)90159-0.Peer-Reviewed Original Research
1994
In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides
Avva R, Cresswell P. In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides. Immunity 1994, 1: 763-774. PMID: 7895165, DOI: 10.1016/s1074-7613(94)80018-9.Peer-Reviewed Original ResearchConceptsHLA-DM expressionDR alpha beta dimersHLA-DR moleculesCLIP dissociationClass II moleculesHLA-DR complexInvariant chain peptideII-peptide complexesPrimary aliphatic aminesResidual fragmentsChain-derived peptideClass IIHLA-DMAliphatic aminesCarboxylic acidsSuch complexesUnbranched hydrocarbonsAlpha beta dimersChain peptideInvariant chain-derived peptidesComplexesVivoCLIP complexBeta dimersDissociation
1992
HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides
Wei M, Cresswell P. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides. Nature 1992, 356: 443-446. PMID: 1557127, DOI: 10.1038/356443a0.Peer-Reviewed Original Research
1976
HLA‐B specificities and w4, w6 specificities are on the same polypeptide
Ayres J, Cresswell P. HLA‐B specificities and w4, w6 specificities are on the same polypeptide. European Journal Of Immunology 1976, 6: 794-799. PMID: 63373, DOI: 10.1002/eji.1830061108.Peer-Reviewed Original ResearchConceptsHLA-B7HLA-B12HLA-B determinantsAntigenic determinantsDistinct antigenic determinantsDifferent antigenic determinantsHLA-B specificitiesHLA-B locusHLA-B locus productsSequential immunoprecipitation experimentsLymphoblastoid cell linesAntigen poolCell linesLocus productsHunter reagentSpecificityImmunoprecipitation experimentsPapain digestionDeterminantsDiallelic systemAlloantiseraSame polypeptide