2025
Superior Semicircular Canal Dehiscence Repair With Hydroxyapetite Cement via a Transmastoid Approach
Shah H, Ninan S, Shah R, Reeder A, Kveton J, Schwartz N. Superior Semicircular Canal Dehiscence Repair With Hydroxyapetite Cement via a Transmastoid Approach. Laryngoscope Investigative Otolaryngology 2025, 10: e70164. PMID: 40521131, PMCID: PMC12166310, DOI: 10.1002/lio2.70164.Peer-Reviewed Original ResearchSuperior semicircular canal dehiscenceSuperior semicircular canal dehiscence repairTransmastoid approachCase seriesSuccess rate of surgical repairMedian follow-up timeRate of surgical repairSemicircular canal dehiscenceTemporal bone scansTertiary referral centerMiddle fossa approachEffective management of patientsRetrospective case seriesManagement of patientsDehiscence repairTransmastoid repairCanal dehiscenceDehiscence sizeComplication rateSurgical repairPostoperative imagingReferral centerBone scanFailure rateFemale patientsThe implementation of artificial intelligence in serial monitoring of post gamma knife vestibular schwannomas: A pilot study
Singh M, Jester N, Lorr S, Briano A, Schwartz N, Mahajan A, Chiang V, Tommasini S, Wiznia D, Buono F. The implementation of artificial intelligence in serial monitoring of post gamma knife vestibular schwannomas: A pilot study. Clinical Imaging 2025, 123: 110495. PMID: 40388858, DOI: 10.1016/j.clinimag.2025.110495.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryVestibular schwannomaPost-GKSTumor growthVS volumeHalting tumor growthRetrospective cohort studyAssess treatment efficacyManual segmentationHearing lossBenign tumorsPaired t-testT1-weighted MRI scansAssess statistical significanceCohort studyDice similarity coefficientNeurological functionTreatment efficacyClinical monitoringMRI scansStatistical significancePercentage changeSchwannomaSpatial overlapTumorPrevalence and risk factors for underlying vestibular weakness in cochlear implant candidates
Reeder A, Shah R, Canner J, Schneider E, Vining E, Kveton J, Schwartz N. Prevalence and risk factors for underlying vestibular weakness in cochlear implant candidates. European Archives Of Oto-Rhino-Laryngology 2025, 1-8. PMID: 40195189, DOI: 10.1007/s00405-025-09361-5.Peer-Reviewed Original ResearchCochlear implant candidatesVestibular weaknessImplant candidatesSeverity of hearing lossAudiological risk factorsRisk factorsDesignRetrospective cohort studyHigh riskCI candidatesHearing earIndicator of high riskAudiological dataHearing lossVestibular evaluationVNG testCaloric testUnilateral weaknessVestibular functionVestibular dysfunctionStudy designRetrospective cohort studyBilateral weaknessCohort studyAcademic hospitalDemographic variablesMedical comorbiditiesRisk factors for underlying bilateral vestibular weakness in cochlear implant candidates
Reeder A, Canner J, Schwartz N. Risk factors for underlying bilateral vestibular weakness in cochlear implant candidates. Otology & Neurotology Open 2025, 5: e066-e066. PMID: 40161476, PMCID: PMC11949288, DOI: 10.1097/ono.0000000000000066.Peer-Reviewed Original ResearchBilateral vestibular weaknessVestibular weaknessBilateral weaknessQuality of lifeCochlear implantationAudiological dataVestibular dysfunctionWorse-hearing earCochlear implant candidatesHigher body mass indexBody mass indexCI candidatesImplanted earHearing thresholdsImplant candidatesPrognostic indicatorVestibular evaluationRetrospective cohort studyVestibular testsCaloric testUnilateral weaknessVestibular functionCohort studyMass indexRisk factors
2024
Comparing the Accuracy and Reliability of ABC/2 and Planimetry for Vestibular Schwannoma Volume Assessment
Singh K, Abdou H, Panth N, Chiang V, Buono F, Schwartz N, Mahajan A. Comparing the Accuracy and Reliability of ABC/2 and Planimetry for Vestibular Schwannoma Volume Assessment. Otology & Neurotology 2024, 46: 196-200. PMID: 39792983, DOI: 10.1097/mao.0000000000004392.Peer-Reviewed Original ResearchConceptsTumor volume assessmentABC/2 methodVestibular schwannomaVolume assessmentPlanimetry methodTumor volumeTumor volume changesFollow-up scansOverestimate tumor volumePatients' quality of lifeTumor sizeRetrospective reviewIntracranial tumorsImprove clinical decision makingSubgroup analysisVolumetric assessmentTumorClinical decision makingQuality of lifePatients' qualityPatientsClinical settingPlanimetryImaging techniquesPositive correlationOver‐The‐Counter Hearing Aids: Are They Safe and Effective?
