2025
Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors
Ben-Zion Z, Simon A, Rosenblatt M, Korem N, Duek O, Liberzon I, Shalev A, Hendler T, Levy I, Harpaz-Rotem I, Scheinost D. Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors. JAMA Network Open 2025, 8: e250331. PMID: 40063028, PMCID: PMC11894499, DOI: 10.1001/jamanetworkopen.2025.0331.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingPosttraumatic stress disorderClinician-Administered PTSD Scale for DSM-5Months post-traumaFunctional magnetic resonance imagingTrauma survivorsDSM-5Post-traumaPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptom severityPosttraumatic stress disorder symptom trajectoriesPosttraumatic stress disorder severityTask-based fMRI dataAnterior default modePredictive of symptomsFollow-up assessmentDevelopment of effective personalized treatmentsComprehensive clinical assessmentClinician-AdministeredNeurobiological indicesPosttraumatic psychopathologyHyperarousal symptomsCentral executiveTrauma exposureSalience networkModeling decision-making under uncertainty with qualitative outcomes.
Korem N, Duek O, Jia R, Wertheimer E, Metviner S, Grubb M, Levy I. Modeling decision-making under uncertainty with qualitative outcomes. PLOS Computational Biology 2025, 21: e1012440. PMID: 40029903, PMCID: PMC11918403, DOI: 10.1371/journal.pcbi.1012440.Peer-Reviewed Original Research
2023
Biological rhythms in COVID-19 vaccine effectiveness in an observational cohort study of 1.5 million patients
Hazan G, Duek O, Alapi H, Mok H, Ganninger A, Ostendorf E, Gierasch C, Chodick G, Greenberg D, Haspel J. Biological rhythms in COVID-19 vaccine effectiveness in an observational cohort study of 1.5 million patients. Journal Of Clinical Investigation 2023, 133: e167339. PMID: 37053011, PMCID: PMC10231992, DOI: 10.1172/jci167339.Peer-Reviewed Original ResearchConceptsCOVID-19 vaccinationBreakthrough infectionsVaccine effectivenessVaccination timingCOVID-19 breakthrough infectionsCOVID-19-related hospitalizationCOVID-19 vaccine effectivenessBasic immune processesSecond booster doseObservational cohort studyEmergency department visitsMass vaccination programBooster doseVaccination timeBooster dosesCohort studyOlder patientsPatient ageDepartment visitsVaccine protectionCox regressionIsraeli cohortClinical endpointsVaccination programImmunization time
2022
Longitudinal volumetric evaluation of hippocampus and amygdala subregions in recent trauma survivors
Ben-Zion Z, Korem N, Spiller TR, Duek O, Keynan JN, Admon R, Harpaz-Rotem I, Liberzon I, Shalev AY, Hendler T. Longitudinal volumetric evaluation of hippocampus and amygdala subregions in recent trauma survivors. Molecular Psychiatry 2022, 28: 657-667. PMID: 36280750, PMCID: PMC9918676, DOI: 10.1038/s41380-022-01842-x.Peer-Reviewed Original ResearchConceptsEmergency departmentAmygdala subregionsPTSD diagnosisGeneral hospital emergency departmentLeft amygdala volumeHospital emergency departmentRight hippocampus volumeCA1 hippocampal subregionRecent trauma survivorsTrauma survivorsCivilian trauma survivorsED admissionEligible participantsHippocampus volumeAmygdala volumeHippocampal subregionsVulnerability traitsDisorder pathogenesisClinical InterviewModerate evidenceHippocampus subregionsTrauma exposureStructural MRIRobust evidenceLower initial volumeComparative effectiveness of group v. individual trauma-focused treatment for posttraumatic stress disorder in veterans
Spiller TR, Duek O, Buta E, Gross G, Smith NB, Harpaz-Rotem I. Comparative effectiveness of group v. individual trauma-focused treatment for posttraumatic stress disorder in veterans. Psychological Medicine 2022, 53: 4561-4568. PMID: 35959560, PMCID: PMC10388318, DOI: 10.1017/s0033291722001441.Peer-Reviewed Original ResearchConceptsGroup cognitive processing therapyCognitive processing therapyPosttraumatic stress disorderIndividual cognitive processing therapyPTSD symptom severitySymptom severityStress disorderReal-world effectivenessComparative effectiveness studiesResidential treatmentEffective treatmentComparative effectivenessVeterans AffairsEffectiveness studiesPTSD ChecklistPTSD severityGroup therapySeverityVeteransTreatmentDSM-5Group V.TherapyDisordersSmall reduction
2020
PROSAFE: a European endeavor to improve quality of critical care medicine in seven countries
Finazzi S, Paci G, Antiga L, Brissy O, Carrara G, Crespi D, Csato G, Csomos A, Duek O, Facchinetti S, Fleming J, Garbero E, Gianni M, Gradisek P, Kaps R, Kyprianou T, Lazar I, Mikaszewska-Sokolewicz M, Mondini M, Nattino G, Olivieri C, Poole D, Previtali C, Radrizzani D, Rossi C, Skurzak S, Tavola M, Xirouchaki N, Bertolini G, collaboration G. PROSAFE: a European endeavor to improve quality of critical care medicine in seven countries. Minerva Anestesiologica 2020, 86: 1305-1320. PMID: 33337119, DOI: 10.23736/s0375-9393.20.14112-9.Peer-Reviewed Original Research
2013
Reward sensitivity and anger in euthymic bipolar disorder
Duek O, Osher Y, Belmaker RH, Bersudsky Y, Kofman O. Reward sensitivity and anger in euthymic bipolar disorder. Psychiatry Research 2013, 215: 95-100. PMID: 24230992, DOI: 10.1016/j.psychres.2013.10.028.Peer-Reviewed Original ResearchConceptsSingle Key Impulsivity ParadigmProbabilistic classification taskUltimatum gameReward sensitivityUnfair offersEuthymic stateAdult bipolar disorder patientsBipolar disorderEuthymic bipolar disorderUse of tasksPunishment learningResidual angerApproach systemHC participantsFair offersAngerRewardBipolar disorder patientsHC groupDisorder patientsParticipantsTaskPunishmentClassification taskBAS
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply