2025
Modeling decision-making under uncertainty with qualitative outcomes.
Korem N, Duek O, Jia R, Wertheimer E, Metviner S, Grubb M, Levy I. Modeling decision-making under uncertainty with qualitative outcomes. PLOS Computational Biology 2025, 21: e1012440. PMID: 40029903, PMCID: PMC11918403, DOI: 10.1371/journal.pcbi.1012440.Peer-Reviewed Original ResearchConnectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors
Ben-Zion Z, Simon A, Rosenblatt M, Korem N, Duek O, Liberzon I, Shalev A, Hendler T, Levy I, Harpaz-Rotem I, Scheinost D. Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors. JAMA Network Open 2025, 8: e250331. PMID: 40063028, PMCID: PMC11894499, DOI: 10.1001/jamanetworkopen.2025.0331.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingPosttraumatic stress disorderClinician-Administered PTSD Scale for DSM-5Months post-traumaFunctional magnetic resonance imagingTrauma survivorsDSM-5Post-traumaPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptom severityPosttraumatic stress disorder symptom trajectoriesPosttraumatic stress disorder severityTask-based fMRI dataAnterior default modePredictive of symptomsFollow-up assessmentDevelopment of effective personalized treatmentsComprehensive clinical assessmentClinician-AdministeredNeurobiological indicesPosttraumatic psychopathologyHyperarousal symptomsCentral executiveTrauma exposureSalience networkThe Interplay Between Respiratory Syncytial Virus and Asthma Inception: Insights Gained From the COVID‐19 Pandemic
Amram T, Duek O, Golan‐Tripto I, Goldbart A, Greenberg D, Hazan G. The Interplay Between Respiratory Syncytial Virus and Asthma Inception: Insights Gained From the COVID‐19 Pandemic. Pediatric Pulmonology 2025, 60: e27474. PMID: 39760467, PMCID: PMC11748096, DOI: 10.1002/ppul.27474.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusYears of ageSyncytial virusRespiratory syncytial virus bronchiolitisRespiratory syncytial virus infectionRespiratory syncytial virus exposureRSV-induced inflammationRespiratory syncytial virus activityMultivariate logistic regressionAirway changesAsthma inceptionRetrospective studyAsthma surrogateIncreased riskLogistic regressionAsthmaCause of asthmaCOVID-19 pandemicHealthcare organizationsPredispositionIncreased rateChildrenCOVID-19AgeVirus
2023
Comparative Effectiveness of Intracranial Pressure Monitoring on 6-Month Outcomes of Critically Ill Patients With Traumatic Brain Injury
Nattino G, Gamberini L, Brissy O, Carrara G, Chesnut R, Chiarini V, Chieregato A, Csomos A, Fleming J, Gradisek P, Kaps R, Kyprianou T, Lazar I, Lemeshow S, Mikaszewska-Sokolewicz M, Paci G, Rossi C, Temkin N, Xirouchaki N, Giugni A, Bertolini G, Agostini F, Ajmone-Cat C, Bassi G, Bekos V, Bellin M, Bocci M, Bonato V, Bonato A, Bonizzoli M, Bonucci P, Bottazzi A, Calamai I, Calicchio G, Carlin F, Casagli S, Castioni C, Ciceri R, Cocciolo F, Crestan E, Csato G, Cseplo P, Curto F, Dąbrowski W, De Cristofaro A, De Luca A, Duda I, Duek O, Bakó B, Fagoni N, Fassini P, Ferri E, Filekovic S, Fiore G, Gamberini E, Gattari D, Gianni M, Dessena M, Giuntini R, Guido S, Gyulai R, Hadash A, Hribar R, Ilia S, Jankovic V, Jurekovic V, Jereb M, Kapias M, Karadzic D, Kasnik D, Vaggelis V, Szaszi A, Kompan J, Kyriakides E, Lagomarsino S, Lamborghini S, Livigni S, Malacarne P, Martelli M, Martin M, Martino C, Marudi A, Melis M, Mengoli F, Mirkovic T, Mizak