2025
Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study
Dribin T, Sampson H, Zhang Y, Boyd S, Zhang N, Michelson K, Neuman M, Brousseau D, Mistry R, Freedman S, Aronson P, Bergmann K, Boswell B, Chinta S, Chua W, Cohen A, Cohen J, Daggett A, Davis J, Freeman J, Khanna K, Knoles C, Kwan K, Larsen C, Lee J, Lubell T, Metcalf A, Moake M, Nesiama J, Ngo T, Pulcini C, Russo C, Singh N, Srivastava G, Strutt J, Thapar V, Vander Wyst C, Walsh P, Wolnerman Y, Schnadower D, Academy of Pediatrics P, Kanngiesser A, McGarghan F, Dulchavsky A, Costalez J, DesPain A, Armanious M, Haghnazarian E, Brown-Whitehorn T, Weigert R, Dayan P, Meltzer J, Chowdhury N, Benedetti J, Sinziana C, Handorf A, Ruthford M, Devens M, Mecham C, Holland J, Casas T, Brown J, Panda P, Morrow A, Maready M, Nathani Y, Stevens M, Abraham G, Yen K, Cooper-Sood J, Woolf S. Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study. The Lancet Child & Adolescent Health 2025, 9: 484-496. PMID: 40506197, DOI: 10.1016/s2352-4642(25)00139-7.Peer-Reviewed Original ResearchConceptsElectronic medical recordsEmergency departmentRetrospective cohort studyCohort studyMedical recordsDocumentation of symptomsCardiovascular involvementHealth-care facilitiesEpinephrine doseAcute allergic reactionsNational Institutes of HealthCumulative incidenceNational Center for Advancing Translational SciencesInstitutes of HealthChildren aged 6 monthsClinical ModificationHospital wardsIncidence rateICD-10Observation periodPrimary outcomeAllergic reactionsSecondary to medicationsInitiation to discontinuationKaplan-Meier analysisRisk Factors for Serious Bacterial Infections Among Young Infants With Hypothermia: Protocol for a Multicenter, Retrospective Case-Control Study
Ramgopal S, Aronson P, Lorenz D, Rogers A, Cruz A. Risk Factors for Serious Bacterial Infections Among Young Infants With Hypothermia: Protocol for a Multicenter, Retrospective Case-Control Study. JMIR Research Protocols 2025, 14: e66722. PMID: 40536806, DOI: 10.2196/66722.Peer-Reviewed Original ResearchConceptsEpidemiology of SBIHerpes simplex virusCase-control studyEmergency departmentYoung infantsMultivariable prediction modelRetrospective nested case-control studyBacterial infectionsRetrospective case-control studyManagement of young infantsNested case-control studyUrinary tract infectionOptimal cutoff valueSerious bacterial infectionsSoft tissue infectionsOutcome measuresPediatric Emergency Medicine Collaborative Research CommitteeReceiver operating characteristic curvePediatric emergency departmentOperating characteristics curveUS children's hospitalsMixed effects logistic regressionHSV-positiveBlood culturesPredicting SBIRisk of Bacterial Infections in Febrile Infants 61 to 90 Days Old With Respiratory Viruses.
Aronson P, Mahajan P, Nielsen B, Olsen C, Meeks H, Grundmeier R, Kuppermann N. Risk of Bacterial Infections in Febrile Infants 61 to 90 Days Old With Respiratory Viruses. 2025, 156 PMID: 40506050, DOI: 10.1542/peds.2025-070617.Peer-Reviewed Original ResearchConceptsPrevalence of urinary tract infectionUrinary tract infectionPediatric Emergency Care Applied Research NetworkRespiratory viral testingRespiratory viral infectionsFebrile infantsBacterial meningitisRespiratory virusesSARS-CoV-2Viral testingViral infectionSARS-CoV-2-positive infantsBacterial infectionsRisk of bacterial infectionPrevalence of bacteremiaPrevalence of bacterial infectionRespiratory syncytial virusBlood culturesTract infectionsPositive infantsSyncytial virusNegative infantsBacteremiaMeningitisInfantsInflammatory Markers and Invasive Bacterial Infection in Febrile Infants With Positive Urinalyses.
Ruiz B, Yankova L, McDaniel C, Kerns E, Aronson P. Inflammatory Markers and Invasive Bacterial Infection in Febrile Infants With Positive Urinalyses. 2025, 155 PMID: 40341581, DOI: 10.1542/peds.2025-071109.Peer-Reviewed Original ResearchUrine Dipstick for the Diagnosis of Urinary Tract Infection in Febrile Infants Aged 2 to 6 Months.
