2025
Spatial transcriptomics reveals human cortical layer and area specification
Qian X, Coleman K, Jiang S, Kriz A, Marciano J, Luo C, Cai C, Manam M, Caglayan E, Lai A, Exposito-Alonso D, Otani A, Ghosh U, Shao D, Andersen R, Neil J, Johnson R, LeFevre A, Hecht J, Micali N, Sestan N, Rakic P, Miller M, Sun L, Stringer C, Li M, Walsh C. Spatial transcriptomics reveals human cortical layer and area specification. Nature 2025, 1-11. PMID: 40369074, DOI: 10.1038/s41586-025-09010-1.Peer-Reviewed Original ResearchNeuronal subtypesMid-gestationHuman fetal cortexExcitatory neuron subtypesCortical layersLayer 4 neuronsCortical areasHuman cortical developmentGestational weeksFetal cortexSingle-nucleus RNA sequencingCortical developmentCerebral cortexSingle-cell transcriptomic studiesHuman cerebral cortexDevelopmental time pointsLaminar distributionAreal specificationCortical arealizationTime pointsSubtypesCortexVisual cortexSingle-cell resolutionCytoarchitectural development
2020
Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates
Micali N, Kim SK, Diaz-Bustamante M, Stein-O’Brien G, Seo S, Shin JH, Rash BG, Ma S, Wang Y, Olivares NA, Arellano JI, Maynard KR, Fertig EJ, Cross AJ, Bürli RW, Brandon NJ, Weinberger DR, Chenoweth JG, Hoeppner DJ, Sestan N, Rakic P, Colantuoni C, McKay RD. Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates. Cell Reports 2020, 31: 107599. PMID: 32375049, PMCID: PMC7357345, DOI: 10.1016/j.celrep.2020.107599.Peer-Reviewed Original ResearchConceptsNeural stem cellsNeuronal fateProliferative neural stem cellsStem cellsPluripotent linesTelencephalic fateRNA sequencingLineage tracingHuman neural stem cellsGlutamatergic excitatory neuronsMonkey brain sectionsNeuronal trajectoriesCell imagingCortical excitatoryCerebral cortexFateExcitatory neuronsBrain sectionsHuman telencephalonNeuropsychiatric disordersAcute transitionPluripotencyCellsCortexSequencing
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