2019
Spatially-variant image-based modeling of PSF deformations with application to a limited angle geometry from a dual-panel breast-PET imager
Gravel P, Surti S, Krishnamoorthy S, Karp J, Matej S. Spatially-variant image-based modeling of PSF deformations with application to a limited angle geometry from a dual-panel breast-PET imager. Physics In Medicine And Biology 2019, 64: 225015. PMID: 31569078, PMCID: PMC7236960, DOI: 10.1088/1361-6560/ab4914.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBreastBreast NeoplasmsComputer SimulationFemaleHumansImage Processing, Computer-AssistedModels, StatisticalPhantoms, ImagingPositron-Emission TomographyReproducibility of ResultsTomography, X-Ray ComputedConceptsRealistic breast modelResolution modelingConsiderable deformationImage-based modelingDeformationSystem configurationPoint spread functionLimited angle geometryDirect image reconstructionBreast modelFlight methodRMSE valuesAngle geometryConsistent performanceOverall errorPerformanceModelingAccurate lesion locationImage reconstructionConsiderable improvementReconstructed imagesQuantitative performanceDeconvolution methodHigh-count dataLow-count data
2013
Grey matter density and GABAA binding potential show a positive linear relationship across cortical regions
Duncan N, Gravel P, Wiebking C, Reader A, Northoff G. Grey matter density and GABAA binding potential show a positive linear relationship across cortical regions. Neuroscience 2013, 235: 226-231. PMID: 23380503, DOI: 10.1016/j.neuroscience.2012.12.075.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainCerebral CortexFemaleFlumazenilGABA ModulatorsHumansImage Processing, Computer-AssistedLinear ModelsMagnetic Resonance ImagingMalePositron-Emission TomographyRadiopharmaceuticalsReceptors, GABA-AYoung Adult
2012
External awareness and GABA—A multimodal imaging study combining fMRI and [18F]flumazenil‐PET
Wiebking C, Duncan N, Qin P, Hayes D, Lyttelton O, Gravel P, Verhaeghe J, Kostikov A, Schirrmacher R, Reader A, Bajbouj M, Northoff G. External awareness and GABA—A multimodal imaging study combining fMRI and [18F]flumazenil‐PET. Human Brain Mapping 2012, 35: 173-184. PMID: 22996793, PMCID: PMC6869063, DOI: 10.1002/hbm.22166.Peer-Reviewed Original ResearchConceptsNeuronal activity changesInhibitory neurotransmitter GABANegative BOLD responseFunctional magnetic resonance imaging paradigmCortical midline regionsSame healthy subjectsGABAA receptorsHealthy subjectsNeurotransmitter GABAPsychiatric disordersBiochemical mechanismsPET imagingExtrinsic systemMidline regionBOLD responseExternal awarenessNeuronal networksUnderlying neuronal networksImaging paradigmGABAActivity changesStimulus typeSame paradigmAwarenessPrecuneus
2010
Task-oriented quantitative image reconstruction in emission tomography for single- and multi-subject studies
Verhaeghe J, Gravel P, Reader A. Task-oriented quantitative image reconstruction in emission tomography for single- and multi-subject studies. Physics In Medicine And Biology 2010, 55: 7263-7285. PMID: 21081825, DOI: 10.1088/0031-9155/55/23/006.Peer-Reviewed Original ResearchWhere in-vivo imaging meets cytoarchitectonics: The relationship between cortical thickness and neuronal density measured with high-resolution [18F]flumazenil-PET