Hunt K, Green R, Sartori L, Aronson P, Chamberlain J, Florin T, Michelson K, Monuteaux M, Chaudhari P, Nigrovic L. Urine Dipstick for the Diagnosis of Urinary Tract Infection in Febrile Infants Aged 2 to 6 Months. 2025, 155 PMID: 40122108, DOI: 10.1542/peds.2024-068671.Peer-Reviewed Original ResearchConceptsDiagnosis of urinary tract infectionUrinary tract infectionUrine WBC countUrine dipstickUrine cultureAged 2 to 6Receiver operating characteristicWhite blood cellsTract infectionsColony-forming unitsUrine white blood cellsWBC countCatheterized urine culturePositive urine dipstickInitial treatment decisionsAccurate diagnostic testCross-sectional studyBacterial uropathogensFebrile infantsLaboratory urinalysisTreatment decisionsDiagnostic testsEmergency departmentUrinalysisUrine“He was not listening to hear me”: Parent experiences with communication, inclusion, and marginalization in the pediatric emergency department
Gutman C, McFarlane A, Fernandez R, Lion K, Aronson P, Bylund C, Joseph N, Mecias M, Fisher C. “He was not listening to hear me”: Parent experiences with communication, inclusion, and marginalization in the pediatric emergency department. Academic Emergency Medicine 2025, 32: 632-642. PMID: 39912698, DOI: 10.1111/acem.15091.Peer-Reviewed Original ResearchPatient-centered communicationPediatric emergency departmentEmergency departmentED visitsPublic Health Critical Race PraxisPromote health equityChild's ED visitClinician communication behaviorsHealth care encountersProactive communicationPediatric ED visitsPediatric ED patientsPerspective of parentsEthnic backgroundCritical Race PraxisHealth equityClinician communicationThematic saturationCare encountersMedical encountersThematic analysisExperiences of racismPartnership buildingEmpathic communicationED patients
2024
Natural Language Processing to Identify Infants Aged 90 Days and Younger With Fevers Prior to Presentation.
Aronson P, Kuppermann N, Mahajan P, Nielsen B, Olsen C, Meeks H, Grundmeier R. Natural Language Processing to Identify Infants Aged 90 Days and Younger With Fevers Prior to Presentation. Hospital Pediatrics 2024, 15: e1-e5. PMID: 39679596, PMCID: PMC12163744, DOI: 10.1542/hpeds.2024-008051.Peer-Reviewed Original ResearchElectronic health recordsEmergency departmentNatural language processing algorithmsElectronic health record dataPediatric Emergency Care Applied Research Network RegistryFebrile infantsNatural language processingCross-sectional studyTrauma-related diagnosesPositive predictive valueHealth recordsHealth systemDocumented feverClinical notesPre-EDNetwork registryCohort identificationVisitsLanguage processingNLP algorithmsPredictive valueInfantsFeverResearch studiesDiagnostic Performance of AAP-Recommended Inflammatory Markers in Febrile Infants Aged 60 Days or Younger.
Yankova L, McDaniel C, Kerns E, Shine A, Ruiz B, Caruso H, Aronson P. Diagnostic Performance of AAP-Recommended Inflammatory Markers in Febrile Infants Aged 60 Days or Younger. 2024, 155 PMID: 39636262, DOI: 10.1542/peds.2024-068856.Peer-Reviewed Original ResearchProcalcitonin Use After Clinical Practice Guideline and QI Intervention for Febrile Infants.
Shine A, Bryan M, Brown M, Aronson P, McDaniel C. Procalcitonin Use After Clinical Practice Guideline and QI Intervention for Febrile Infants. Hospital Pediatrics 2024, 14: e455-e457. PMID: 39295527, DOI: 10.1542/hpeds.2024-007906.Peer-Reviewed Original ResearchParental Preferences and Shared Decision-Making for the Management of Febrile Young Infants.
Sylvestre P, Aronson P, Yannopoulos A, Poirier C, Gaucher N, Burstein B. Parental Preferences and Shared Decision-Making for the Management of Febrile Young Infants. 2024, 154 PMID: 39285842, PMCID: PMC11422194, DOI: 10.1542/peds.2024-066420.Peer-Reviewed Original ResearchDecisional involvementFocus groupsMedical recommendationsFebrile young infantsSequential explanatory mixed-methods studyExplanatory mixed-methods studyAspects of careStressful aspectsInfant medical careQualitative focus groupsCross-sectional questionnaireMixed-methods studyParental preferencesLumbar punctureDecision-making experiencesTertiary pediatric hospitalTailored informationYoung infantsMedical careMedical teamSupportive relationshipsInfant careManagement of febrile young infantsPediatric hospitalFamily expectationsDisparities in Guideline Adherence for Febrile Infants in a National Quality Improvement Project.
