2025
Cancer genetics evaluation among individuals at risk for Lynch syndrome across all qualifying indications.
Singh V, Chen G, Sena A, Rafter T, Xicola R, Sharbatji M, Liu J, Brown Q, Brierley K, Healy C, Hughes M, Kashyap N, Llor X. Cancer genetics evaluation among individuals at risk for Lynch syndrome across all qualifying indications. Journal Of Clinical Oncology 2025, 43: 10616-10616. DOI: 10.1200/jco.2025.43.16_suppl.10616.Peer-Reviewed Original ResearchLynch syndromeInherited cancer syndromeFamily historyPersonal historyCancer syndromesFamily history of colorectal cancerColorectal cancerPersonal history of cancerFamily history of cancerYale New Haven Health SystemLS-related cancersGenetic testingLS-associated cancersCancer genetic evaluationAt-riskIdentification of at-risk individualsAt-risk individualsPathogenic variantsLS cancersComparison of categorical variablesIndividuals at-riskEO-CRCPearson chi-squareHealth systemDescriptive statisticsAt-risk cancer genetic syndrome identification (ARCAGEN-ID): Novel EHR integrated system to overcome disparities in identification and testing for cancer genetic syndromes.
Singh V, Chen G, Sena A, Rafter T, Xicola R, Sharbatji M, Liu J, Brown Q, Brierley K, Healy C, Hughes M, Kashyap N, Llor X. At-risk cancer genetic syndrome identification (ARCAGEN-ID): Novel EHR integrated system to overcome disparities in identification and testing for cancer genetic syndromes. Journal Of Clinical Oncology 2025, 43: 1600-1600. DOI: 10.1200/jco.2025.43.16_suppl.1600.Peer-Reviewed Original ResearchHereditary cancer syndromesOvercome disparitiesAt-riskGenetic testingHereditary cancer syndrome identificationCancer genetic syndromesPreventable cancer deathsMedicaid-insured individualsComplexity of guidelinesAt-risk individualsPathogenic variantsIndividuals at-riskNon-white individualsDecline testingLynch syndromeUnderserved populationsHealth systemNon-HispanicCancer syndromesChi-square testEligible individualsFamily historyInformational videoCancer deathGenetic counselingElectronic health record-based registry for identification of individuals at risk for hereditary cancer syndromes
Singh V, Rafter T, Sharbatji M, Liu J, Brown Q, Brierley K, Healy C, Xicola R, Kashyap N, Llor X. Electronic health record-based registry for identification of individuals at risk for hereditary cancer syndromes. Journal Of Medical Genetics 2025, 62: 457-463. PMID: 40350248, DOI: 10.1136/jmg-2025-110718.Peer-Reviewed Original ResearchConceptsHereditary cancer syndromesElectronic health recordsGenetic testingElectronic health record-based registryCancer syndromesIdentification of individualsFamily history of cancerFamily historyFamily history criteriaAt-riskHistory of cancerAt-risk individualsHealth recordsPathogenic variantsProspective identification of individualsRegistryActive patientsSyndrome identificationFamily relationshipsIncreased diagnostic rateCancer-related survivalStreamlined processProspective identificationIndividualsTesting needsCase Report: A health system’s experience using clinical decision support to promote note sharing after the 21st Century Cures Act