W, Munari M, Nardai G, Nascimben E, Natalini G, Negro G, Nemes C, Bernasconi M, Pagani M, Parrini V, Partala P, Pastorelli M, Pellicioli I, Perino Bert P, Petrucci N, Piva S, Poole D, Portolani L, Radrizzani D, Rekas A, Robak P, Rosano A, Ruggeri P, Sacchi M, Sárkány Á, Skoti M, Skrt A, Spagarino E, Sulkowski W, Szedlák B, Terzitta M, Tinturini R, Tofani R, Tselioti P, Vecchiarelli A, Venturini E, Visconti S, Zompanti V, Zoppellari R. Comparative Effectiveness of Intracranial Pressure Monitoring on 6-Month Outcomes of Critically Ill Patients With Traumatic Brain Injury. JAMA Network Open 2023, 6: e2334214. PMID: 37755832, PMCID: PMC10534270, DOI: 10.1001/jamanetworkopen.2023.34214.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryIntensive care unitICP monitoringIntracranial pressureCohort studyBrain injuryGlasgow Outcome Scale Extended scoreBrain Trauma Foundation guidelinesFrequent medical interventionsMid-term outcomesProspective cohort studyDays of injuryRelevant adverse effectsIntracranial pressure monitoringIll patientsMedical therapyCare unitFunctional disabilityPersistent elevationPoor outcomeFoundation guidelinesTreatment choiceMAIN OUTCOMEPressure monitoringPatients
2022
Longitudinal volumetric evaluation of hippocampus and amygdala subregions in recent trauma survivors
Ben-Zion Z, Korem N, Spiller TR, Duek O, Keynan JN, Admon R, Harpaz-Rotem I, Liberzon I, Shalev AY, Hendler T. Longitudinal volumetric evaluation of hippocampus and amygdala subregions in recent trauma survivors. Molecular Psychiatry 2022, 28: 657-667. PMID: 36280750, PMCID: PMC9918676, DOI: 10.1038/s41380-022-01842-x.Peer-Reviewed Original ResearchConceptsEmergency departmentAmygdala subregionsPTSD diagnosisGeneral hospital emergency departmentLeft amygdala volumeHospital emergency departmentRight hippocampus volumeCA1 hippocampal subregionRecent trauma survivorsTrauma survivorsCivilian trauma survivorsED admissionEligible participantsHippocampus volumeAmygdala volumeHippocampal subregionsVulnerability traitsDisorder pathogenesisClinical InterviewModerate evidenceHippocampus subregionsTrauma exposureStructural MRIRobust evidenceLower initial volumeDelirium screening in an acute care setting with a machine learning classifier based on routinely collected nursing data: A model development study
Spiller TR, Tufan E, Petry H, Böttger S, Fuchs S, Duek O, Ben-Zion Z, Korem N, Harpaz-Rotem I, von Känel R, Ernst J. Delirium screening in an acute care setting with a machine learning classifier based on routinely collected nursing data: A model development study. Journal Of Psychiatric Research 2022, 156: 194-199. PMID: 36252349, DOI: 10.1016/j.jpsychires.2022.10.018.Peer-Reviewed Original ResearchConceptsDelirium Observation ScaleAcute care settingNursing dataCare settingsSingle tertiary teaching hospitalPatients 18 yearsTertiary teaching hospitalDelirium prediction modelSuch screening programsDelirium screeningAcute careMean ageTeaching hospitalInclusion criteriaScreening programDeliriumPatientsClinical practiceTotal scoreDemographic characteristicsCharacteristic curveScreening procedureModel development studiesRiskAdditional measuresComparative effectiveness of group v. individual trauma-focused treatment for posttraumatic stress disorder in veterans