McDaniel C, Truschel L, Kerns E, Polanco Y, Liang D, Gutman C, Cunningham S, Rooholamini S, Thull-Freedman J, Jennings B, Magee S, Aronson P. Disparities in Guideline Adherence for Febrile Infants in a National Quality Improvement Project. 2024, 154 PMID: 39155728, PMCID: PMC11350103, DOI: 10.1542/peds.2024-065922.Peer-Reviewed Original ResearchConceptsQuality improvementDelivery of evidence-based careStandard careEmergency departmentNational quality improvement projectNon-Hispanic black infantsEvidence-based careQuality improvement projectDocumentation of follow-upAssociation of raceNon-Hispanic white infantsClinical practice guidelinesCross-sectional studyPediatrics clinical practice guidelineQI collaborativeEquitable deliveryGuideline implementationFollow-upEthnic disparitiesGuideline adherenceGuideline-concordantIntervention periodAmerican Academy of Pediatrics clinical practice guidelineImprovement projectPractice guidelinesDisposition and Follow-up for Low-Risk Febrile Infants: A Secondary Analysis of a Multicenter Study.
Kannikeswaran N, Spencer P, Tedford N, Truschel L, Chu J, Dingeldein L, Waseem M, Chow J, Lababidi A, Theiler C, Bhalodkar S, Yan X, Lou X, Fernandez R, Aronson P, Lion K, Gutman C. Disposition and Follow-up for Low-Risk Febrile Infants: A Secondary Analysis of a Multicenter Study. Hospital Pediatrics 2024, 14: e379-e384. PMID: 39113626, PMCID: PMC11358591, DOI: 10.1542/hpeds.2024-007850.Peer-Reviewed Original ResearchConceptsFebrile infantsFollow-upPrimary care providersElectronic health record documentationElectronic health recordsDischarged infantsEmergency departmentED dispositionLow riskAmerican Academy of Pediatrics guidelinesInvasive bacterial infectionsSecondary analysisCross-sectional studyMulticenter studyPost-discharge follow-upPediatric guidelinesWeekday visitsBacterial infectionsInfantsQuality of careAmerican AcademyMulticenterCare planningCare providersPatient-centeredManagement of race, ethnicity, and language data in the pediatric emergency department
Gutman C, Hartford E, Gifford S, Ford V, Bouvay K, Pickett M, Tran T, Slade N, Piroutek M, Chung S, Roach B, Hincapie M, Hoffmann J, Lin K, Kotler H, Pulcini C, Rose J, Bergmann K, Cheng T, St. Pierre Hetz R, Yan X, Lou X, Fernandez R, Aronson P, Lion K, Group T. Management of race, ethnicity, and language data in the pediatric emergency department. Academic Emergency Medicine 2024, 31: 1184-1187. PMID: 38808384, PMCID: PMC11577209, DOI: 10.1111/acem.14947.Peer-Reviewed Original ResearchImproving Guideline-Concordant Care for Febrile Infants Through a Quality Improvement Initiative.