Iscoe M, Venkatesh A, Powers E, Kashyap N, Hsiao A, Millard H, Sangal R. Case Report: A health system’s experience using clinical decision support to promote note sharing after the 21st Century Cures Act. JAMIA Open 2025, 8: ooaf051. PMID: 40510806, PMCID: PMC12161449, DOI: 10.1093/jamiaopen/ooaf051.Peer-Reviewed Original ResearchClinical decision supportHealth system's experienceRegional health systemDecision supportPatient engagementCentury Cures ActHealth systemPortal accessClinical notesConsistent with prior research showingCures ActPromote complianceSensitive informationStudy periodLinear regressionPediatricObservational analysisPsychiatryPatients/proxiesNotesPatientsSupportHealthCliniciansResearch showA mixed-methods study assessing the performance of a clinical decision support tool for Clostridioides difficile testing for patients receiving laxatives
Peaper D, Rathod S, Sussman L, Azar M, Murdzek C, Roberts S, Tichy E, Topal J, Kashyap N, McManus D, Martinello R. A mixed-methods study assessing the performance of a clinical decision support tool for Clostridioides difficile testing for patients receiving laxatives. Infection Control And Hospital Epidemiology 2025, 46: 497-503. PMID: 40079209, PMCID: PMC12034449, DOI: 10.1017/ice.2025.30.Peer-Reviewed Original ResearchClinical decision supportAdvanced practice providersClinical decision support alertsClinical decision support toolMixed-methods studyPractice providersClinician interactionClinician concernsPhysician's instructionsTest orderingAttending physiciansMixed-methodsDoses of laxativesPatient riskLaxative useClinicians' rationaleCliniciansDecision support toolHospitalized patientsStudy periodDecision supportAttendanceCase seriesAntibiotic exposureResidentsP577: Decreasing disparities in inherited cancer syndromes through a systems approach: The At-Risk Cancer Genetic Syndrome Identification (ARCAGEN-ID) system
Xicola R, Singh V, Chen G, Senna A, Pugliese A, Hughes M, Rafter T, Liu J, Brown Q, Haight C, Kashyap N, Llor X. P577: Decreasing disparities in inherited cancer syndromes through a systems approach: The At-Risk Cancer Genetic Syndrome Identification (ARCAGEN-ID) system. Genetics In Medicine Open 2025, 3: 102425. DOI: 10.1016/j.gimo.2025.102425.Peer-Reviewed Original Research
2024
Improving cefazolin administration for surgical prophylaxis in reported penicillin allergy: A retrospective study of a health system intervention
Belmont A, Son M, Hyman J, You L, Su C, Kashyap N, Topal J, McManus D, Martinello R, Kwah J. Improving cefazolin administration for surgical prophylaxis in reported penicillin allergy: A retrospective study of a health system intervention. Journal Of Allergy And Clinical Immunology Global 2024, 4: 100377. PMID: 39830990, PMCID: PMC11742594, DOI: 10.1016/j.jacig.2024.100377.Peer-Reviewed Original ResearchPenicillin allergy labelHospital-wide guidelinesSurgical site infectionAllergy labelsSurgical patientsSevere allergic reactionsSurgical prophylaxisSite infectionAssociated with increased rates of surgical site infectionRate of surgical site infectionMulti-drug resistant infectionsAllergic reactionsPrevent surgical site infectionsFirst-line antibioticsFirst-line prophylaxisAdministration of cefazolinAssociated with increased ratesRetrospective cohort studyGuideline-directed therapyAdult surgical patientsPre-intervention groupPost-intervention groupPenicillin allergyPerioperative outcomesCefazolin administrationGuideline concordance of electronic health record order sets for hospital‐based treatment of alcohol withdrawal syndrome