la Fougère C, Grant S, Kostikov A, Schirrmacher R, Gravel P, Schipper H, Reader A, Evans A, Thiel A. Where in-vivo imaging meets cytoarchitectonics: The relationship between cortical thickness and neuronal density measured with high-resolution [18F]flumazenil-PET. NeuroImage 2010, 56: 951-960. PMID: 21073964, DOI: 10.1016/j.neuroimage.2010.11.015.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlgorithmsBrain MappingCerebral CortexData Interpretation, StatisticalFemaleFlumazenilGABA ModulatorsHumansImage Processing, Computer-AssistedIndividualityIsotope LabelingMagnetic Resonance ImagingMaleMiddle AgedNeuronsPositron-Emission TomographyRadiopharmaceuticalsReceptors, GABARegression AnalysisConceptsNeuronal densityCortical thicknessAxo-dendritic synapsesSensory-motor cortexHuman brain areasDifferent cytoarchitectonic areasFlumazenil PETMotor cortexApparent cortical thicknessCortical thickness mapsHealthy subjectsBrain areasMorphometry studyCytoarchitectonic areasCortical morphologyCortical regionsCortical distributionVivo studiesFMZReceptor complexPartial volume correctionCytoarchitectonicsSensitive toolDifferential relationshipsSubsetMotion compensation for fully 4D PET reconstruction using PET superset data
Verhaeghe J, Gravel P, Mio R, Fukasawa R, Rosa-Neto P, Soucy J, Thompson C, Reader A. Motion compensation for fully 4D PET reconstruction using PET superset data. Physics In Medicine And Biology 2010, 55: 4063-4082. PMID: 20601774, DOI: 10.1088/0031-9155/55/14/008.Peer-Reviewed Original ResearchConceptsSubject head motionPET reconstructionPET image reconstructionHead motionImage reconstruction algorithmMotion compensation methodImage framesOptical tracking systemMotion compensationList-mode eventsImage reconstructionTracking systemReconstruction algorithmSingle instanceMotion compensation strategyAlgorithmMultiple time framesReconstruction methodNormalization schemeImportant issuePET dataBasis functionsDynamic PET imagingHead movementsParametric images
2008
Decreased [18F]MPPF Binding Potential in the Dorsal Raphe Nucleus After a Single Oral Dose of Fluoxetine: A Positron-Emission Tomography Study in Healthy Volunteers
Sibon I, Benkelfat C, Gravel P, Aznavour N, Costes N, Mzengeza S, Booij L, Baker G, Soucy J, Zimmer L, Descarries L. Decreased [18F]MPPF Binding Potential in the Dorsal Raphe Nucleus After a Single Oral Dose of Fluoxetine: A Positron-Emission Tomography Study in Healthy Volunteers. Biological Psychiatry 2008, 63: 1135-1140. PMID: 18191817, DOI: 10.1016/j.biopsych.2007.11.016.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdultAntidepressive Agents, Second-GenerationAutoreceptorsBrainDouble-Blind MethodFluorine RadioisotopesFluoxetineHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMalePiperazinesPositron-Emission TomographyPyridinesRaphe NucleiReceptor, Serotonin, 5-HT1AReference Values
2006
Acute prefrontal cortex TMS in healthy volunteers: Effects on brain 11C-αMtrp trapping
Sibon I, Strafella A, Gravel P, Ko J, Booij L, Soucy J, Leyton M, Diksic M, Benkelfat C. Acute prefrontal cortex TMS in healthy volunteers: Effects on brain 11C-αMtrp trapping. NeuroImage 2006, 34: 1658-1664. PMID: 17188517, DOI: 10.1016/j.neuroimage.2006.08.059.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationLeft dorsolateral prefrontal cortexAcute repetitive transcranial magnetic stimulationLeft occipital cortexHealthy volunteersLimbic areasMajor depressionHigh-frequency repetitive transcranial magnetic stimulationHz repetitive transcranial magnetic stimulationPrefrontal repetitive transcranial magnetic stimulationRight cingulate gyrusSerotonin synthesis capacityTranscranial magnetic stimulationAutonomic measuresLeft parahippocampal gyrusDorsolateral prefrontal cortexMechanism of actionRTMS sessionsBrain uptakeRandomized counterbalanced orderCingulate gyrusRight insulaOccipital cortexMagnetic stimulationParahippocampal gyrus