2024
Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest
Annoni F, Su F, Peluso L, Lisi I, Caruso E, Pischiutta F, Gouvea Bogossian E, Garcia B, Njimi H, Vincent J, Gaspard N, Ferlini L, Creteur J, Zanier E, Taccone F. Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest. Critical Care 2024, 28: 314. PMID: 39304944, PMCID: PMC11414246, DOI: 10.1186/s13054-024-05106-8.Peer-Reviewed Original ResearchConceptsReturn of spontaneous circulationCardiac arrestTreated animalsClinically relevant swine modelExperimental cardiac arrestResuscitated CACompared to controlsBrain injurySpontaneous circulationBalanced crystalloidsCirculating markersInjury biomarkersCerebral injuryCerebral glucose uptakePlasma biomarkersInfusionBlood sodium concentrationCardiopulmonary resuscitationSwine modelCardiovascular monitoringExperimental modelSodium concentrationAdult swineInjuryResuscitationEEG for good outcome prediction after cardiac arrest: A multicentre cohort study
Turella S, Dankiewicz J, Ben-Hamouda N, Nilsen K, Düring J, Endisch C, Engstrøm M, Flügel D, Gaspard N, Grejs A, Haenggi M, Haffey S, Imbach L, Johnsen B, Kemlink D, Leithner C, Legriel S, Lindehammar H, Mazzon G, Nielsen N, Peyre A, Stanford B, Roman-Pognuz E, Rossetti A, Schrag C, Valeriánová A, Wendel-Garcia P, Zubler F, Cronberg T, Westhall E, investigators T. EEG for good outcome prediction after cardiac arrest: A multicentre cohort study. Resuscitation 2024, 202: 110319. PMID: 39029579, DOI: 10.1016/j.resuscitation.2024.110319.Peer-Reviewed Original ResearchConceptsMalignant EEG patternsEEG reactivityReactive EEGsCardiac arrestComatose patientsEEG patternsOut-of-hospital cardiac arrest trialModified Rankin Scale scoreMulticentre cohort studyRankin Scale scoreLong-term outcomesOut-of-hospitalCardiac arrest trialsSpecificity of EEGEEG assessmentHospital stayGood outcomeMultimodal prognosticationPrognostic performanceNon-highlyPrognostic abilityCohort studyMalignant patternArrest trialsBurst suppressionQuantitative Characterization of Rhythmic and Periodic EEG Patterns in Patients in a Coma After Cardiac Arrest and Association With Outcome
van Putten M, Ruijter B, Horn J, van Rootselaar A, Tromp S, van Kranen-Mastenbroek V, Gaspard N, Hofmeijer J, Investigators F. Quantitative Characterization of Rhythmic and Periodic EEG Patterns in Patients in a Coma After Cardiac Arrest and Association With Outcome. Neurology 2024, 103: e209608. PMID: 38991197, DOI: 10.1212/wnl.0000000000209608.Peer-Reviewed Original Research
2021
Clinical presentation of new onset refractory status epilepticus in children (the pSERG cohort)
Sculier C, Aguilar C, Gaspard N, Gaínza‐Lein M, Fernández I, Amengual‐Gual M, Anderson A, Arya R, Burrows B, Brenton J, Carpenter J, Chapman K, Clark J, Gaillard W, Glauser T, Goldstein J, Goodkin H, Gorman M, Lai Y, McDonough T, Mikati M, Nayak A, Peariso K, Riviello J, Rusie A, Sperberg K, Stredny C, Tasker R, Tchapyjnikov D, Vasquez A, Wainwright M, Wilfong A, Williams K, Loddenkemper T, pSERG. Clinical presentation of new onset refractory status epilepticus in children (the pSERG cohort). Epilepsia 2021, 62: 1629-1642. PMID: 34091885, PMCID: PMC8362203, DOI: 10.1111/epi.16950.Peer-Reviewed Original ResearchConceptsOnset refractory status epilepticusRefractory status epilepticusRefractory SEFebrile SEStatus epilepticusUnknown etiologyBaseline neurological functionSE onsetMedian ageProlonged SESE episodesClinical presentationPediatric patientsClinical characteristicsFever onsetClinical profileSubgroup analysisNeurological functionEpilepsy syndromesPatientsFeverDiagnostic criteriaEpilepticusEtiologyBaseline function