Cohen S, Kashyap N, Steel T, Edelman E, Fiellin D, Joudrey P. Guideline concordance of electronic health record order sets for hospital‐based treatment of alcohol withdrawal syndrome. Journal Of Hospital Medicine 2024, 20: 550-561. PMID: 39580659, DOI: 10.1002/jhm.13556.Peer-Reviewed Original ResearchElectronic health recordsElectronic health record ordersTreatment of alcohol withdrawal syndromeSevere alcohol withdrawal syndromeTreatment of unhealthy alcohol useAlcohol withdrawal syndromeUnhealthy alcohol useAcute care hospitalsHospital organizationCross-sectional studyHospital-based treatmentCare practicesHealth recordsCare escalationGuideline concordanceSymptom assessmentCare hospitalProtocolized careRecord ordersAlcohol use disorderSymptom scoresAlcohol useSubstance useHospitalInconsistent definitionsFrom MedWreck to MedRec: A Call to Action to Improve Medication Reconciliation
Kashyap N, Jeffery S, Agresta T. From MedWreck to MedRec: A Call to Action to Improve Medication Reconciliation. Applied Clinical Informatics 2024, 15: 230-233. PMID: 37748724, PMCID: PMC10972679, DOI: 10.1055/a-2181-1847.Peer-Reviewed Original ResearchCreation and Validation of an Automated Registry for Outpatient Parenteral Antibiotics
Canterino J, Malinis M, Liu J, Kashyap N, Brandt C, Justice A. Creation and Validation of an Automated Registry for Outpatient Parenteral Antibiotics. Open Forum Infectious Diseases 2024, 11: ofae004. PMID: 38412514, PMCID: PMC10866572, DOI: 10.1093/ofid/ofae004.Peer-Reviewed Original ResearchElectronic medical recordsOutpatient parenteral antibiotic therapyOutpatient parenteral antibiotic therapy programsMedical recordsObjective dataHospital length of stayOPAT episodesLength of stayDischarge dispositionUnique patientsRegistryParenteral antibiotic therapyInsurance payorOutpatient parenteral antibioticsDeath rateHospital lengthHospital daysAntibiotic therapyParenteral antibioticsInfection syndromeHospitalProgramAntibiotic name
2023
Implementation and evaluation of an electronic health record-integrated app for postpartum monitoring of hypertensive disorders of pregnancy using patient-contributed data collection
Dullabh P, Heaney-Huls K, Chiao A, Callaham M, Desai P, Gauthreaux N, Kashyap N, Lobach D, Boxwala A. Implementation and evaluation of an electronic health record-integrated app for postpartum monitoring of hypertensive disorders of pregnancy using patient-contributed data collection. JAMIA Open 2023, 6: ooad098. PMID: 38028731, PMCID: PMC10646567, DOI: 10.1093/jamiaopen/ooad098.Peer-Reviewed Original ResearchElectronic health recordsHypertensive disordersRemote patient monitoring programPostpartum monitoringLocal clinical championsClinical championsPatient involvementIntegration standardsKey observationPilot interventionEHR developersClinician usersHealth recordsClinical workflowRemote monitoringDisordersPregnancyAppsSmartphone applicationInterventionData collectionPatientsDevelopersUsersUsability33 THE IMPLEMENTATION OF AN EMR-BASED AUTOMATED SYSTEM FOR IDENTIFICATION OF PATIENTS SUSPICIOUS FOR LYNCH SYNDROME HAS A DISPROPORTIONALLY POSITIVE IMPACT IN THE IDENTIFICATION OF DISADVANTAGED PATIENTS
Soleymanjahi S, Singh V, Liu J, Brown Q, Brierley K, Healy C, Xicola R, Kashyap N, Llor X. 33 THE IMPLEMENTATION OF AN EMR-BASED AUTOMATED SYSTEM FOR IDENTIFICATION OF PATIENTS SUSPICIOUS FOR LYNCH SYNDROME HAS A DISPROPORTIONALLY POSITIVE IMPACT IN THE IDENTIFICATION OF DISADVANTAGED PATIENTS. Gastroenterology 2023, 164: s-11. DOI: 10.1016/s0016-5085(23)00980-0.Peer-Reviewed Original ResearchExperiences with Cyclical User-Centered Design for Patient and Clinician Facing Medication Reconciliation mHealth Applications.
