2024
Microscopic phage adsorption assay: High-throughput quantification of virus particle attachment to host bacterial cells
Antani J, Ward T, Emonet T, Turner P. Microscopic phage adsorption assay: High-throughput quantification of virus particle attachment to host bacterial cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2410905121. PMID: 39700139, PMCID: PMC11670125, DOI: 10.1073/pnas.2410905121.Peer-Reviewed Original ResearchConceptsBacterial cellsViruses of bacteriaHost bacterial cellsTarget bacterial strainsEnumeration of bacteriaPhage biologyPhage attachmentHigh-throughput quantificationPhage libraryBacterial pathogensHigh-throughput screeningPhageBacterial strainsSingle-virusVirus particlesIndividual virus particlesFluorescence microscopyBacteriaEarth's biosphereParticle trackingCellsLow throughputBacteriumRate constantsPathogens
2023
Developing Phage Therapy That Overcomes the Evolution of Bacterial Resistance
OromĂ-Bosch A, Antani J, Turner P. Developing Phage Therapy That Overcomes the Evolution of Bacterial Resistance. Annual Review Of Virology 2023, 10: 503-524. PMID: 37268007, DOI: 10.1146/annurev-virology-012423-110530.Peer-Reviewed Original ResearchConceptsPhage therapyPhage resistanceBacterial resistanceEvolution of phage resistancePhage-resistant bacteriaEvolution of bacterial resistanceBacteria-specific virusesTreatment of intractable infectionsAlternative antimicrobial strategiesPersonalized medicine treatmentsPhage strategyClinically favorable outcomesBacterial pathogensBacterial populationsPhageTarget bacteriaAntibiotic resistanceAntimicrobial strategiesIntractable infectionsWaning efficacyFavorable outcomeBacterial infectionsBacteriaTherapyPatient treatment
2016
Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa
Chan BK, Sistrom M, Wertz JE, Kortright KE, Narayan D, Turner PE. Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa. Scientific Reports 2016, 6: 26717. PMID: 27225966, PMCID: PMC4880932, DOI: 10.1038/srep26717.Peer-Reviewed Original ResearchConceptsMDR P. aeruginosaMDR Pseudomonas aeruginosaEfflux pump mechanismAntibiotic-resistant infectionsResistant bacterial infectionsPseudomonas aeruginosaReceptor-binding siteMDR bacteriaTherapeutic interventionsResistant infectionsBacterial infectionsReduced pathogenesisAntibiotic sensitivityAntibiotic classesPhage therapyCurrent antibioticsNovel antibacterial strategiesTherapyP. aeruginosaInfectionBacterial pathogensBacterial resistanceLytic bacteriophagesAntibioticsTraditional antibiotics
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