Shah R, Wilkins S, Panth N, Tyagi S, Dunn H, Bell M, Norgaard S, Guyer E, Schwartz N. Over‐The‐Counter Hearing Aids: Are They Safe and Effective? Otolaryngology 2024, 171: 1017-1026. PMID: 38769863, DOI: 10.1002/ohn.817.Peer-Reviewed Original ResearchOver-the-counter hearing aidsHearing aidsHearing lossOver-the-counterMild-to-moderate hearing lossModerate hearing lossOver-the-counter devicesEfficacy of prescriptionHearing levelPrescriptionFood and Drug AdministrationHearingStatistically significant advantageAverage differenceSafety profileAIDSDrug AdministrationAudioscanEfficacySafetyLoss patternsDifferencesTestStatisticallySignificant advantageThe Safety and Efficacy of Hydroxyapatite Repair of Cholesteatoma Skull Base Defects
Shah R, Reeder A, Wilkins S, Kveton J, Schwartz N. The Safety and Efficacy of Hydroxyapatite Repair of Cholesteatoma Skull Base Defects. OTO Open 2024, 8: e151. PMID: 38863486, PMCID: PMC11165677, DOI: 10.1002/oto2.151.Peer-Reviewed Original ResearchSkull base defectsLabyrinthine fistulaTegmen defectsCanal wallBase defectsRate of postoperative infectionMedical records of patientsRate of cholesteatoma recurrenceCholesteatoma recidivism ratesSemicircular canal fistulaSensorineural hearing lossElectronic medical records of patientsRate of recurrenceRecords of patientsRepair skull base defectsInner ear fistulaNonstatistically significant differenceHydroxyapatite groupCWD surgeryCWU surgeryPostoperative audiogramsCholesteatoma recurrenceMastoid infectionHearing lossPostoperative infection
2023
Hydroxyapatite Use in Repair of Lateral Skull Base CSF Leaks Via Transmastoid Approach: When Does It Work?
Shah R, Kveton J, Schwartz N. Hydroxyapatite Use in Repair of Lateral Skull Base CSF Leaks Via Transmastoid Approach: When Does It Work? Otology & Neurotology 2023, 44: 804-808. PMID: 37550871, DOI: 10.1097/mao.0000000000003973.Peer-Reviewed Original ResearchConceptsCSF leak repairTransmastoid approachTertiary level care hospitalSkull Base Cerebrospinal Fluid LeaksLeak repairHydroxyapatite cementPrior smoking historyTrans-mastoid approachPatients 18 yearsRetrospective cohort studyRecurrence of symptomsVP shunt placementPatient demographic factorsBenign intracranial hypertensionSpontaneous CSF leaksCerebrospinal fluid leakFailure rateSkull base repairAverage defect sizeRepair cohortRecurrent symptomsAdjuvant treatmentFormer smokersSmoking historyCohort studyOver‐The‐Counter Hearing Aids: Trends in Information‐Seeking Behavior
Panth N, Shah R, Judson B, Schwartz N. Over‐The‐Counter Hearing Aids: Trends in Information‐Seeking Behavior. Otolaryngology 2023, 169: 1691-1693. PMID: 37365970, DOI: 10.1002/ohn.406.Peer-Reviewed Original Research
2022
Virtual Surgical Planning for Accurate Placement of Bone-Anchored Hearing System.
