2024
Distinct epigenetic and transcriptional profiles of Epstein-Barr virus (EBV) positive and negative primary CNS lymphomas
Hai L, Friedel D, Hinz F, Hoffmann D, Doubrovinskaia S, Rohdjess H, Weidenauer K, Denisova E, Scheffler G, Kessler T, Kourtesakis A, Herold-Mende C, Henegariu O, Baehring J, Dietrich J, Brors B, Wick W, Sahm F, Kaulen L. Distinct epigenetic and transcriptional profiles of Epstein-Barr virus (EBV) positive and negative primary CNS lymphomas. Neuro-Oncology 2024, noae251. PMID: 39575767, DOI: 10.1093/neuonc/noae251.Peer-Reviewed Original ResearchPrimary CNS lymphomaEpstein-Barr virusB cell receptorCNS lymphomaTargeted therapyEpigenetic profilesB cellsDiffuse large B-cell lymphomaLarge B-cell lymphomaB-cell lymphomaPromoter region hypermethylationEBV oncogeneEBV lymphomasEBV- tumorsEPIC methylation arrayWnt/beta-catenin signalingEBV diseaseBiological subtypesUnsupervised cluster analysisInterleukin-10Promoter methylationLymphomaSyk kinase activityBrain tumorsMutational landscapePATH-35. INTEGRATED GENOMIC ANALYSES OF IMMUNODEFICIENCY-ASSOCIATED EPSTEIN-BARR VIRUS- (EBV) POSITIVE PRIMARY CNS LYMPHOMAS
Kaulen L, Denisova E, Hinz F, Hai L, Friedel D, Henegariu O, Hoffmann D, Ito J, Kourtesakis A, Lehnert P, Doubrovinskaia S, Karschnia P, von Baumgarten L, Kessler T, Baehring J, Brors B, Sahm F, Wick W. PATH-35. INTEGRATED GENOMIC ANALYSES OF IMMUNODEFICIENCY-ASSOCIATED EPSTEIN-BARR VIRUS- (EBV) POSITIVE PRIMARY CNS LYMPHOMAS. Neuro-Oncology 2024, 26: viii186-viii186. PMCID: PMC11553229, DOI: 10.1093/neuonc/noae165.0734.Peer-Reviewed Original ResearchPrimary CNS lymphomaEpstein-Barr virusRNAseq dataSingle nucleotide variantsCopy number variantsComprehensive genetic analysisRNA sequencing dataCopy number gainCNS lymphomaGermline controlTumor microenvironmentNucleotide variantsSequence dataTranscript groupsTargeting motifGenetic analysisGenetic landscapeJAK/STAT signalingCytotoxic T cell responsesRNA sequencingTolerogenic tumor microenvironmentAberrant somatic hypermutationExpression of CD70T regulatory cellsT cell responsesP20.12.B INTEGRATED GENETIC ANALYSES OF IMMUNODEFICIENCY-ASSOCIATED EPSTEIN-BARR VIRUS- (EBV) POSITIVE PRIMARY CNS LYMPHOMAS
Kaulen L, Denisova E, Hinz F, Hai L, Friedel D, Henegariu O, Hoffmann D, Ito J, Kourtesakis A, Lehnert P, Doubrovinskaia S, Karschnia P, von Baumgarten L, Kessler T, Baehring J, Brors B, Sahm F, Wick W. P20.12.B INTEGRATED GENETIC ANALYSES OF IMMUNODEFICIENCY-ASSOCIATED EPSTEIN-BARR VIRUS- (EBV) POSITIVE PRIMARY CNS LYMPHOMAS. Neuro-Oncology 2024, 26: v118-v118. PMCID: PMC11485591, DOI: 10.1093/neuonc/noae144.399.Peer-Reviewed Original ResearchPrimary CNS lymphomaEpstein-Barr virusRNAseq dataSingle nucleotide variantsCopy number variantsComprehensive genetic analysisRNA sequencing dataCNS lymphomaCopy number gainTumor microenvironmentGermline controlNucleotide variantsSequence dataTranscript groupsCytotoxic T cell responsesEpstein-Barr virus-positiveTargeting motifGenetic analysisGenetic landscapeJAK/STAT signalingTolerogenic tumor microenvironmentRNA sequencingAberrant somatic hypermutationExpression of CD70T regulatory cells
2023
Integrated genetic analyses of immunodeficiency-associated Epstein-Barr virus- (EBV) positive primary CNS lymphomas
Kaulen L, Denisova E, Hinz F, Hai L, Friedel D, Henegariu O, Hoffmann D, Ito J, Kourtesakis A, Lehnert P, Doubrovinskaia S, Karschnia P, von Baumgarten L, Kessler T, Baehring J, Brors B, Sahm F, Wick W. Integrated genetic analyses of immunodeficiency-associated Epstein-Barr virus- (EBV) positive primary CNS lymphomas. Acta Neuropathologica 2023, 146: 499-514. PMID: 37495858, PMCID: PMC10412493, DOI: 10.1007/s00401-023-02613-w.Peer-Reviewed Original ResearchConceptsPrimary CNS lymphomaCNS lymphomaCytotoxic T cell responsesDistinct clinicopathological entityT cell responsesRegulatory cellsClinicopathological entityEpstein-BarrInferior prognosisMonocyte fractionM2 macrophagesJAK/STATMast cellsTumor microenvironmentAberrant somatic hypermutationMolecular classificationComprehensive genetic analysisBulk RNAseq dataStrong expressionChromosomal aberrationsGenetic alterationsPathological informationNumber gainCD70Lymphoma
2022
P11.46.A Whole exome sequencing identifies novel SLIT2 mutations in primary CNS lymphoma
Kaulen L, Erson-Omay E, Henegariu O, Karschnia P, Huttner A, Günel M, Baehring J. P11.46.A Whole exome sequencing identifies novel SLIT2 mutations in primary CNS lymphoma. Neuro-Oncology 2022, 24: ii68-ii68. PMCID: PMC9443199, DOI: 10.1093/neuonc/noac174.235.Peer-Reviewed Original ResearchPrimary CNS lymphomaCNS lymphomaOverall survivalExtension cohortEpstein-Barr virus statusKaplan-Meier methodLog-rank testCBio Cancer Genomics PortalReporter luciferase assaysFree survivalShorter OSTumor DNA samplesPCNSL patientsClinical outcomesShorter PFSSomatic insertions/deletionsVirus statusFavorable outcomeLymphoid malignanciesClinical observationsTumor tissuePersonalized careCDKN2A lossCopy number alterationsCohort