Polomoff C, Jeffery S, Agresta T, Bektashev S, Tran R, Frazier W, Demurjian S, O'Dell J, Sinha S, Kashyap N. Experiences with Cyclical User-Centered Design for Patient and Clinician Facing Medication Reconciliation mHealth Applications. AMIA Annual Symposium Proceedings 2023, 2022: 874-883. PMID: 37128468, PMCID: PMC10148378.Peer-Reviewed Original ResearchImplementing real-time prescription benefit tools: Early experiences from 5 academic medical centers
Luo J, Wong R, Mehta T, Schwartz J, Epstein J, Smith E, Kashyap N, Woreta F, Feterik K, Fliotsos M, Crotty B. Implementing real-time prescription benefit tools: Early experiences from 5 academic medical centers. Healthcare 2023, 11: 100689. PMID: 36989915, PMCID: PMC10880821, DOI: 10.1016/j.hjdsi.2023.100689.Peer-Reviewed Original ResearchColchicine and high-intensity rosuvastatin in the treatment of non-critically ill patients hospitalised with COVID-19: a randomised clinical trial
Shah T, McCarthy M, Nasir I, Archer H, Ragheb E, Kluger J, Kashyap N, Paredes C, Patel P, Lu J, Kandel P, Song C, Khan M, Huang H, Haq F, Ahmad R, Howes C, Cambi B, Lancaster G, Cleman M, Dela Cruz C, Parise H, Lansky A. Colchicine and high-intensity rosuvastatin in the treatment of non-critically ill patients hospitalised with COVID-19: a randomised clinical trial. BMJ Open 2023, 13: e067910. PMID: 36828654, PMCID: PMC9971831, DOI: 10.1136/bmjopen-2022-067910.Peer-Reviewed Original ResearchConceptsStandard of careHigh-intensity rosuvastatinElectronic medical recordsCOVID-19 diseaseMedical recordsPrimary endpointThromboembolic eventsYale New Haven Health SystemSevere COVID-19 diseaseCOVID-19Prespecified primary endpointVenous thromboembolic eventsRisk of progressionCombination of colchicineSafety monitoring boardCare armHispanics/LatinosTherapeutic anticoagulationIndex hospitalisationIll patientsMedian ageFuture trialsEffect of colchicineClinical trialsMonitoring boardImplementation and evaluation of an electronic health record-integrated app for postpartum monitoring of hypertensive disorders of pregnancy using patient-contributed data collection
Dullabh P, Heaney-Huls KK, Chiao AB, Callaham MG, Desai P, Gauthreaux NA, Kashyap N, Lobach DF, Boxwala A. Implementation and evaluation of an electronic health record-integrated app for postpartum monitoring of hypertensive disorders of pregnancy using patient-contributed data collection, JAMIA Open, Volume 6, Issue 4, December 2023, ooad098, https://doi.org/10.1093/jamiaopen/ooad098Peer-Reviewed Original Research In Press
2022
Where Do Real-Time Prescription Benefit Tools Fit in the Landscape of High US Prescription Medication Costs? A Narrative Review
Wong R, Mehta T, Very B, Luo J, Feterik K, Crotty B, Epstein J, Fliotsos M, Kashyap N, Smith E, Woreta F, Schwartz J. Where Do Real-Time Prescription Benefit Tools Fit in the Landscape of High US Prescription Medication Costs? A Narrative Review. Journal Of General Internal Medicine 2022, 38: 1038-1045. PMID: 36441366, PMCID: PMC10039141, DOI: 10.1007/s11606-022-07945-z.Peer-Reviewed Original ResearchConceptsMedication costsElectronic clinical decision support toolPocket medication costsPrescription medication costsPoor patient adherenceWorse clinical outcomesClinical decision support toolUS healthcare costsPocket cost informationElectronic health recordsPharmacologic treatmentClinical outcomesPatient adherencePrescription medicationsHealthcare costsPatientsNarrative reviewHealth systemMedicaid ServicesLimited evidenceHealth recordsHealthcare systemFinancial burdenAdherenceMultiple factorsIntegrating a Patient Engagement App into an Electronic Health Record-Enabled Workflow Using Interoperability Standards