McDaniel C, Kerns E, Jennings B, Magee S, Biondi E, Flores R, Aronson P. Improving Guideline-Concordant Care for Febrile Infants Through a Quality Improvement Initiative. 2024, 153 PMID: 38682245, DOI: 10.1542/peds.2023-063339.Peer-Reviewed Original ResearchConceptsClinical practice guidelinesFebrile infantsAmerican Academy of Pediatrics clinical practice guidelineSecondary measuresAAP clinical practice guidelinesPediatrics clinical practice guidelineInvasive bacterial infectionsQI collaborativeIntervention bundleAdherence to specific recommendationsDischarge of infantsGuideline-concordant careInfants aged 8Clinical practice guideline recommendationsPrimary measureQuality improvementOral antibioticsEmergency department dischargePositive urinalysisAssociated with improvementsQualifying infantsQuality improvement initiativesAdministered antibioticsGuideline recommendationsCerebrospinal fluidChanging patterns of routine laboratory testing over time at children's hospitals
Tchou M, Hall M, Markham J, Stephens J, Steiner M, McCoy E, Aronson P, Shah S, Molloy M, Cotter J. Changing patterns of routine laboratory testing over time at children's hospitals. Journal Of Hospital Medicine 2024, 19: 671-679. PMID: 38643414, PMCID: PMC11296890, DOI: 10.1002/jhm.13372.Peer-Reviewed Original ResearchTesting ratesChildren's hospitalED revisitsLength of stayRetrospective cohort study of children aged 0Study of children aged 0Annual testing ratesLaboratory testing ratesPediatric Health Information System databaseHealth Information System databaseChildren aged 0Case mix indexInformation System databaseResource utilization trendsRetrospective cohort studyAged 0Group hospitalsPatient daysReadmission ratesPatient outcomesSeparate hospitalsHospitalSystem databaseUtilization trendsMulti-centerPredictors of Invasive Bacterial Infection in Febrile Infants Aged 2 to 6 Months in the Emergency Department
Green R, Sartori L, Florin T, Aronson P, Lee B, Chamberlain J, Hunt K, Michelson K, Nigrovic L. Predictors of Invasive Bacterial Infection in Febrile Infants Aged 2 to 6 Months in the Emergency Department. The Journal Of Pediatrics 2024, 270: 114017. PMID: 38508484, DOI: 10.1016/j.jpeds.2024.114017.Peer-Reviewed Original Research“Let Us Take Care of the Medicine”: A Qualitative Analysis of Physician Communication When Caring for Febrile Infants
Gutman C, Fernandez R, McFarlane A, Krajewski J, Lion K, Aronson P, Bylund C, Holmes S, Fisher C. “Let Us Take Care of the Medicine”: A Qualitative Analysis of Physician Communication When Caring for Febrile Infants. Academic Pediatrics 2024, 24: 949-956. PMID: 38458491, PMCID: PMC11705713, DOI: 10.1016/j.acap.2024.03.002.Peer-Reviewed Original ResearchPatient-centered communicationPatient-centerednessPhysicians' assumptionsEmergency departmentThematic analysis of interview transcriptsParent-physician interactionsAnalysis of interview transcriptsAcademic pediatric emergency departmentIdentification of themesPediatric emergency departmentHealth inequalitiesPhysician communicationThematic saturationPhysicians' perceptionsED physiciansHealth careSemistructured interviewsInfant guidelinesThematic analysisInterview transcriptsPhysiciansCareHealthMethods approachManagement of febrile infantsPhlebotomy‐free days in children hospitalized with common infections and their association with clinical outcomes
Collins M, Hall M, Shah S, Molloy M, Aronson P, Cotter J, Steiner M, McCoy E, Tchou M, Stephens J, Markham J. Phlebotomy‐free days in children hospitalized with common infections and their association with clinical outcomes. Journal Of Hospital Medicine 2024, 19: 251-258. PMID: 38348499, PMCID: PMC11155307, DOI: 10.1002/jhm.13282.Peer-Reviewed Original ResearchCare of hospitalized childrenHospital quality measuresCross-sectional study of childrenPatient Refined Diagnosis Related GroupsPediatric Health Information System databaseHealth Information System databaseCross-sectional studyClinical outcomesDiagnosis Related GroupsInformation System databaseInterhospital transferIn-hospital mortalityMedical complexityStudy of childrenLaboratory blood testsTotal hospital LOSAssociated with outcomeAdjustment outcomesBlood testsOsteoarticular infectionsHospitalSystem databaseHospital LOSQuality measuresRelated groupsInfants With Hypothermia: Are They Just Like Febrile Infants?
Yankova L, Aronson P. Infants With Hypothermia: Are They Just Like Febrile Infants? Hospital Pediatrics 2024, 14: e161-e163. PMID: 38312018, DOI: 10.1542/hpeds.2023-007641.Commentaries, Editorials and LettersFebrile infants aged ≤60 days: evaluation and management in the emergency department.
Palladino L, Woll C, Aronson P. Febrile infants aged ≤60 days: evaluation and management in the emergency department. Pediatric Emergency Medicine Practice 2024, 21: 1-28. PMID: 38266065.Peer-Reviewed Original ResearchConceptsInvasive bacterial infectionsBacterial infectionsManagement of febrile young infantsAmerican Academy of Pediatrics clinical practice guidelineYoung infantsFebrile young infantsPediatrics clinical practice guidelineEmergency departmentUrinary tract infectionRisk stratification toolPositive viral testClinical practice guidelinesTract infectionsViral testingEmergency cliniciansSevere outcomesAmerican AcademyInfectionPractice guidelinesInfantsDepartmentFeverEmergency
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