Valdez C, Ninan S, Lee Y, Schwartz N. Virtual Surgical Planning for Accurate Placement of Bone-Anchored Hearing System. Ear, Nose & Throat Journal 2022, 1455613221140279. PMID: 36380528, DOI: 10.1177/01455613221140279.Peer-Reviewed Original Research
2021
Multifocal Skull Base Defects With Associated Spontaneous Cerebrospinal Fluid Leaks
Schwartz N, Brown KD, Sasaki-Adams D, Morgan SA, Zanation AM, Thorp BD, O’Connell B. Multifocal Skull Base Defects With Associated Spontaneous Cerebrospinal Fluid Leaks. Otology & Neurotology 2021, 42: e624-e628. PMID: 33416298, DOI: 10.1097/mao.0000000000003048.Peer-Reviewed Original ResearchConceptsSpontaneous CSF leaksSpontaneous cerebrospinal fluid leaksElevated intracranial pressureCerebrospinal fluid leakCSF leakSurgical repairSurgical outcomesIntracranial pressureFluid leakSkull basePatients 18 yearsPercent of patientsTertiary referral centerRetrospective case seriesBody mass indexCSF leak repairOverall success rateCSF leak patientsAfrican AmericansSkull base defectsLeak patientsReferral centerCase seriesClinical presentationMass index
2020
Audiologic Outcomes of Cochlear Implantation in Cochlear Malformations: A Comparative Analysis of Lateral Wall and Perimodiolar Electrode Arrays.
Schwartz N, Brown KD, Park LR. Audiologic Outcomes of Cochlear Implantation in Cochlear Malformations: A Comparative Analysis of Lateral Wall and Perimodiolar Electrode Arrays. Otology & Neurotology 2020, 41: e1201-e1206. PMID: 33433084, DOI: 10.1097/mao.0000000000002833.Peer-Reviewed Original ResearchConceptsCochlear malformationsCochlear implantationLateral wallCochlear implantsTertiary referral centerRetrospective case seriesCochlear nerve deficiencyInner ear malformationsPediatric cochlear implant recipientsType of malformationCochlear implant recipientsConsonant word scoresSpeech perception outcomesReferral centerAudiologic outcomesCase seriesOutcome advantageEar malformationsRecognition outcomesMAIN OUTCOMESpeech perception scoresImplant recipientsMalformationsPerimodiolar electrode arrayPerception outcomesMRI surveillance following concurrent cochlear implantation in cases of vestibular schwannoma resection
Schwartz N, Rooth MA, Dillon MT, O'Connell BP, Dedmon MM, Huang BY, Brown KD. MRI surveillance following concurrent cochlear implantation in cases of vestibular schwannoma resection. American Journal Of Otolaryngology 2020, 41: 102518. PMID: 32451290, DOI: 10.1016/j.amjoto.2020.102518.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCochlear ImplantationCochlear NerveCranial Nerve NeoplasmsFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedMonitoring, PhysiologicNeuroma, AcousticOrgan Sparing TreatmentsPostoperative PeriodRetrospective StudiesVestibulocochlear NerveVestibulocochlear Nerve DiseasesConceptsInternal auditory canalConcurrent cochlear implantationVestibular schwannoma resectionIpsilateral internal auditory canalCerebellopontine angleSchwannoma resectionCochlear nerveCochlear implantationHead MRITranslabyrinthine vestibular schwannoma resectionCochlear implant magnetResidual tumor growthCI recipientsMagnetic resonance imaging (MRI) monitoringTranslabyrinthine excisionImplant magnetMRI surveillanceRetrospective reviewVS tumorsTumor recurrenceAuditory canalSerial monitoringCI magnetExcellent visualizationTumor growthLoss of Estrogen Receptors is Associated with Increased Tumor Aggression in Laryngeal Squamous Cell Carcinoma
Verma A, Schwartz N, Cohen DJ, Patel V, Nageris B, Bachar G, Boyan BD, Schwartz Z. Loss of Estrogen Receptors is Associated with Increased Tumor Aggression in Laryngeal Squamous Cell Carcinoma. Scientific Reports 2020, 10: 4227. PMID: 32144339, PMCID: PMC7060328, DOI: 10.1038/s41598-020-60675-2.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaERβ expressionCell carcinomaLaryngeal squamous cell carcinomaEstrogen receptor-dependent mechanismHigh ESR1 expressionClinical cancer stageCancer Genome AtlasImproved survivalTumor burdenPathological stageResponsive cancersCancer stageERα36 expressionHistopathological markersEstrogen receptorXenograft tumorsESR1 expressionTumor aggressionEpithelial samplesLSCCDependent mechanismGenome AtlasERα66CarcinomaSpontaneous Cerebrospinal Fluid Leaks from Multiple Anterior and Lateral Skull Base Defects
