2019
Spatially-variant image-based modeling of PSF deformations with application to a limited angle geometry from a dual-panel breast-PET imager
Gravel P, Surti S, Krishnamoorthy S, Karp J, Matej S. Spatially-variant image-based modeling of PSF deformations with application to a limited angle geometry from a dual-panel breast-PET imager. Physics In Medicine And Biology 2019, 64: 225015. PMID: 31569078, PMCID: PMC7236960, DOI: 10.1088/1361-6560/ab4914.Peer-Reviewed Original ResearchConceptsRealistic breast modelResolution modelingConsiderable deformationImage-based modelingDeformationSystem configurationPoint spread functionLimited angle geometryDirect image reconstructionBreast modelFlight methodRMSE valuesAngle geometryConsistent performanceOverall errorPerformanceModelingAccurate lesion locationImage reconstructionConsiderable improvementReconstructed imagesQuantitative performanceDeconvolution methodHigh-count dataLow-count data
2015
Direct 4D PET MLEM reconstruction of parametric images using the simplified reference tissue model with the basis function method for [11C]raclopride
Gravel P, Reader A. Direct 4D PET MLEM reconstruction of parametric images using the simplified reference tissue model with the basis function method for [11C]raclopride. Physics In Medicine And Biology 2015, 60: 4533-4549. PMID: 25992999, DOI: 10.1088/0031-9155/60/11/4533.Peer-Reviewed Original Research
2010
Where in-vivo imaging meets cytoarchitectonics: The relationship between cortical thickness and neuronal density measured with high-resolution [18F]flumazenil-PET
la Fougère C, Grant S, Kostikov A, Schirrmacher R, Gravel P, Schipper H, Reader A, Evans A, Thiel A. Where in-vivo imaging meets cytoarchitectonics: The relationship between cortical thickness and neuronal density measured with high-resolution [18F]flumazenil-PET. NeuroImage 2010, 56: 951-960. PMID: 21073964, DOI: 10.1016/j.neuroimage.2010.11.015.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlgorithmsBrain MappingCerebral CortexData Interpretation, StatisticalFemaleFlumazenilGABA ModulatorsHumansImage Processing, Computer-AssistedIndividualityIsotope LabelingMagnetic Resonance ImagingMaleMiddle AgedNeuronsPositron-Emission TomographyRadiopharmaceuticalsReceptors, GABARegression AnalysisConceptsNeuronal densityCortical thicknessAxo-dendritic synapsesSensory-motor cortexHuman brain areasDifferent cytoarchitectonic areasFlumazenil PETMotor cortexApparent cortical thicknessCortical thickness mapsHealthy subjectsBrain areasMorphometry studyCytoarchitectonic areasCortical morphologyCortical regionsCortical distributionVivo studiesFMZReceptor complexPartial volume correctionCytoarchitectonicsSensitive toolDifferential relationshipsSubsetMotion compensation for fully 4D PET reconstruction using PET superset data
Verhaeghe J, Gravel P, Mio R, Fukasawa R, Rosa-Neto P, Soucy J, Thompson C, Reader A. Motion compensation for fully 4D PET reconstruction using PET superset data. Physics In Medicine And Biology 2010, 55: 4063-4082. PMID: 20601774, DOI: 10.1088/0031-9155/55/14/008.Peer-Reviewed Original ResearchConceptsSubject head motionPET reconstructionPET image reconstructionHead motionImage reconstruction algorithmMotion compensation methodImage framesOptical tracking systemMotion compensationList-mode eventsImage reconstructionTracking systemReconstruction algorithmSingle instanceMotion compensation strategyAlgorithmMultiple time framesReconstruction methodNormalization schemeImportant issuePET dataBasis functionsDynamic PET imagingHead movementsParametric images