Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest
Annoni F, Su F, Peluso L, Lisi I, Caruso E, Pischiutta F, Gouvea Bogossian E, Garcia B, Njimi H, Vincent J, Gaspard N, Ferlini L, Creteur J, Zanier E, Taccone F. Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest. Critical Care 2024, 28: 314. PMID: 39304944, PMCID: PMC11414246, DOI: 10.1186/s13054-024-05106-8.Peer-Reviewed Original ResearchMeSH Keywords3-Hydroxybutyric AcidAnimalsBiomarkersBrain InjuriesCardiopulmonary ResuscitationDisease Models, AnimalHeart ArrestMaleSodium OxybateSwineConceptsReturn of spontaneous circulationCardiac arrestTreated animalsClinically relevant swine modelExperimental cardiac arrestResuscitated CACompared to controlsBrain injurySpontaneous circulationBalanced crystalloidsCirculating markersInjury biomarkersCerebral injuryCerebral glucose uptakePlasma biomarkersInfusionBlood sodium concentrationCardiopulmonary resuscitationSwine modelCardiovascular monitoringExperimental modelSodium concentrationAdult swineInjuryResuscitationEEG for good outcome prediction after cardiac arrest: A multicentre cohort study
Turella S, Dankiewicz J, Ben-Hamouda N, Nilsen K, Düring J, Endisch C, Engstrøm M, Flügel D, Gaspard N, Grejs A, Haenggi M, Haffey S, Imbach L, Johnsen B, Kemlink D, Leithner C, Legriel S, Lindehammar H, Mazzon G, Nielsen N, Peyre A, Stanford B, Roman-Pognuz E, Rossetti A, Schrag C, Valeriánová A, Wendel-Garcia P, Zubler F, Cronberg T, Westhall E, investigators T. EEG for good outcome prediction after cardiac arrest: A multicentre cohort study. Resuscitation 2024, 202: 110319. PMID: 39029579, DOI: 10.1016/j.resuscitation.2024.110319.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiopulmonary ResuscitationComaElectroencephalographyFemaleHumansHypothermia, InducedMaleMiddle AgedOut-of-Hospital Cardiac ArrestPredictive Value of TestsPrognosisProspective StudiesConceptsMalignant EEG patternsEEG reactivityReactive EEGsCardiac arrestComatose patientsEEG patternsOut-of-hospital cardiac arrest trialModified Rankin Scale scoreMulticentre cohort studyRankin Scale scoreLong-term outcomesOut-of-hospitalCardiac arrest trialsSpecificity of EEGEEG assessmentHospital stayGood outcomeMultimodal prognosticationPrognostic performanceNon-highlyPrognostic abilityCohort studyMalignant patternArrest trialsBurst suppression