Spiller TR, Duek O, Buta E, Gross G, Smith NB, Harpaz-Rotem I. Comparative effectiveness of group v. individual trauma-focused treatment for posttraumatic stress disorder in veterans. Psychological Medicine 2022, 53: 4561-4568. PMID: 35959560, PMCID: PMC10388318, DOI: 10.1017/s0033291722001441.Peer-Reviewed Original ResearchConceptsGroup cognitive processing therapyCognitive processing therapyPosttraumatic stress disorderIndividual cognitive processing therapyPTSD symptom severitySymptom severityStress disorderReal-world effectivenessComparative effectiveness studiesResidential treatmentEffective treatmentComparative effectivenessVeterans AffairsEffectiveness studiesPTSD ChecklistPTSD severityGroup therapySeverityVeteransTreatmentDSM-5Group V.TherapyDisordersSmall reduction
2013
Reward sensitivity and anger in euthymic bipolar disorder
Duek O, Osher Y, Belmaker RH, Bersudsky Y, Kofman O. Reward sensitivity and anger in euthymic bipolar disorder. Psychiatry Research 2013, 215: 95-100. PMID: 24230992, DOI: 10.1016/j.psychres.2013.10.028.Peer-Reviewed Original ResearchConceptsSingle Key Impulsivity ParadigmProbabilistic classification taskUltimatum gameReward sensitivityUnfair offersEuthymic stateAdult bipolar disorder patientsBipolar disorderEuthymic bipolar disorderUse of tasksPunishment learningResidual angerApproach systemHC participantsFair offersAngerRewardBipolar disorder patientsHC groupDisorder patientsParticipantsTaskPunishmentClassification taskBAS
2011
Differential long term effects of early diisopropylfluorophosphate exposure in Balb/C and C57Bl/J6 mice
Lin T, Duek O, Dori A, Kofman O. Differential long term effects of early diisopropylfluorophosphate exposure in Balb/C and C57Bl/J6 mice. International Journal Of Developmental Neuroscience 2011, 30: 113-120. PMID: 22197972, DOI: 10.1016/j.ijdevneu.2011.12.004.Peer-Reviewed Original ResearchConceptsLong-term effectsSwim testIrreversible acetylcholinesterase inhibitor diisopropylfluorophosphateBALB/c miceBALB/c strainPostnatal day 14BALB/cDifferential long-term effectsSub-toxic dosePostnatal administrationC miceMore immobilityDay 14Anxiety behaviorDFP pretreatmentC57BL/6J strainSweet preferenceConsecutive daysMouse strainsC strainMiceAge 3Term effectsFirst sessionSecond sessionAcetylcholinesterase inhibitor pretreatment alters stress-induced expression of acetylcholinesterase transcripts in the mouse brain
Dori A, Oriel S, Livneh U, Duek O, Lin T, Kofman O. Acetylcholinesterase inhibitor pretreatment alters stress-induced expression of acetylcholinesterase transcripts in the mouse brain. Neuroscience 2011, 183: 90-98. PMID: 21453753, DOI: 10.1016/j.neuroscience.2011.03.044.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholinesteraseAnalysis of VarianceAnimalsBrainCholinesterase InhibitorsDisease Models, AnimalDose-Response Relationship, DrugDrug Administration ScheduleFemaleGene Expression Regulation, EnzymologicIsoflurophateMaze LearningMiceMice, Inbred C57BLReaction TimeRNA, MessengerSpecies SpecificityStatistics as TopicStress, PsychologicalConceptsHomecage controlsC57BL/6 miceRestraint stressC57 BL/6 miceCD-1CD-1 miceSoluble splice variantAChE-R expressionExpression of AChEBL/6 miceTreatment groupsDays pretreatmentAnxiety behaviorMouse brainBrain regionsDFP pretreatmentStress-induced changesPrefrontal cortexMiceEffect of pretreatmentAmygdalaMazeTranscript expressionPretreatmentStress-induced expression
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