2024
Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest
Annoni F, Su F, Peluso L, Lisi I, Caruso E, Pischiutta F, Gouvea Bogossian E, Garcia B, Njimi H, Vincent J, Gaspard N, Ferlini L, Creteur J, Zanier E, Taccone F. Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest. Critical Care 2024, 28: 314. PMID: 39304944, PMCID: PMC11414246, DOI: 10.1186/s13054-024-05106-8.Peer-Reviewed Original ResearchConceptsReturn of spontaneous circulationCardiac arrestTreated animalsClinically relevant swine modelExperimental cardiac arrestResuscitated CACompared to controlsBrain injurySpontaneous circulationBalanced crystalloidsCirculating markersInjury biomarkersCerebral injuryCerebral glucose uptakePlasma biomarkersInfusionBlood sodium concentrationCardiopulmonary resuscitationSwine modelCardiovascular monitoringExperimental modelSodium concentrationAdult swineInjuryResuscitationCombined depth and scalp electroencephalographic monitoring in acute brain injury: Yield and prognostic value
Yuan F, Damien C, Schuind S, Salvagno M, Taccone F, Legros B, Gaspard N. Combined depth and scalp electroencephalographic monitoring in acute brain injury: Yield and prognostic value. European Journal Of Neurology 2024, 31: e16208. PMID: 38270448, PMCID: PMC11235592, DOI: 10.1111/ene.16208.Peer-Reviewed Original ResearchIctal-interictal continuumAcute brain injuryAcute brain injury patientsIctal-interictal continuum patternsDepth electroencephalographyRate of poor outcomeSporadic epileptiform dischargesElectrophysiological activityIctal rhythmic dischargesSpike-and-waveBrain injuryAbnormal electrophysiological activityElectrographic seizuresEpileptiform dischargesPoor outcomeRhythmic dischargesPatientsElectroencephalographic monitoringConcomitant seizuresScalp EEGPeriodic dischargesSeizuresNeuromonitoringABI patientsInjury
2023
Status epilepticus in the ICU
Rossetti A, Claassen J, Gaspard N. Status epilepticus in the ICU. Intensive Care Medicine 2023, 50: 1-16. PMID: 38117319, DOI: 10.1007/s00134-023-07263-w.Peer-Reviewed Original ResearchSuper-refractory status epilepticusIntensive care unitStatus epilepticusAntiseizure medicationsUnderlying causeContinuous video electroencephalographyAcute brain injuryConvulsive status epilepticusNon-pharmacologic approachesNonconvulsive status epilepticusShort-term mortalityCommon medical emergencyAutoimmune encephalitisMedical comorbiditiesInitial managementSignificant morbidityCare unitCardiac arrestResponsive casesVideo electroencephalographyContinuous infusionBrain injuryRapid administrationSevere casesMedical emergency
2015
The Time Course and Prognostic Values of Electroencephalographic Patterns after Anoxic Brain Injury (P7.005)
Sivaraju A, Gilmore E, Moeller J, Greer D, Hirsch L, Gaspard N. The Time Course and Prognostic Values of Electroencephalographic Patterns after Anoxic Brain Injury (P7.005). Neurology 2015, 84 DOI: 10.1212/wnl.84.14_supplement.p7.005.Peer-Reviewed Original Research