Lobach D, Boxwala A, Kashyap N, Heaney-Huls K, Chiao A, Rafter T, Lomotan E, Harrison M, Dymek C, Swiger J, Dullabh P. Integrating a Patient Engagement App into an Electronic Health Record-Enabled Workflow Using Interoperability Standards. Applied Clinical Informatics 2022, 13: 1163-1171. PMID: 36516969, PMCID: PMC9750793, DOI: 10.1055/s-0042-1758736.Peer-Reviewed Original ResearchConceptsFast Healthcare Interoperability ResourcesApplication programming interfaceFHIR standardElectronic health recordsInteroperability standardsApplication development teamClinical workflowCOVID-19 trackerHealth recordsStandards-based approachIntegration of appsFHIR resourcesProgramming interfaceMobile health applicationsMobile applicationsWorkflow integrationDevelopment teamsClinician workflowPartial implementationWorkflowHealth applicationsAppsClinical systemsSuch integrationText messagesThe first 20 months of the COVID-19 pandemic: Mortality, intubation and ICU rates among 104,590 patients hospitalized at 21 United States health systems
Fiore M, Smith S, Adsit R, Bolt D, Conner K, Bernstein S, Eng O, Lazuk D, Gonzalez A, Jorenby D, D’Angelo H, Kirsch J, Williams B, Nolan M, Hayes-Birchler T, Kent S, Kim H, Piasecki T, Slutske W, Lubanski S, Yu M, Suk Y, Cai Y, Kashyap N, Mathew J, McMahan G, Rolland B, Tindle H, Warren G, An L, Boyd A, Brunzell D, Carrillo V, Chen L, Davis J, Dilip D, Ellerbeck E, Iturrate E, Jose T, Khanna N, King A, Klass E, Newman M, Shoenbill K, Tong E, Tsoh J, Wilson K, Theobald W, Baker T. The first 20 months of the COVID-19 pandemic: Mortality, intubation and ICU rates among 104,590 patients hospitalized at 21 United States health systems. PLOS ONE 2022, 17: e0274571. PMID: 36170336, PMCID: PMC9518859, DOI: 10.1371/journal.pone.0274571.Peer-Reviewed Original ResearchConceptsCOVID-19 patientsICU admission rateUnited States health systemState health systemAdmission ratesPositive COVID-19 PCR testCOVID-19 PCR testHospitalized COVID-19 patientsHealth systemHealth system contactElectronic health record dataICD-10 diagnosisAge 18 yearsCOVID-19 hospitalizationRisk-standardized mortalityHealth record dataHigh mortality rateCOVID-19 pandemicICU admissionHospitalized participantsEndotracheal intubationIntubation rateMean agePatient groupPatient outcomesSmoking Status, Nicotine Medication, Vaccination, and COVID-19 Hospital Outcomes: Findings from the COVID EHR Cohort at the University of Wisconsin (CEC-UW) Study
Piasecki T, Smith S, Baker T, Slutske W, Adsit R, Bolt D, Conner K, Bernstein S, Eng O, Lazuk D, Gonzalez A, Jorenby D, D’Angelo H, Kirsch J, Williams B, Nolan M, Hayes-Birchler T, Kent S, Kim H, Lubanski S, Yu M, Suk Y, Cai Y, Kashyap N, Mathew J, McMahan G, Rolland B, Tindle H, Warren G, An L, Boyd A, Brunzell D, Carrillo V, Chen L, Davis J, Deshmukh V, Dilip D, Ellerbeck E, Goldstein A, Iturrate E, Jose T, Khanna N, King A, Klass E, Mermelstein R, Tong E, Tsoh J, Wilson K, Theobald W, Fiore M. Smoking Status, Nicotine Medication, Vaccination, and COVID-19 Hospital Outcomes: Findings from the COVID EHR Cohort at the University of Wisconsin (CEC-UW) Study. Nicotine & Tobacco Research 2022, 25: 1184-1193. PMID: 36069915, PMCID: PMC9494410, DOI: 10.1093/ntr/ntac201.Peer-Reviewed Original ResearchConceptsNicotine replacement therapySARS-CoV-2 vaccinationCOVID-19 patientsCurrent smokersFormer smokersSmoking statusCOVID-19 outcomesICU admissionNRT prescriptionHospital outcomesVaccination statusReplacement therapySevere COVID-19 disease outcomesCOVID-19 clinical outcomesCOVID-19 disease outcomesBetter hospital outcomesOdds of deathBody mass indexElectronic health record dataLarge cohort studyCOVID-19 hospitalizationHealth record dataPotential beneficial effectsU.S. health systemEHR cohort
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