Schwartz N, Sasaki-Adams D, Brown K, Zanation A, Thorp B, O’Connell B. Spontaneous Cerebrospinal Fluid Leaks from Multiple Anterior and Lateral Skull Base Defects. Journal Of Neurological Surgery Part B Skull Base 2020, 81: s1-s272. DOI: 10.1055/s-0040-1702472.Peer-Reviewed Original ResearchThe Perforator Bone Chip as a Convenient and Effective Autologous Bone Graft for Middle Fossa Encephalocele Repair: A Technical Report
Webb T, Northam W, Dedmon M, Schwartz N, Sasaki-Adams D. The Perforator Bone Chip as a Convenient and Effective Autologous Bone Graft for Middle Fossa Encephalocele Repair: A Technical Report. Journal Of Neurological Surgery Part B Skull Base 2020, 81: s1-s272. DOI: 10.1055/s-0040-1702683.Peer-Reviewed Original Research
2019
Estrogen signaling and estrogen receptors as prognostic indicators in laryngeal cancer
Verma A, Schwartz N, Cohen DJ, Boyan BD, Schwartz Z. Estrogen signaling and estrogen receptors as prognostic indicators in laryngeal cancer. Steroids 2019, 152: 108498. PMID: 31539535, DOI: 10.1016/j.steroids.2019.108498.Peer-Reviewed Original ResearchConceptsSex hormone receptorsEstrogen receptorBreast cancerHormone receptorsCanonical estrogen receptorsAnti-estrogen therapyLoss of ERαSquamous cell carcinomaEstrogen receptor αHormone therapyPrognostic valueCell carcinomaPrognostic indicatorLaryngeal cancerPrognostic markerSex hormonesLSCC tumorsEstrogen signalingReceptor αTumor growthPathogenic markersEnhanced aggressionImportant modulatorERαCancer24R,25-Dihydroxyvitamin D3 regulates breast cancer cells in vitro and in vivo
Verma A, Cohen DJ, Schwartz N, Muktipaty C, Koblinski JE, Boyan BD, Schwartz Z. 24R,25-Dihydroxyvitamin D3 regulates breast cancer cells in vitro and in vivo. Biochimica Et Biophysica Acta (BBA) - General Subjects 2019, 1863: 1498-1512. PMID: 31125679, DOI: 10.1016/j.bbagen.2019.05.013.Peer-Reviewed Original ResearchConceptsEstrogen receptorMCF7 tumor growthBreast cancer patientsBreast cancer cell survivalBreast cancer xenograftsNarrow therapeutic windowMammary fat padDose-dependent increasePre-clinical studiesNull female miceMarker of invasionAnti-proliferative effectsBreast cancer cellsCell survivalCancer cell survivalTumor burdenAnti-tumorigenic propertiesVitamin DCancer patientsCancer xenograftsFemale miceHigh serumBreast cancerDihydroxyvitamin D3Therapeutic window
2017
Estradiol receptor profile and estrogen responsiveness in laryngeal cancer and clinical outcomes
Schwartz N, Verma A, Muktipaty C, Bivens C, Schwartz Z, Boyan BD. Estradiol receptor profile and estrogen responsiveness in laryngeal cancer and clinical outcomes. Steroids 2017, 142: 34-42. PMID: 29274403, DOI: 10.1016/j.steroids.2017.11.012.Peer-Reviewed Original ResearchConceptsLaryngeal cancerReceptor profileCancer cellsLaryngeal cancer patientsAnti-apoptotic effectsSteroid hormone receptorsClassical nuclear receptorsCancer cell linesClinical outcomesAnti-apoptotic potentialCancer patientsLaryngeal tumorsTreatment modalitiesSex hormonesClinical characterizationIndividual patientsEstrogen responsivenessHormone responsivenessDifferent cancer cellsCancerDifferent cancer cell linesHormone receptorsAdverse effectsReceptorsMembrane ER
2016
Rapid steroid hormone actions via membrane receptors
Schwartz N, Verma A, Bivens CB, Schwartz Z, Boyan BD. Rapid steroid hormone actions via membrane receptors. Biochimica Et Biophysica Acta 2016, 1863: 2289-2298. PMID: 27288742, DOI: 10.1016/j.bbamcr.2016.06.004.Peer-Reviewed Original ResearchConceptsDNA-binding sitesPhosphoinositide-3 kinaseClassical steroid hormone receptorsMembrane-bound receptorsNumber of pathwaysDevelopmental functionsGene transcriptionSteroid hormone actionSteroid hormonesImpact tumorigenesisCell cycleCellular activitiesMembrane receptorsPhospholipase DSteroid hormone receptorsPhospholipase CReceptor counterpartsRapid steroidCancer cellsNovel receptorPathwayDihydroxy vitamin D3Cytosolic receptorHormone actionHormone receptors
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