2020
Autonomic Dysfunction in Women with Androgen Excess PCOS
Stone T, Leone C, Ayers T, Stachenfeld N. Autonomic Dysfunction in Women with Androgen Excess PCOS. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.01846.Peer-Reviewed Original ResearchLower body negative pressurePolycystic ovary syndromeForearm vascular resistanceGnRH-antBlood pressureBaroreflex sensitivityEstrogen suppressionBRS slopeHormone suppressionAutonomic functionElevated blood pressureReproductive-age womenBody negative pressureTestosterone-induced changesAutonomic dysfunctionMild hypertensionVascular resistanceObese womenOvary syndromeGnRH antagonistAge womenBP regulationCardiovascular diseaseReproductive endocrinopathyBiochemical manifestations
2011
Testosterone lowers microvascular ET‐B receptor responsiveness in women with PCOS
Wenner M, Taylor H, Stachenfeld N. Testosterone lowers microvascular ET‐B receptor responsiveness in women with PCOS. The FASEB Journal 2011, 25: lb559-lb559. DOI: 10.1096/fasebj.25.1_supplement.lb559.Peer-Reviewed Original ResearchPolycystic ovary syndromeHeat-induced vasodilationT administrationCutaneous vascular conductance responsesET-1 plasma concentrationsET-B receptor antagonistImpaired microvascular functionET-B receptorsVascular conductance responsesEndogenous sex hormonesLaser Doppler flowmetryPCOS showOvary syndromeGnRH antagonistMicrovascular functionVascular dysfunctionReceptor antagonistReceptor responsivenessMicrodialysis infusionSex hormonesPlasma concentrationsDoppler flowmetryReceptor sensitivityT exposureTestosterone exposureProgesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance
Wenner MM, Taylor HS, Stachenfeld NS. Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance. The Journal Of Physiology 2011, 589: 975-986. PMID: 21173076, PMCID: PMC3060374, DOI: 10.1113/jphysiol.2010.194563.Peer-Reviewed Original ResearchConceptsLow orthostatic toleranceHigh orthostatic toleranceOrthostatic toleranceAdrenergic responseAdrenergic responsivenessNitric oxide synthase inhibitor NG-monomethylEndogenous sex hormone productionSynthase inhibitor NG-monomethylSkin blood flow responseBlood flow responseInhibitor NG-monomethylSex hormone productionFemale sex hormonesLower body negative pressure testSkin blood flowGnRH antagonistProgesterone administrationOrthostatic intoleranceNG-monomethylPeripheral αMicrodialysis infusionSex hormonesCyclooxygenase pathwayHT womenAdrenergic control
2010
Peripheral microvascular responses to norepinephrine in women with orthostatic intolerance
Wenner M, Taylor H, Stachenfeld N. Peripheral microvascular responses to norepinephrine in women with orthostatic intolerance. The FASEB Journal 2010, 24: 991.17-991.17. DOI: 10.1096/fasebj.24.1_supplement.991.17.Peer-Reviewed Original ResearchCumulative stress indexVasoconstrictor responsesAdrenergic responseMaximal lower body negative pressureLower body negative pressurePeripheral microvascular responseEffects of estradiolBody negative pressureFemale sex hormonesSkin blood flowEndogenous E2GnRH antagonistNE infusionDaily administrationMicrovascular responsesCutaneous microvasculatureOrthostatic intoleranceOrthostatic toleranceSex hormonesBlood flowSkin microvasculatureAdrenergic stimulationDay 4Hormone treatmentDay 13
2007
Exogenous oestradiol and progesterone administration does not cause oedema in healthy young women
Stachenfeld NS, Taylor HS. Exogenous oestradiol and progesterone administration does not cause oedema in healthy young women. Clinical Endocrinology 2007, 66: 410-418. PMID: 17302877, DOI: 10.1111/j.1365-2265.2007.02748.x.Peer-Reviewed Original ResearchConceptsExtracellular fluid volumeTranscapillary albumin escape rateGonadotropin-releasing hormone antagonistPmol/Plasma renin activitySerum aldosterone concentrationHealthy young womenAlbumin escape rateRenin activityAldosterone concentrationGnRH antagonistHealthy womenProgesterone administrationExogenous oestradiolIntravascular volumeHormone antagonistProgesterone increaseDay 2Day 5Hormone treatmentOestradiolDay 13Extravascular componentOncotic pressureYoung women
2005
Progesterone increases plasma volume independent of estradiol
Stachenfeld NS, Taylor HS. Progesterone increases plasma volume independent of estradiol. Journal Of Applied Physiology 2005, 98: 1991-1997. PMID: 15718411, DOI: 10.1152/japplphysiol.00031.2005.Peer-Reviewed Original ResearchConceptsTranscapillary escape ratePlasma concentrationsPlasma volumeGnRH antagonistECF volumeAdequate plasma volumeAldosterone system stimulationPlasma renin activityGonadotropin-releasing hormoneExtracellular fluid volumeRenin activitySerum aldosteroneAng IIBlood pressureEstrogen administrationSystem stimulationDay 2Day 5Pg/Day 13Fluid regulationPV expansionFluid volumeIndependent effectsProgesterone
2004
Responses to a Saline Load in Gonadotropin-Releasing Hormone Antagonist-Pretreated Premenopausal Women Receiving Progesterone or Estradiol-Progesterone Therapy
Stachenfeld NS, Keefe DL, Taylor HS. Responses to a Saline Load in Gonadotropin-Releasing Hormone Antagonist-Pretreated Premenopausal Women Receiving Progesterone or Estradiol-Progesterone Therapy. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 386-394. PMID: 15486051, DOI: 10.1210/jc.2004-0941.Peer-Reviewed Original ResearchConceptsSodium regulationOvarian hyperstimulation syndromeEffects of estradiolMin of restImportant clinical implicationsHyperstimulation syndromeSodium excretionGnRH antagonistRenal diseaseSodium loadIsotonic salineClinical implicationsSyndromeReproductive syndromeSubjectsPreeclampsiaGnRHGroupEstradiolProgesteroneAntagonistExcretionDiseaseAdministrationSaline
2003
Effects of estrogen and progesterone administration on extracellular fluid
Stachenfeld NS, Taylor HS. Effects of estrogen and progesterone administration on extracellular fluid. Journal Of Applied Physiology 2003, 96: 1011-1018. PMID: 14660504, DOI: 10.1152/japplphysiol.01032.2003.Peer-Reviewed Original ResearchConceptsGnRH antagonist administrationExtracellular fluid volumeGnRH antagonistEffects of estrogenAntagonist administrationPlasma volumeTranscapillary escape rateGonadotropin-releasing hormoneExtracellular fluidHealthy womenProgesterone administrationECFV expansionGanirelix acetateEndogenous estrogensStrong negative predictorDay 2Day 5Pg/AntagonistEstrogenDay 12Plasma compartmentCapillary endotheliumAdministrationProgesterone