2011
Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus
Mishra NK, Ahmed N, Davalos A, Iversen HK, Melo T, Soinne L, Wahlgren N, Lees KR. Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus. Neurology 2011, 77: 1866-1872. PMID: 22094479, DOI: 10.1212/wnl.0b013e318238ee42.Peer-Reviewed Original ResearchConceptsNIH Stroke Scale scoreBaseline NIH Stroke Scale scoreConcomitant diabetes mellitusPrior strokeIschemic stroke patientsDiabetes mellitusThrombolytic therapyStroke patientsOdds ratioScale scoreAcute ischemic stroke patientsInfluence of DMOutcomes of patientsStroke Scale scoreRankin Scale scoreConfidence intervalsDistribution of mRSAlteplase treatmentProportional odds logistic regressionMRS outcomesThrombolysis outcomesPatientsHaenszel testEuropean approvalCochran-Mantel
2010
Thrombolysis in very elderly people: controlled comparison of SITS International Stroke Thrombolysis Registry and Virtual International Stroke Trials Archive
Mishra NK, Ahmed N, Andersen G, Egido JA, Lindsberg PJ, Ringleb PA, Wahlgren NG, Lees KR. Thrombolysis in very elderly people: controlled comparison of SITS International Stroke Thrombolysis Registry and Virtual International Stroke Trials Archive. The BMJ 2010, 341: c6046. PMID: 21098614, PMCID: PMC2990864, DOI: 10.1136/bmj.c6046.Peer-Reviewed Original ResearchConceptsVirtual International Stroke Trials ArchiveNon-randomised patientsAcute ischemic strokeProportional odds logistic regression analysisComparison of outcomesLogistic regression analysisNeuroprotection trialsSITS-ISTREffect of ageIschemic strokeHaenszel testCochran-MantelThrombolysisPatientsRegression analysisInfluence of Age on Outcome From Thrombolysis in Acute Stroke
Mishra NK, Diener HC, Lyden PD, Bluhmki E, Lees KR. Influence of Age on Outcome From Thrombolysis in Acute Stroke. Stroke 2010, 41: 2840-2848. PMID: 21030710, DOI: 10.1161/strokeaha.110.586206.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeHealth scale scoresControl subjectsIschemic strokeInfluence of ageScale scoreBaseline National InstitutesRankin Scale scoreNational InstituteLimited trial dataNeuroprotection trialsRankin scoreThrombolysis treatmentAcute strokeYounger patientsAge decilesPoor outcomeBaseline severityImproved outcomesPatientsHaenszel testTrial dataCochran-MantelThrombolysisLogistic regressionComparison of Outcomes Following Thrombolytic Therapy Among Patients With Prior Stroke and Diabetes in the Virtual International Stroke Trials Archive (VISTA)
Mishra NK, Davis SM, Kaste M, Lees KR, . Comparison of Outcomes Following Thrombolytic Therapy Among Patients With Prior Stroke and Diabetes in the Virtual International Stroke Trials Archive (VISTA). Diabetes Care 2010, 33: 2531-2537. PMID: 20843977, PMCID: PMC2992183, DOI: 10.2337/dc10-1125.Peer-Reviewed Original ResearchConceptsVirtual International Stroke Trials ArchivePrior strokeUse of alteplaseBaseline National InstitutesHealth Stroke ScaleProportional odds logistic regression analysisInfluence of diabetesInteraction of diabetesComparison of outcomesLogistic regression analysisConcomitant diabetesEligible patientsNeurological outcomeStroke ScaleIschemic strokeThrombolytic treatmentThrombolytic therapyThrombolysed patientsFunctional outcomeControl subjectsOutcome measuresPatientsDiabetesHaenszel testCochran-Mantel